1. Brain injury patterns in hypoglycemia in neonatal encephalopathy
- Author
-
Vann Chau, Steven P. Miller, Alan Hill, Elke H. Roland, Kenneth J. Poskitt, Emily W.Y. Tam, and Darren S. T. Wong
- Subjects
Blood Glucose ,Male ,Resuscitation ,Midline Thalamic Nuclei ,Brain Edema ,Neuroimaging ,Hypoglycemia ,Pulvinar ,Pediatrics ,Basal Ganglia ,Fetal Distress ,Infant, Newborn, Diseases ,White matter ,Cohort Studies ,Predictive Value of Tests ,medicine.artery ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Prospective Studies ,Prospective cohort study ,Neonatal encephalopathy ,business.industry ,Neonatal hypoglycemia ,Infant, Newborn ,nutritional and metabolic diseases ,Brain ,Umbilical artery ,medicine.disease ,Image Enhancement ,Magnetic Resonance Imaging ,medicine.anatomical_structure ,Diffusion Magnetic Resonance Imaging ,Predictive value of tests ,Anesthesia ,Hypoxia-Ischemia, Brain ,Apgar Score ,Apgar score ,Female ,Neurology (clinical) ,business ,Acidosis - Abstract
BACKGROUND AND PURPOSE: Low glucose values are often seen in term infants with NE, including HIE, yet the contribution of hypoglycemia to the pattern of neurologic injury remains unclear. We hypothesized that MR features of neonatal hypoglycemia could be detected, superimposed on the predominant HIE injury pattern. MATERIALS AND METHODS: Term neonates (n = 179) with NE were prospectively imaged with day-3 MR studies and had glucose data available for review. The predominant imaging pattern of HIE was recorded as watershed, basal ganglia, total, focal-multifocal, or no injury. Radiologic hypoglycemia was diagnosed on the basis of selective edema in the posterior white matter, pulvinar, and anterior medial thalamic nuclei. Clinical charts were reviewed for evidence of NE, HIE, and hypoglycemia (
- Published
- 2013