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The enzymatic synthetic activity of peripheral blood lymphocytes was changed in the newborns whose mothers suffered from habitual miscarriages and were administered courses of metabolic therapy as part of combined pathogenetic treatment (basis therapy). Metabolic therapy brought about positive shifts which manifested by a reliable activation of succinate dehydrogenase and alpha-glycerophosphate dehydrogenase, this, in its turn, creating favorable conditions for the functioning of the mother-placenta-fetus metabolic system and being conductive to a better adaptation of the newborns in the early neonatal period. Metabolic therapy brought about a twofold reduction of the incidence of fetal hypoxia and hypotrophy.

Use of cardiotocography as the fetal status index in complex with other criteria and medical algorithms in pregnant women during the IIIrd trimester helped better select the term and method of delivery for each patient with threatened fetal distress. The choice of the optimal individual method of delivery for each pregnant woman decreased the risk of the process of labor and reduced by 2.2 times the number of children born in a state of complicated hypoxia.

The protective effect of the narcoanalgetics, viadril (hydroxydione sodium succinate) and administered intraperitoneally in doses of 5 and 20 mg/kg was studied in the experiment on 146 pregnant noninbred white rats with simulated hemic hypoxia in the late pregnancy (the 19th day). The aforementioned rats were studied for the composition of the peripheral blood, their weight gain oxidative isoenzymes (LDH), pH and pO2 in the blood. Wilson's technique was used for the assessment of the fetal status. The offspring was studied with regard to the weight increment, the rate of postnatal mortality, behavioral reactions, etc. It was stated that viadril strengthened the resistance of pregnant animals to hypoxia and contributed to the alleviation of late sequela of posthypoxic changes in the fetus and newborn.

At most, 40 pregnant females at a high risk for fetal perinatal pathology underwent clinical investigation, ultrasonic scanning of the placenta, recording of the fetal electro- and phonocardiography, the evaluation of the placental levels of lactogen and estradiol and thermoresistant alkaline phosphatase changes of the values considered who were then treated with hyperbaric oxygenation (HBO) under the control of dynamic placental scintigraphy. Based on the placentographic findings, the authors distinguished from the whole of the risk-group the patients whose pattern of uteroplacental blood flow response to the treatment was beneficial and therefore the HBO treatment for fetoplacental insufficiency was advisable.

A package of measures to ensure the antenatal protection of the fetus was proposed on the basis of comprehensive fetal investigations performed in 200 pregnant females with congenital heart disease.

A total of 65 women in labor complicated with uterine inertia were investigated for tissue pO2 and cardiac performance of fetuses under the effect of oxytocin. The authors stated that the aggravation of fetal status in drug-induced labors resulted from poorer tissue oxygenation caused by the activation of uterine contractility. In this line, hypoxic changes of the fetus were more pronounced in pregnancies complicated by nephropathy or prolonged pregnancy. Accurate monitoring of the fetal status and the character of induced labor course was found to be mandatory. Before oxytocin induction the fetus should be protected with diazepam.