1. PRENATAL ALCOHOL EXPOSURE AND THE NEUROAPOPTOSIS WITH LONG-TERM EFFECT IN VISUAL CORTEX OF MICE.
- Author
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Qiying Jiang, Yanqiu Hu, Ping Wu, Xiangshu Cheng, Mingshan Li, Dongming Yu, and Jinbo Deng
- Subjects
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VISUAL cortex , *ALCOHOL , *MICE , *PRENATAL care , *IMMUNOCYTOCHEMISTRY , *NEURONS , *PREGNANCY , *POSTNATAL care , *NEUROBEHAVIORAL disorders - Abstract
Aims: The prenatal ethanol exposure induced neuroapoptosis and neuron loss in visual cortex would be investigated in mice at P0, P7 and P14. Methods: Intubating pregnant mice ethanol daily began on E5 and continued through the pup's birth. The neuroapoptosis in visual cortex was visualized by the caspase 3 immunocytochemistry, and the neuron loss was observed with Nissl method as well. Results: With prenatal ethanol exposure, the dose-dependent neuroapoptosis and neuron loss in visual cortex could be found at P0 and even at P7 and P14 as well. Conclusions: The prenatal ethanol exposure induced neuroapoptosis and neuron loss will persist into postnatal stage, and the long-term effect of neuroapoptosis might be one of the causes of postnatal neurobehavioural disturbances associated with fetal alcohol syndrome. [ABSTRACT FROM AUTHOR]
- Published
- 2007
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