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1. Effect of S-adenosyl-L-methionine administration on red blood cell cysteine and glutathione levels in alcoholic patients with and without liver disease.

Author

Loguercio C, Nardi G, Argenzio F, Aurilio C, Petrone E, Grella A, Del Vecchio Blanco C, and Coltorti M

Subjects
Adult, Alcoholism blood, Erythrocytes metabolism, Humans, Liver Cirrhosis, Alcoholic blood, Liver Function Tests, Male, Middle Aged, Alcoholism rehabilitation, Cysteine blood, Erythrocytes drug effects, Glutathione blood, Liver Cirrhosis, Alcoholic rehabilitation, S-Adenosylmethionine administration & dosage
Abstract

We measured glutathione and cysteine concentrations in erythrocytes of chronic alcohol misusers with (20 subjects) and without liver cirrhosis (20 subjects). Glutathione levels were decreased, whereas those of cysteine were increased in all patients. Parenteral treatment with S-adenosylmethionine (SAME); (2 g daily in 250 ml 0.15 M NaCl for 15 days) corrected the erythrocyte thiol alterations. We conclude that parenteral treatment with SAME affects the metabolism of SH compounds in erythrocytes of alcoholic patients.

Published
1994

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