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Start Over Author "Kunos, George" Journal alcoholism: clinical and experimental research
9 results on '"Kunos, George"'

9. Upregulation of Cannabinoid Type 1 Receptors in Dopamine D2 Receptor Knockout Mice Is Reversed by Chronic Forced Ethanol Consumption

Author

Thanos, Panayotis K., Gopez, Vanessa, Delis, Foteini, Michaelides, Michael, Grandy, David K., Wang, Gene‐Jack, Kunos, George, and Volkow, Nora D.

Abstract

Background: The anatomical proximity of the cannabinoid type 1 (CNR1/CB1R) and the dopamine D2 receptors (DRD2), their ability to form CB1R–DRD2 heteromers, their opposing roles in locomotion, and their involvement in ethanol’s reinforcing and addictive properties prompted us to study the levels and distribution of CB1R after chronic ethanol intake, in the presence and absence of DRD2.

Published
2011
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