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Background: Individuals with fetal alcohol spectrum disorders (FASDs) can experience profoundimpairments and long-term adverse outcomes. This systematic review adopts a life span perspectiveproviding an extensive analysis of the available literature. Methods: Studies were identified from PsycInfo, PubMed, Scopus, Web of Knowledge, CINAHL,ERIC, The Cochrane Central Register of Controlled Trials, and gray literature. Two reviewers independentlyscreened the title and abstract of each reference, and the methodological rigor of the includedstudies was assessed using the Effective Public Health Project assessment tool. Results: Thirty-two studies met the inclusion criteria, of which the vast majority targeted early tomiddle childhood. Two studies focused on early intervention in the postnatal period, and 6 studiesaimed to improve attention and/or self-regulation in childhood. Three of these provided promising evidenceon improving self-regulatory difficulties for children with FASDs. Nine studies focused onimproving specific areas of dysfunction. Six studies addressed social skills; 3 of these used an adaptationof a well-validated social skills program. Three studies provided promising initial evidence that parentsand caregivers could benefit from support with child behavior and a further 4 studies provided educationand advocacy for parents/caregivers, teachers, or child welfare workers. The final 2 studies wereaimed at supporting parents who were themselves affected by prenatal alcohol exposure. Conclusions: There is growing evidence for interventions that improve outcomes for early to middlechildhood. However, a lack of research exists outside of this developmental period. This lack ofresearch is concerning given the potential positive impact of early intervention, for individuals and,financially, for governments. In addition, the lack of interventions for adolescents and adults furtherhighlights the widening developmental gap and the potential influence of secondary disabilities for thisat-risk population. Refereed/Peer-reviewed