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Summary: Background: Metabolic dysfunction‐associated steatotic liver disease (MASLD) is the most common cause of chronic liver disease. Its prevalence is increasing with the epidemic of obesity and metabolic syndrome. MASLD progression into metabolic dysfunction‐associated steatohepatitis (MASH) and advanced fibrosis may lead to decompensated cirrhosis and development of liver‐related events, hepatocellular carcinoma and death. Monitoring disease progression is critical in decreasing morbidity, mortality, need for transplant and economic burden. Assessing for treatment response once FDA‐approved medications are available is still an unmet clinical need. Aims: To explore the most up‐to‐date literature on testing used for monitoring disease progression and treatment response Methods: We searched PubMed from inception to 15 August 2023, using the following MeSH terms: 'MASLD', 'Metabolic dysfunction‐associated steatotic liver disease', 'MASH', 'metabolic dysfunction‐associated steatohepatitis', 'Non‐Alcoholic Fatty Liver Disease', 'NAFLD', 'non‐alcoholic steatohepatitis', 'NASH', 'Biomarkers', 'clinical trial'. Articles were also identified through searches of the authors' files. The final reference list was generated based on originality and relevance to this review's broad scope, considering only papers published in English. Results: We have cited 101 references in this review detailing methods to monitor MASLD disease progression and treatment response. Conclusion: Various biomarkers can be used in different care settings to monitor disease progression. Further research is needed to validate noninvasive tests more effectively. [ABSTRACT FROM AUTHOR]

Summary: Background: Although enteropathy due to angiotensin II receptor blockers (ARBs) has been known for over 10 years, clinicians' awareness of this condition is still low. Aims: To systematically review the literature about clinical phenotypes, distribution of mucosal changes throughout the gastrointestinal tract and prognosis of enteropathy due to ARBs. Methods: According to PRISMA guidelines, we searched PubMed and Embase for relevant articles up to November 6, 2023. We included full‐text papers, letters, case reports and case series describing enteropathy due to ARBs. Patients were classified into subgroups based on endoscopic and histological findings of different regions of the gastrointestinal tract. The protocol was registered with Open Science Framework (https://doi.org/10.17605/OSF.IO/TK67C). Results: We included 94 articles reporting 183 cases (101 female, mean age at diagnosis 69 ± 10 years). The clinical picture at diagnosis was characterised by severe diarrhoea (97%) and weight loss (84%, median −13 kg), leading to hospital admission in 167 (95%) patients. Olmesartan (90%) was most frequently implicated. Villous atrophy (VA) was reported in 164/183 (89%) patients. One hundred and nine had only VA, 12 had pan‐gastrointestinal involvement, 23 had VA and gastric involvement and 19 had VA and colon involvement (predominantly microscopic colitis). Outcomes were reported for 178/183 (97%) patients, who all recovered clinically on ARBs withdrawal. Histological recovery occurred in all 96 patients with VA at baseline who underwent follow‐up duodenal biopsy. Conclusions: Enteropathy due to ARBs is characterised by severe malabsorption often requiring hospital admission and can involve the entire gastrointestinal tract. Clinician awareness can lead to prompt diagnosis and excellent prognosis. [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Lin et al papers. To view these articles, visit https://doi.org/10.1111/apt.17915 and https://doi.org/10.1111/apt.17971 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Coelho et al papers. To view these articles, visit https://doi.org/10.1111/apt.17950 and https://doi.org/10.1111/apt.17978 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Jost‐Brinkmann et al papers. To view these articles, visit https://doi.org/10.1111/apt.17441 and https://doi.org/10.1111/apt.18008 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Verma et al papers. To view these articles, visit https://doi.org/10.1111/apt.17891 and https://doi.org/10.1111/apt.17913 [ABSTRACT FROM AUTHOR]

Background: Standard clinical methods of assessing volume and providing resuscitation are not always applicable to patients with advanced or decompensated cirrhosis. Despite this being well known from a clinical perspective, there remains relatively little evidence to guide clinicians though fluid management in patients with cirrhosis and, often, multi-organ system dysfunction. Aims: This review summarises the current understanding of the circulatory dysfunction in cirrhosis, modalities for assessing volume status, and considerations for fluid selection. It additionally provides a practical approach to fluid resuscitation. Methods: We review current literature on cirrhosis pathophysiology in steady-state and shock, clinical implications of fluid resuscitation, and strategies to assess intravascular volume. Literature reviewed here was identified by the authors through PubMed search and review of selected papers' references. Results: Clinical management of resuscitation in advanced cirrhosis remains relatively stagnant. Although several trials have attempted to establish the superior resuscitative fluid, the lack of improvement in hard clinical outcomes leaves clinicians without clear guidance. Conclusions: The absence of consistent evidence for fluid resuscitation in patients with cirrhosis limits our ability to produce a clearly evidence-based protocol for fluid resuscitation in cirrhosis. However, we propose a preliminary practical guide to managing fluid resuscitation in patients with decompensated cirrhosis. Further studies are needed to develop and validate volume assessment tools in the specific context of cirrhosis, while randomised clinical trials of protocolized resuscitation may improve care of this patient population. [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Armandi et al papers. To view these articles, visit https://doi.org/10.1111/apt.17941 and https://doi.org/10.1111/apt.18064 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Armandi et al papers. To view these articles, visit https://doi.org/10.1111/apt.17941 and https://doi.org/10.1111/apt.18119 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Mathias et al papers. To view these articles, visit https://doi.org/10.1111/apt.18029 and https://doi.org/10.1111/apt.18100 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to García et al papers. To view these articles, visit https://doi.org/10.1111/apt.17938 and https://doi.org/10.1111/apt.18056. [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Fukuda et al papers. To view these articles, visit https://doi.org/10.1111/apt.18013 and https://doi.org/10.1111/apt.18094 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Fukuda et al papers. To view these articles, visit https://doi.org/10.1111/apt.18013 and https://doi.org/10.1111/apt.18111 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Tran et al papers. To view these articles, visit https://doi.org/10.1111/apt.18024 and https://doi.org/10.1111/apt.18046. [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Mathias et al papers. To view these articles, visit https://doi.org/10.1111/apt.18029 and https://doi.org/10.1111/apt.18109 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to García et al papers. To view these articles, visit https://doi.org/10.1111/apt.17938 and https://doi.org/10.1111/apt.18104. [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Vuijk et al papers. To view these articles, visit https://doi.org/10.1111/apt.18019 and https://doi.org/10.1111/apt.18036 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Norgard et al paper. To view this article, visit https://doi.org/10.1111/apt.18014 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Tran et al papers. To view these articles, visit https://doi.org/10.1111/apt.18024 and https://doi.org/10.1111/apt.18065. [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Plotkin et al papers. To view these articles, visit https://doi.org/10.1111/apt.18028 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Ruiz‐Cobo et al paper. To view this article, visit https://doi.org/10.1111/apt.18020 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Beaton et al papers. To view these articles, visit https://doi.org/10.1111/apt.18003 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Vuijk et al papers. To view these articles, visit https://doi.org/10.1111/apt.18019 and https://doi.org/10.1111/apt.18043 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Vuijk et al papers. To view these articles, visit https://doi.org/10.1111/apt.18000 and https://doi.org/10.1111/apt.18033 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Hofer et al papers. To view these articles, visit https://doi.org/10.1111/apt.17908 and https://doi.org/10.1111/apt.18044. [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Yiu et al papers. To view these articles, visit https://doi.org/10.1111/apt.18006 and https://doi.org/10.1111/apt.18049 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Yiu et al papers. To view these articles, visit https://doi.org/10.1111/apt.18006 and https://doi.org/10.1111/apt.18057 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Gomez et al papers. To view these articles, visit https://doi.org/10.1111/apt.18004 and https://doi.org/10.1111/apt.18032 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Kim et al papers. To view these articles, visit https://doi.org/10.1111/apt.17989 and https://doi.org/10.1111/apt.18023. [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Gomez et al papers. To view these articles, visit https://doi.org/10.1111/apt.18004 and https://doi.org/10.1111/apt.18048 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Tamaki et al papers. To view these articles, visit https://doi.org/10.1111/apt.18015 and https://doi.org/10.1111/apt.18034 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Hofer et al papers. To view these articles, visit https://doi.org/10.1111/apt.17908 and https://doi.org/10.1111/apt.18067. [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Vuijk et al papers. To view these articles, visit https://doi.org/10.1111/apt.18000 and https://doi.org/10.1111/apt.18053 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Tamaki et al papers. To view these articles, visit https://doi.org/10.1111/apt.18015 and https://doi.org/10.1111/apt.18047 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Kim et al papers. To view these articles, visit https://doi.org/10.1111/apt.17989 and https://doi.org/10.1111/apt.18045. [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Tan et al paper. To view this article, visit https://doi.org/10.1111/apt.17914 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Aliu et al papers. To view these articles, visit https://doi.org/10.1111/apt.17988 and https://doi.org/10.1111/apt.18027. [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Lin et al papers. To view these articles, visit https://doi.org/10.1111/apt.17915 and https://doi.org/10.1111/apt.17965. [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Armandi et al papers. To view these articles, visit https://doi.org/10.1111/apt.17941 and https://doi.org/10.1111/apt.17969. [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Aliu et al papers. To view these articles, visit https://doi.org/10.1111/apt.17988 and https://doi.org/10.1111/apt.18031. [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Bergman et al papers. To view these articles, visit https://doi.org/10.1111/apt.17708 and https://doi.org/10.1111/apt.18010. [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Malham et al papers. To view these articles, visit https://doi.org/10.1111/apt.17994 and https://doi.org/10.1111/apt.18012. [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Malham et al papers. To view these articles, visit https://doi.org/10.1111/apt.17994 and https://doi.org/10.1111/apt.18026. [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Bergman et al. papers. To view these articles, visit https://doi.org/10.1111/apt.17708 and https://doi.org/10.1111/apt.18018. [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Schiepatti et al papers. To view these articles, visit https://doi.org/10.1111/apt.17855 and https://doi.org/10.1111/apt.17977. [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Enriquez et al paper. To view this article, visit https://doi.org/10.1111/apt.17931 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Trivedi et al paper. To view this article, visit https://doi.org/10.1111/apt.17944 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Schiepatti et al papers. To view these articles, visit https://doi.org/10.1111/apt.17855 and https://doi.org/10.1111/apt.18017. [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Lin et al papers. To view these articles, visit https://doi.org/10.1111/apt.17915 and https://doi.org/10.1111/apt.18021. [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Yoon et al paper. To view this article, visit https://doi.org/10.1111/apt.17909 [ABSTRACT FROM AUTHOR]