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LINKED CONTENT: This article is linked to Ikegami et al papers. To view these articles, visit https://doi.org/10.1111/apt.17387 and https://doi.org/10.1111/apt.17420 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Cardoso et al papers. To view these articles, visit https://doi.org/10.1111/apt.17650 and https://doi.org/10.1111/apt.17698 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Cardoso et al papers. To view these articles, visit https://doi.org/10.1111/apt.17650 and https://doi.org/10.1111/apt.17725 [ABSTRACT FROM AUTHOR]

Aim To perform a meta-analysis is of published literature reporting standardized mortality ratios (SMR) for Crohn’s patients from 1970 to date. Methods Medline search identified relevant papers. Exploding references identified additional papers. When two papers reviewed mortality of one patient group at different times, the later publication was used. Results Of 13 papers identified, three studies reported SMR below 1.0, two others had confidence intervals including 1.0. All other studies reported mortality higher than the general population. Meta-analysis using a random effects model shows the pooled estimate for SMR in Crohn’s disease is 1.52 (95% CI: 1.32 to 1.74 [ P < 0.0001]). Meta-regression shows the SMR for these patients has decreased slightly over the past 30 years, but this decrease is not statistically significant ( P = 0.08). Conclusion Assessing evidence from original studies and conducting a meta-analysis shows age-adjusted mortality risk from Crohn’s disease is over 50% greater than the general population. Whilst mortality has improved since the condition was first recognized, further evaluation of the patients studied in the cohorts included here is necessary to assess more recent changes in clinical practice. [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Wong et al papers. To view these articles, visit https://doi.org/10.1111/apt.17195 and https://doi.org/10.1111/apt.17244 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Becchetti et al papers. To view these articles, visit https://doi.org/10.1111/apt.17192 and https://doi.org/10.1111/apt.17258 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Kumar et al paper. To view this article, visit https://doi.org/10.1111/apt.18188 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Schultheiss et al papers. To view these articles, visit https://doi.org/10.1111/apt.16605 and https://doi.org/10.1111/apt.16648 [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Dunne et al paper. To view this article, visit https://doi.org/10.1111/apt.15797. [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Kumar et al papers. To view these articles, visit https://doi.org/10.1111/apt.16839 and https://doi.org/10.1111/apt.16878 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Colman et al papers. To view these articles, visit https://doi.org/10.1111/apt.16733 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Nørgård et al papers. To view this article, visit https://doi.org/10.1111/apt.18014. [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Farina et al paper. To view this article, visit https://doi.org/10.1111/apt.17463 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Sorda et al papers. To view these articles, visit https://doi.org/10.1111/apt.16618 and https://doi.org/10.1111/apt.16657 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Khan et al papers. To view these articles, visit https://doi.org/10.1111/apt.16610 and https://doi.org/10.1111/apt.16738 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Schultheiss et al papers. To view these articles, visit https://doi.org/10.1111/apt.16605 and https://doi.org/10.1111/apt.16722 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Younossi et al papers. To view these articles, visit https://doi.org/10.1111/apt.17346 and https://doi.org/10.1111/apt.17422 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Younossi et al papers. To view these articles, visit https://doi.org/10.1111/apt.17346 and https://doi.org/10.1111/apt.17448 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Goodoory et al papers. To view these articles, visit https://doi.org/10.1111/apt.17356 and https://doi.org/10.1111/apt.17391 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Vaishnav et al papers. To view these articles, visit https://doi.org/10.1111/apt.17868 and https://doi.org/10.1111/apt.17976 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Vaishnav et al papers. To view these articles, visit https://doi.org/10.1111/apt.17868 and https://doi.org/10.1111/apt.17982 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Yoon et al paper. To view this article, visit https://doi.org/10.1111/apt.17909 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Martini et al papers. To view these articles, visit https://doi.org/10.1111/apt.17804 and https://doi.org/10.1111/apt.17901 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Martini et al papers. To view these articles, visit https://doi.org/10.1111/apt.17804 and https://doi.org/10.1111/apt.17916 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Cash et al paper. To view this article, visit https://doi.org/10.1111/apt.16702 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Kulyk et al papers. To view these articles, visit https://doi.org/10.1111/apt.17241 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Wong et al papers. To view these articles, visit https://doi.org/10.1111/apt.17195 and https://doi.org/10.1111/apt.17323 [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Feagan et al paper. To view this article, visit https://doi.org/10.1111/apt.14997. [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Artru et al and Debnath & Rathi papers. To view these articles, visit https://doi.org/10.1111/apt.16080 and https://doi.org/10.1111/apt.16127 [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Choudhary et al papers. To view these articles, visit https://doi.org/10.1111/apt.17104 and https://doi.org/10.1111/apt.17134 [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Rosiou et al papers. To view these articles, visit https://doi.org/10.1111/apt.17039 and https://doi.org/10.1111/apt.17140 [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Tergast et al papers. To view these articles, visit https://doi.org/10.1111/apt.16831 and https://doi.org/10.1111/apt.17157 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Khan et al papers. To view these articles, visit https://doi.org/10.1111/apt.16610 and https://doi.org/10.1111/apt.16707 [ABSTRACT FROM AUTHOR]

Background A better understanding of predictors of risk for pancreatic ductal adenocarcinoma (PDAC) could inform preventive efforts against this lethal cancer. While aspirin (ASA) and non-steroidal anti-inflammatory drugs (NSAIDS) might protect against several gastrointestinal cancers, their role in the development of PDAC remains unclear. Aim To conduct a systematic review and meta-analysis on the relation between ASA/NSAIDs exposure and the risk of PDAC. Methods We searched Pubmed, Embase, Scopus, Cochrane database of systematic reviews and reference lists of identified papers and included observational (cohort or case-control) studies and randomized controlled trials examining exposure to ASA and/or NSAIDs and the incidence or mortality of PDAC. We defined three categories (low, intermediate, high), based on exposure duration and dose. Results Eight studies fulfilled our inclusion criteria (four cohort, three case controls, and one randomized controlled trial studies) enrolling 6301 patients between 1971–2004; all but one study took place in the US. The pooled OR were 0.99 (0.83–1.19), 1.11 (0.84–1.47) and 1.09 (0.67–1.75) in the low, intermediate and high exposure groups respectively, with considerable heterogeneity (I2 ranging 60–86%). Sensitivity analysis by ASA use only, study design or sex did not reveal additional important information. Conclusions This study did not show an association between ASA/NSAIDs and PDAC. The large baseline exposure in controls in North-America may have obscured an association. There is need for additional studies, especially in Europe, to clarify this issue. [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Taxonera et al papers. To view these articles, visit https://doi.org/10.1111/apt.15804 and https://doi.org/10.1111/apt.15955 [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Dulai et al and Verstockt and Ferrante papers. To view these articles, visit https://doi.org/10.1111/apt.15609 and https://doi.org/10.1111/apt.15634. [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Dulai et al and Dulai papers. To view these articles, visit https://doi.org/10.1111/apt.15609 and https://doi.org/10.1111/apt.15671. [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Bernstein et al and Veyrard et al papers. To view these articles, visit https://doi.org/10.1111/apt.16518 and https://doi.org/10.1111/apt.16541 [ABSTRACT FROM AUTHOR]

Linked Content This article is linked to Le et al papers. To view these articles visit https://doi.org/10.1111/apt.14326 and https://doi.org/10.1111/apt.14241. [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Kumar et al papers. To view these articles, visit https://doi.org/10.1111/apt.16839 and https://doi.org/10.1111/apt.16918 [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Armstrong et al paper. To view this article, visit https://doi.org/10.1111/apt.15164. [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Sorda et al papers. To view these articles, visit https://doi.org/10.1111/apt.16618 and https://doi.org/10.1111/apt.16726 [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Tergast et al papers. To view these articles, visit https://doi.org/10.1111/apt.17066 and https://doi.org/10.1111/apt.17099 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Bunchorntavakul & Reddy and Alexopoulos et al papers. To view these articles, visit https://doi.org/10.1111/apt.15571 and https://doi.org/10.1111/apt.16564 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Bunchorntavakul & Reddy papers. To view these articles, visit https://doi.org/10.1111/apt.15571 and https://doi.org/10.1111/apt.16581 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Bernstein et al papers. To view these articles, visit https://doi.org/10.1111/apt.16518 and https://doi.org/10.1111/apt.16554 [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Nicholson et al and Farrugia et al papers. To view these articles, visit https://doi.org/10.1111/apt.15969 and https://doi.org/10.1111/apt.16068 and https://doi.org/10.1111/apt.16082 [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Ponziani et al papers. To view these articles, visit https://doi.org/10.1111/apt.15996 and https://doi.org/10.1111/apt.16052 [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Ballou et al paper. To view this article, visit https://doi.org/10.1111/apt.15500. [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Mooers et al papers. To view these articles, visit https://doi.org/10.1111/apt.16457 and https://doi.org/10.1111/apt.16516 [ABSTRACT FROM AUTHOR]