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Your search keyword '"Sbrana, S."' showing total 3 results
Start Over Author "Sbrana, S." Journal allergie et immunologie
3 results on '"Sbrana, S."'

1. In vitro effects of an immunoglobulin preparation for intravenous use (IVIG) on T-cells activation

Author

Sbrana, S., LUCIA RUOCCO, Vanacore, R., Azzara, A., and Ambrogi, F.

Subjects
T-Lymphocytes, Osmolar Concentration, Dose-Response Relationship, Immunologic, Humans, Immunoglobulins, Intravenous, Phytohemagglutinins, Lymphocyte Activation, Cells, Cultured
Abstract

The "in vitro" effect of different concentrations of polyclonal human immunoglobulins for intravenous use (IVIG) on cultured T-lymphocyte response to phytohemagglutinin (PHA) was evaluated. Four dilutions of IVIG corresponding with the "in vitro" doses currently employed in therapy have been tested by the effect on PHA stimulated cultures. The dilution of IVIG corresponding with a low therapeutical dose gives a higher statistically significant stimulating effect. The results obtained in our work agree with previous studies performed on activated B-cells. We can suppose the immunoglobulins may control the T-lymphocyte activation either by a direct link with a specific Fc-receptor expressed on the surface of activated T-cell or by affecting the cytokines release from monocyte cells.

Published
1993

2. Mycobacterial infection in HIV+ patients detected with a new immunological method (TB test).

Author

Vanacore R, Paladini A, Ceretelli S, Savalli E, Sbrana S, Falsini R, Scasso A, and Ambrogi F

Subjects
AIDS-Related Opportunistic Infections complications, AIDS-Related Opportunistic Infections microbiology, Antibodies, Bacterial immunology, Humans, Mycobacterium Infections complications, Mycobacterium Infections microbiology, Mycobacterium Infections, Nontuberculous complications, Mycobacterium Infections, Nontuberculous diagnosis, Mycobacterium Infections, Nontuberculous microbiology, Mycobacterium tuberculosis immunology, Tuberculosis, Pulmonary complications, Tuberculosis, Pulmonary diagnosis, Tuberculosis, Pulmonary microbiology, AIDS-Related Opportunistic Infections diagnosis, Antibodies, Bacterial blood, Antigens, Bacterial immunology, Enzyme-Linked Immunosorbent Assay, HIV Seropositivity complications, Immunoglobulin G analysis, Membrane Glycoproteins immunology, Mycobacterium Infections diagnosis, Mycobacterium tuberculosis isolation & purification
Abstract

Antibody response to antigen A60 (a mycobacterial antigen) was evaluated in ELISA in 18 HIV+ subjects with clinical and cultural evidences of mycobacterial infections, in 10 HIV+ subjects without Mycobacterial infections and in 22 healthy donors. We found higher levels of specific IgG in the HIV+ patients with Mycobacterial infections (mean 179.2 +/- 83 U) compared to the values of the donors (mean 92.5 +/- 35.5 U: p < 0.01). This test may be useful in the diagnosis of tuberculosis, but it needs clinical validation.

Published
1993

3. IgE modification of the specific antidermatophagoides during the first year of specific immunotherapy (SIT).

Author

Vanacore R, Ferrara MP, Berni R, Luchetti A, Gianfaldoni ML, Sbrana S, and Ambrogi F

Subjects
Adolescent, Adult, Allergens administration & dosage, Allergens immunology, Animals, Antigens, Dermatophagoides, Delayed-Action Preparations, Dust, Female, Fluorescent Antibody Technique, Humans, Immunoenzyme Techniques, Injections, Subcutaneous, Male, Rhinitis, Allergic, Perennial immunology, Allergens therapeutic use, Desensitization, Immunologic, Immunoglobulin E blood, Mites immunology, Rhinitis, Allergic, Perennial therapy
Abstract

Six subjects (4 female, 2 male), aged from 16 to 25 years, presented with allergic rhinitis to Dermatophagoides mites and received SIT by the sub-cutaneous route with delayed-release alpha fraction Bayropharm at the standard doses. Diagnosis was based on clinical history, skin tests and measurement of specific IgE at 0, 3, 9, and 12 months, by the fluoro-enzymatic technique (FAST). For comparison, in a reference group (n = 20) the IgE varied between 0.32 and 0.11 IU/ml for D1 and 0.31 to 0.09 IU/ml for D2. The eight patients had specific IgE titres of D1 = 0.96, D2 = 0.99. For these authors, the FAST technique used for the measurement of specific IgE, although less sensitive than the RIA technique of RAST, gives a good evaluation of SIT.

Published
1992

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