1. Thymus and activation-regulated chemokine (TARC/CCL17) predicts decline of pulmonary function in patients with chronic obstructive pulmonary disease
- Author
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Hiroaki Murano, Takako Nemoto, Kento Sato, Keiko Yamauchi, Koya Abe, Yoko Shibata, Sumito Inoue, Hiroyoshi Machida, Akira Igarashi, Masamichi Sato, Masafumi Watanabe, Sujeong Yang, Michiko Nishiwaki, Yoshikane Tokairin, Tomomi Kimura, Hiroshi Nakano, and Chisa Sato
- Subjects
lcsh:Immunologic diseases. Allergy ,0301 basic medicine ,Male ,Chemokine ,medicine.medical_specialty ,Percentile ,Pulmonary function ,Multivariate analysis ,Chronic obstructive pulmonary disease (COPD) ,Logistic regression ,Gastroenterology ,Severity of Illness Index ,Pulmonary function testing ,03 medical and health sciences ,Pulmonary Disease, Chronic Obstructive ,0302 clinical medicine ,Th2 Cells ,Thymus and activation-regulated chemokine (TARC/CCL17) ,Internal medicine ,medicine ,Immunology and Allergy ,CCL17 ,Humans ,COPD ,biology ,business.industry ,Biomarker ,General Medicine ,respiratory system ,medicine.disease ,Prognosis ,respiratory tract diseases ,Respiratory Function Tests ,Forxed expiratory volume in one second (FEV1) ,030104 developmental biology ,030228 respiratory system ,ROC Curve ,biology.protein ,Biomarker (medicine) ,Female ,Chemokine CCL17 ,Chemokines ,Inflammation Mediators ,lcsh:RC581-607 ,business ,Biomarkers - Abstract
Background The deterioration of pulmonary function, such as FEV1-decline, is strongly associated with poor prognosis in patients with chronic obstructive pulmonary disease (COPD). However, few investigations shed light on useful biomarkers for predicting the decline of pulmonary function. We evaluated whether thymus and activation-regulated chemokine (TARC), a Th2 inflammation marker, could predict rapid FEV1-decline in COPD patients. Methods We recruited 161 patients with stable COPD and performed pulmonary function test once every six months. At the time of registration, blood tests, including serum levels of TARC were performed. We assessed the correlation between changes in parameters of pulmonary function tests and serum levels of TARC. The rapid-decline in pulmonary function was determined using 25th percentile of change in FEV1 or FEV1 percent predicted (%FEV1) per year. Results In the FEV1-rapid-decline group, the frequency of exacerbations, the degree of emphysema, and serum levels of TARC was higher than in the non-rapid-decline group. When using %FEV1 as a classifier instead of FEV1, age, the frequency of exacerbations, the degree of emphysema and serum levels of TARC in the rapid-decline group was significantly greater than those in the non-rapid-decline group. In univariate logistic regression analysis, TARC was the significant predictive factor for rapid-decline group. In multivariate analysis adjusted for emphysema, serum levels of TARC are independently significant predicting factors for the rapid-decline group. Conclusions TARC is an independent predictive biomarker for the rapid-decline in FEV1. Measuring serum TARC levels may help the management of COPD patients by predicting the risk of FEV1 decline.
- Published
- 2020