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Your search keyword '"Francesco Tovoli"' showing total 3 results
Start Over Author "Francesco Tovoli" Journal allergy, asthma & clinical immunology
3 results on '"Francesco Tovoli"'

2. Autoantibodies to speckled protein family in primary biliary cholangitis

Author

Alessandro Granito, Luigi Muratori, Francesco Tovoli, and Paolo Muratori

Subjects
Speckled proteins, Multiple nuclear dots, Antinuclear antibodies, Primary biliary cholangitis, Immunologic diseases. Allergy, RC581-607
Abstract

Abstract The autoantibody profile of primary biliary cholangitis (PBC) includes antinuclear antibodies (ANA) which are detectable by indirect immunofluorescence in more than 50% of PBC patients. One of the two immunofluorescence patterns which are historically considered “PBC-specific” is the so-called “multiple nuclear dots” (MND) targeting nuclear body proteins such as Sp100, Sp140, Sp140L proteins, promyelocytic leukemia protein (PML) and small ubiquitin-related modifier proteins (SUMO). It has been hypothesized a role of nuclear body protein alterations in immune disorders such as PBC, thus suggesting novel and more refined therapeutic approaches.

Published
2021
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3. Autoantibodies to speckled protein family in primary biliary cholangitis

Author

Luigi Muratori, Francesco Tovoli, Alessandro Granito, Paolo Muratori, Granito A., Muratori L., Tovoli F., and Muratori P.

Subjects
lcsh:Immunologic diseases. Allergy, Allergy, Anti-nuclear antibody, Protein family, Nuclear dots, Immunofluorescence, digestive system, Speckled proteins, Promyelocytic leukemia protein, Immune system, Medicine, Multiple nuclear dot, skin and connective tissue diseases, Letter to the Editor, medicine.diagnostic_test, biology, business.industry, Primary biliary cholangitis, Autoantibody, General Medicine, medicine.disease, digestive system diseases, Antinuclear antibodies, Primary biliary cholangiti, Immunology, biology.protein, lcsh:RC581-607, Multiple nuclear dots, business, Antinuclear antibodie
Abstract

The autoantibody profile of primary biliary cholangitis (PBC) includes antinuclear antibodies (ANA) which are detectable by indirect immunofluorescence in more than 50% of PBC patients. One of the two immunofluorescence patterns which are historically considered “PBC-specific” is the so-called “multiple nuclear dots” (MND) targeting nuclear body proteins such as Sp100, Sp140, Sp140L proteins, promyelocytic leukemia protein (PML) and small ubiquitin-related modifier proteins (SUMO). It has been hypothesized a role of nuclear body protein alterations in immune disorders such as PBC, thus suggesting novel and more refined therapeutic approaches.

Published
2021

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