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This article is a reply to the European Academy of Allergy and Clinical Immunology's guidelines on anaphylaxis. The authors suggest that Kounis syndrome (KS), which is an acute coronary syndrome secondary to anaphylaxis, should be included in the clinical picture of anaphylaxis. They explain that KS can present as vasospastic angina, myocardial infarction, stent thrombosis, or stent restenosis, and it is associated with a higher mortality rate compared to anaphylaxis without KS. The authors emphasize the importance of early recognition and management of KS and recommend its inclusion in future guidelines on anaphylaxis. [Extracted from the article]

This article summarizes a study that used single-cell RNA sequencing to analyze human blood eosinophils and their relationship to asthma. The study found no clear evidence of distinct subpopulations of eosinophils in the blood, but observed differences in gene expression related to activation states and immune response pathways. The study suggests that eosinophils may acquire different characteristics after being localized in tissues. However, the sample size was small, and further research is needed to explore the relationship between eosinophils and asthma in more diverse populations. The study was supported by various funding sources and the authors declare their conflicts of interest. The data from the study are available upon request from the corresponding author. [Extracted from the article]