1. Hereditary angioedema: special consideration in children, women of childbearing age, and the elderly.
- Author
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Kuhlen JL and Banerji A
- Subjects
- Age Factors, Aged, Angioedemas, Hereditary epidemiology, Angioedemas, Hereditary etiology, Child, Female, Humans, Pregnancy, Prognosis, Risk Factors, Sex Factors, Angioedemas, Hereditary diagnosis, Angioedemas, Hereditary therapy
- Abstract
This review on hereditary angioedema (HAE) focused on special topics regarding HAE in children, women of childbearing age, and the elderly. HAE is a rare autosomal dominant bradykinin-mediated disorder characterized by recurrent attacks of subcutaneous or submucosal swelling that usually affects the face, upper airway, extremities, gastrointestinal tract, or genitalia. These recurrent attacks cause significant morbidity and can be life threatening, especially when the swelling affects the airway. Our objective was to summarize the published data available on the disease epidemiology, pathophysiology, clinical presentation, on demand and prophylactic therapy, and focus on management considerations for these special patient populations. Unique aspects of HAE in women with regard to contraception, hormone replacement therapy, pregnancy, lactation, and menopause were also reviewed.
- Published
- 2015
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