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Background: The CSF tap test evaluation vary a lot in different medical center, which result in the wide range of sensitivity. Our study aimed to explore the effect of multi time point and multiple domain evaluation on the determination of CSF tap test results in patients with normal pressure hydrocephalus. Method: A total of 150 outpatients with NPH 2013‐2018 from the Department of Neurology of Peking Union Medical College Hospital were enrolled in this study. All patients underwent detailed neuropsychological (MMSE, MOCA, Trail Making Test , Digital Symbol, Stroop‐c test, Grooved pegboard test) and walking ability (10 meter walking test, 5 meter up and go test), and head MRI examination. Patients who did not complete the four time point's evaluation of CSF tap test to eliminate severe dementia and various reasons. The positive criteria were that the performance of either time or steps in walking test was 20% higher than the baseline level, or both were 10% higher. In the cognitive test, the score of any test is 20% higher than the baseline as a positive criterion. According to this standard, the positive rates of each evaluation test and three evaluation time points were calculated and compared. Result: The positive rate of 5 meter up and go test on 8 hours, 24 hours and 72 hours after CSF tap test was 40.6%, 42.0%, 48.9%, the positive rate of 10‐meter walking test was 35.8%, 30.9%, 40.7% respectively; the positive rate of Digital Symbol was 23.8%, 38.1%, 42.9% respectively; the positive rate of Trail Making T test was 38.7%, 45%, 57.9%; the positive rates of Stroop‐c performance were 27.0%, 39.3% and 49.1% respectively; the positive rates of Grooved pegboard test on 8 hours, 24 hours and 72 hours after CSF tap test were 25%, 27.9% and 39.7%. Conclusion: The positive rate of 5 meter up and go test is higher than that of 10 meter walking test, and the positive rate of 24‐hour and 72 hour comprehensive evaluation combined with walk and cognitive evaluation is higher. [ABSTRACT FROM AUTHOR]

Background: The CSF tap test evaluation needs repetitive test of walking ability and cognition. Our study aimed to explore the changes of cognitive function and the influence of learning effect on the results in CSF tap test when evaluating the patients with normal pressure hydrocephalus (NPH). Method: CSF tap test was carried out in 134 patients with NPH 2013‐2018 in neurology clinic of Peking Union Medical College Hospital. All patients underwent detailed neuropsychological evaluation (MMSE, MOCA, Trail Making test, Digital symbol, Stroop‐c test) and walking ability (10 meter walking test, up and go test), and head MRI examination. Patients who did not complete the four time point evaluations of CSF tap test due to severe dementia or any other reasons were excluded. Nonparametric test was used to test the difference of z‐scores of executive function (including connection test, number sign and shop‐c test) between the baseline and the four time points after CSF tap test. According to the baseline MMSE scores, the subjects were divided into MMSE > = 26 and MMSE < 26 groups. The changes of z‐scores of three executive function tests were observed in the group. Result: Compared with the baseline, the Z‐score of executive function began to improve at 24 hours and 72 hours, and there was a statistically significant difference (P 0.001 and 0.000, respectively). Within the MMSE > = 26 group, there was a significant improvement in executive function at 24 hours and 72 hours compared with baseline (P <0.05). In the group with MMSE < 26, the executive function Z‐score at 72 hours was significantly improved compared with that at baseline (P = 0.000), while the improvement at 8 hours and 24 hours was not significant. Conclusion: It was found that the executive function of CSF was improved with different evaluation points. According to the classification of MMSE scores, it was found that patients with different cognitive states had different characteristics of executive function curve, which could not be explained by learning effect. [ABSTRACT FROM AUTHOR]