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51 results on '"Daniela Galimberti"'

1. Shorter disease duration in females with sporadic frontotemporal dementia

Author

Sterre C.M. de Boer, Lina Riedl, Sven J Van der lee, Markus Otto, Sarah Anderl‐Straub, Ramon Landin‐Romero, Federica Sorrentino, Jay L.P. Fieldhouse, Lianne M. Reus, Glenda M Halliday, Daniela Galimberti, Janine Diehl‐Schmid, Simon Ducharme, Olivier Piguet, and Yolande A.L. Pijnenburg

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2022

3. Protective association of HLA‐DRB1 *04 subtypes in neurodegenerative diseases implicates acetylated tau PHF6 sequences

Author

Yann Le Guen, Guo Luo, Aditya Ambati, Vincent Damotte, Iris E Jansen, Eric Yu, Aude Nicolas, Itziar de Rojas, Thiago Peixoto Leal, Akinori Miyashita, Céline Bellenguez, Michelle Mulan Lian, Kayenat Parveen, Takashi Morizono, Hyeonseul Park, Benjamin Grenier‐Boley, Tatsuhiko Naito, Fahri Küçükali, Seth D. Talyansky, Selina Marie Yogeshwar, Vicente Sempere, Wataru Satake, Victoria Álvarez‐Martínez, Beatrice Arosio, Michael E Belloy, Luisa Benussi, Anne Boland, Barbara Borroni, María J. Bullido, Paolo Caffarra, Jordi Clarimon, Antonio Daniele, Daniel Darling, Stéphanie Debette, Jean‐François Deleuze, Martin Dichgans, Carole Dufouil, Emmanuel During, Emrah Duzel, Daniela Galimberti, Guillermo García‐Ribas, Jose María García‐Alberca, Pablo García‐González, Vilmantas Giedraitis, Oliver Goldhardt, Caroline Graff, Edna Grunblatt, Olivier Hanon, Lucrezia Hausner, Stefanie Heilmann‐Heimbach, Henne Holstege, Jakub Hort, Yoo Jin Jung, Deckert Jurgen, Silke Kern, Teemu Kuulasmaa, Kun Ho Lee, Ling Ling, Carlo Masullo, Patrizia Mecocci, Shima Mehrabian, Alexandre de Mendonça, Mercè Boada, Pablo Mir, Susanne Moebus, Fermin Moreno, Benedetta Nacmias, Gaël Nicolas, Shumpei Niida, Børge G. Nordestgaard, Goran Papenberg, Janne M. Papma, Lucilla Parnetti, Florence Pasquier, Pau Pastor, Oliver Peters, Yolande A.L. Pijnenburg, Gerard Piñol‐Ripoll, Julius Popp, Laura Molina, Raquel Puerta, Jordi Pérez‐Tur, Innocenzo Rainero, Luis Miguel Real, Steffi G. Riedel‐Heller, Eloy Rodríguez Rodríguez, José Luís Royo, Dan Rujescu, Nikolaos Scarmeas, Philip Scheltens, Norbert Scherbaum, Anja Schneider, Davide Seripa, Ingmar Skoog, Vincenzo Solfrizzi, Gianfranco Spalletta, Alessio Squassina, John C van Swieten, Raquel Sanchez‐Valle, Eng‐King Tan, Thomas Tegos, Charlotte E. Teunissen, Jesper Qvist Thomassen, Lucio Tremolizzo, Martin Vyhnalek, Frans R.J. Verhey, Margda Waern, Jens Wiltfang, Jing Zhang, Henrik Zetterberg, Kaj Blennow, Julie Williams, Philippe Amouyel, Frank Jessen, Patrick G Kehoe, Ole Andreassen, Cornelia M van Duijn, Magda Tsolaki, Pascual Sanchez‐Juan, Ruth Frikke‐Schmidt, Kristel Sleegers, Tatsushi Toda, Anna Zettergren, Martin Ingelsson, Yukinori Okada, Giacomina Rossi, Mikko Hiltunen, Jungsoo Gim, Kouichi Ozaki, Rebecca Sims, Jia Nee Foo, Wiesje M. van der Flier, Takeshi Ikeuchi, Alfredo Ramirez, Ignacio Mata, Agustin Ruiz, Ziv Gan‐Or, Jean‐Charles Lambert, Michael D Greicius, and Emmanuel Mignot

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2022

4. Apathy in presymptomatic genetic frontotemporal dementia predicts cognitive decline and is driven by structural brain changes

Author

Matthis Synofzik, Alexandre de Mendonça, Giovanni B. Frisoni, Maura Malpetti, Fermin Moreno, Christopher C Butler, Roberta Ghidoni, Daniela Galimberti, Rik Vandenberghe, Elizabeth Finger, Isabel Santana, Alexander Gerhard, Georgia Peakman, Emily Todd, Carolin Heller, Jonathan D. Rohrer, Katrina M. Moore, Kamen A. Tsvetanov, Rhian S Convery, P. Simon Jones, Johannes Levin, James B. Rowe, Caroline Graff, Markus Otto, Barbara Borroni, Raquel Sánchez-Valle, Sandro Sorbi, Fabrizio Tagliavini, John C. van Swieten, Maria Carmela Tartaglia, Rogier A. Kievit, Simon Ducharme, Robert Laforce, Mario Masellis, Timothy Rittman, Adrian Danek, David M. Cash, Martina Bocchetta, Apollo - University of Cambridge Repository, Repositório da Universidade de Lisboa, Neurology, Malpetti, Maura [0000-0001-8923-9656], Jones, Simon [0000-0001-9695-0702], Tsvetanov, Kamen A. [0000-0002-3178-6363], Rittman, Timothy [0000-0003-1063-6937], and Rowe, James [0000-0001-7216-8679]

Subjects
Male, longitudinal design, SYMPTOMS, pathology [Cognitive Dysfunction], Epidemiology, Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13], Medizin, apathy, DISEASE, 0302 clinical medicine, pathology [Brain], pathology [Gray Matter], C9orf72, presymptomatic carriers, cognitive decline, genetic frontotemporal dementia, MRI, Apathy, Gray Matter, Cognitive decline, genetics [Frontotemporal Dementia], pathology [Atrophy], 0303 health sciences, Health Policy, Brain, Cognition, IMPAIRMENT, Middle Aged, DEPRESSION, Magnetic Resonance Imaging, Psychiatry and Mental health, Frontotemporal Dementia, Female, IMPULSIVITY, medicine.symptom, Life Sciences & Biomedicine, Clinical psychology, Frontotemporal dementia, Clinical Neurology, FEATURED ARTICLE, Prodromal Symptoms, PHENOTYPES, genetics [Mutation], Impulsivity, 03 medical and health sciences, Cellular and Molecular Neuroscience, All institutes and research themes of the Radboud University Medical Center, Atrophy, SDG 3 - Good Health and Well-being, Developmental Neuroscience, mental disorders, medicine, Humans, Dementia, Cognitive Dysfunction, ddc:610, BEHAVIORAL-VARIANT, 030304 developmental biology, Science & Technology, EXECUTIVE FUNCTION, business.industry, DIGIT SYMBOL, 1103 Clinical Sciences, medicine.disease, DYSFUNCTION, Geriatrics, Mutation, FEATURED ARTICLES, Neurosciences & Neurology, Neurology (clinical), Geriatrics and Gerontology, 1109 Neurosciences, business, 030217 neurology & neurosurgery
Abstract

© 2020 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited., Introduction: Apathy adversely affects prognosis and survival of patients with frontotemporal dementia (FTD). We test whether apathy develops in presymptomatic genetic FTD, and is associated with cognitive decline and brain atrophy. Methods: Presymptomatic carriers of MAPT, GRN or C9orf72 mutations (N = 304), and relatives without mutations (N = 296) underwent clinical assessments and MRI at baseline, and annually for 2 years. Longitudinal changes in apathy, cognition, gray matter volumes, and their relationships were analyzed with latent growth curve modeling. Results: Apathy severity increased over time in presymptomatic carriers, but not in non-carriers. In presymptomatic carriers, baseline apathy predicted cognitive decline over two years, but not vice versa. Apathy progression was associated with baseline low gray matter volume in frontal and cingulate regions. Discussion: Apathy is an early marker of FTD-related changes and predicts a subsequent subclinical deterioration of cognition before dementia onset. Apathy may be a modifiable factor in those at risk of FTD., This work is co‐funded by the UK Medical Research Council (MR/M023664/1), the Italian Ministry of Health and the Canadian Institutes of Health Research as part of a Centres of Excellence in Neurodegeneration grant, a Canadian Institutes of Health Research operating grant and the Bluefield Project, as well as a JPND grant “GENFI‐prox” (by DLR/BMBF to MS, joined with JDR, JvS, MO, BB and CG). MM is supported by the Cambridge Trust & Sidney Sussex College Scholarship. PSJ is supported by the Cambridge Centre for Parkinson Plus. KAT is supported by the British Academy Postdoctoral Fellowship (KAT: PF160048) and Guarantors of Brain (KAT: 101149). TR is supported by the Cambridge Centre for Parkinson Plus and Cambridge Biomedical Resource Centre. RAK is supported by Medical Research Council (RAK: SUAG/047/G101400). JBR reports grants from the NIHR Cambridge Biomedical research centre, Wellcome Trust (103838), and Medical Research Council (SUAG051/G101400; MR/T033371/1); personal fees from Asceneuron, WAVE, Astex, and Biogen; and grants from Janssen, AZ Medimmune, and Eli Lilly, outside the submitted work. JDR is supported by an MRC Clinician Scientist Fellowship (MR/M008525/1) and has received funding from the NIHR Rare Disease Translational Research Collaboration (BRC149/NS/MH). MB is supported by a Fellowship award from the Alzheimer's Society, UK (AS‐JF‐19a‐004‐517), and by the UK Dementia Research Institute which receives its funding from DRI Ltd, funded by the UK Medical Research Council, Alzheimer's Society, and Alzheimer's Research UK.

Published
2020

5. Differences in sex distribution between genetic and sporadic FTD

Author

Sterre C.M. de Boer, Sven J Van Der Lee, Janine Diehl‐Schmid, Lina Riedl, Olivier Piguet, Glenda M Halliday, Daniela Galimberti, Federica Sorrentino, Simon Ducharme, Jay L.P. Fieldhouse, Lianne M. Reus, and Yolande A.L. Pijnenburg

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2021

6. A data‐driven disease progression model of fluid biomarkers in genetic FTD

Author

Emma van der Ende, Esther E. Bron, Jackie M. Poos, Lize C. Jiskoot, Jessica L. Panman, Janne M. Papma, Carlo Wilke, Matthis Synofzik, Carolin Heller, Imogen J. Swift, Aitana Sogorb Esteve, Arabella Bouzigues, Barbara Borroni, Raquel Sanchez‐Valle, Fermin Moreno, Caroline Graff, Robert Laforce, Daniela Galimberti, Mario Masellis, Maria Carmela Tartaglia, Elizabeth Finger, Rik Vandenberghe, James B. Rowe, Alexandre Mendonca, Fabrizio Tagliavini, Isabel Santana, Simon Ducharme, Christopher Butler, Alexander Gerhard, Johannes Levin, Adrian Danek, Markus Otto, Yolande A.L. Pijnenburg, Giovanni B. Frisoni, Sandro Sorbi, Roberta Ghidoni, Wiro J. Niessen, Jonathan D. Rohrer, Stefan Klein, John C van Swieten, Vikram Venkatraghavan, and Harro Seelaar

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2021

7. A cognitive composite for genetic frontotemporal dementia: GENFI‐cog

Author

Jackie M. Poos, Jennifer M Nicholas, Katrina M Moore, Lucy L Russell, Georgia Peakman, Lize C. Jiskoot, Esther van den Berg, Janne M. Papma, Harro Seelaar, Yolande A.L. Pijnenburg, Fermin Moreno, Raquel Sanchez‐Valle, Barbara Borroni, Robert Laforce, Mario Masellis, Maria Carmela Tartaglia, Caroline Graff, Daniela Galimberti, James B Rowe, Elizabeth Finger, Matthis Synofzik, Rik Vandenberghe, Alexandre Mendonca, Fabrizio Tagliavini, Isabel Santana, Simon Ducharme, Christopher Butler, Alexander Gerhard, Johannes Levin, Adrian Danek, Markus Otto, John C van Swieten, and Jonathan D Rohrer

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2021

8. Dissecting frontotemporal dementia: Correlations between neuropsychiatric symptoms and neuropathology

Author

Harro Seelaar, Anke A. Dijkstra, Annemieke J.M. Rozemuller, Daniela Galimberti, Yolande A.L. Pijnenburg, Priya Gami-Patel, Netherlands Brain Bank, John C. van Swieten, Annemiek Dols, Marta Scarioni, Elio Scarpini, Jeroen J.M. Hoozemans, and Yannick Timar

Subjects
Pathology, medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Neuropathology, medicine.disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Medicine, Neurology (clinical), Geriatrics and Gerontology, business, Frontotemporal dementia
Published
2020

9. Phenotypic heterogeneity of the rare R377W PSEN1 mutation: Late‐onset presentation with mixed Alzheimer’s and frontotemporal dementia features

Author

Elio Scarpini, Giorgio G. Fumagalli, Chiara Fenoglio, Tiziana Carandini, Andrea Arighi, Daniela Galimberti, Emanuela Rotondo, Anna M. Pietroboni, Marta Scarioni, and Maria Serpente

Subjects
Genetics, Psen1 mutation, Epidemiology, Genetic heterogeneity, Health Policy, Late onset, Disease, Biology, medicine.disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, medicine, Neurology (clinical), Geriatrics and Gerontology, Presentation (obstetrics), Frontotemporal dementia
Published
2020

10. Subtype and stage inference identifies distinct atrophy patterns in genetic frontotemporal dementia that MAP onto specific MAPT mutations

Author

Sandro Sorbi, James B. Rowe, Matthis Synofzik, A. Danek, Martina Bocchetta, Johannes Levin, Markus Otto, Rhian S Convery, Fabrizio Tagliavini, Steven Williams, Daniel C. Alexander, Barbara Borroni, Mollie Neason, David L. Thomas, Jonathan D. Rohrer, Carmela Tartaglia, Alexandre de Mendonça, Giovanni B. Frisoni, David M. Cash, Katrina M. Moore, Roberta Ghidoni, Alexander Gerhard, Elizabeth Finger, Alexandra L. Young, Isabel Santana, Christopher C Butler, Fermin Moreno, Caroline Graff, John C. van Swieten, Mario Masellis, Raquel Sánchez-Valle, Robert Laforce, Simon Ducharme, Daniela Galimberti, and Rik Vandenberghe

Subjects
Epidemiology, Health Policy, Neurodegeneration, Inference, Biology, medicine.disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Atrophy, Developmental Neuroscience, medicine, Neurology (clinical), Geriatrics and Gerontology, Stage (cooking), Neuroscience, Frontotemporal dementia
Published
2020

11. The Free Cued Selective Reminding Test detects episodic memory impairment in the presymptomatic period of familial frontotemporal dementia within the GENFI cohort

Author

Alexandre de Mendonça, Esther van den Berg, Christopher C Butler, Fabrizio Tagliavini, Alexander Gerhard, Georgia Peakman, Janne M. Papma, Johannes Levin, James B. Rowe, Markus Otto, Katrina M. Moore, Elizabeth Finger, Jackie M. Poos, A. Danek, Simon Ducharme, Jonathan D. Rohrer, Daniela Galimberti, Carmela Tartaglia, Isabel Santana, Rik Vandenberghe, Caroline V. Greaves, Robert Laforce, Raquel Sánchez-Valle, Martina Bocchetta, Matthis Synofzik, Caroline Graff, Lize C. Jiskoot, John C. van Swieten, Mario Masellis, Lucy L. Russell, Fermin Moreno, and Barbara Borroni

Subjects
Cued speech, medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Period (gene), Neuropsychology, Audiology, medicine.disease, Test (assessment), Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Cohort, medicine, Neurology (clinical), Geriatrics and Gerontology, Cognitive decline, business, Episodic memory, Frontotemporal dementia
Published
2020

12. Trajectory of apathy, cognition and neural correlates in the decades before symptoms in frontotemporal dementia

Author

Roberta Ghidoni, Matthis Synofzik, Elizabeth Finger, Timothy Rittman, Kamen A. Tsvetanov, James B. Rowe, Caroline Graff, Georgia Peakman, Fabrizio Tagliavini, Johannes Levin, Alexandre de Mendonça, A. Danek, Giovanni B. Frisoni, Isabel Santana, Rhian S Convery, Carmela Tartaglia, Markus Otto, John C. van Swieten, Alexander Gerhard, Jonathan D. Rohrer, Simon Ducharme, P. Simon Jones, Maura Malpetti, Rogier A. Kievit, Fermin Moreno, Carolin Heller, Robert Laforce, Emily Todd, Daniela Galimberti, Raquel Sánchez-Valle, Rik Vandenberghe, Christopher C Butler, Barbara Borroni, Mario Masellis, Katrina M. Moore, and Martina Bocchetta

Subjects
Gerontology, Neural correlates of consciousness, Epidemiology, Health Policy, Cognition, medicine.disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Ageing, medicine, Dementia, Apathy, Neurology (clinical), Geriatrics and Gerontology, medicine.symptom, Association (psychology), Psychology, Frontotemporal dementia
Published
2020

13. P2‐179: STAVUDINE INHIBITS INFLAMMASOME ACTIVATION MOLECULAR INHIBITOR IN PERIPHERAL‐MONOCYTES OF AD PATIENTS

Author

Ivana Marventano, Daniela Galimberti, Mario Clerici, Francesca La Rosa, Chiara Fenoglio, Federica Piancone, and Marina Saresella

Subjects
Epidemiology, business.industry, Health Policy, Stavudine, Inflammasome, Pharmacology, Peripheral, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, medicine, Neurology (clinical), Geriatrics and Gerontology, business, medicine.drug
Published
2018

14. P1-380: EARLY REGIONAL HYPOMETABOLISM IN PRE-SYMPTOMATIC CARRIERS OF MAPT : A GENFI SUB-STUDY

Author

John C. van Swieten, David M. Cash, Jason D. Warren, Frédéric St-Onge, Barbara Borroni, Giovanni B. Frisoni, Mirza Faisal Beg, Fabrizio Tagliavini, Daniela Galimberti, Sandro Sorbi, Carmela Tartaglia, Robert Laforce, Popuri Karteek, Caroline Graff, Mario Masellis, Martina Bocchetta, Alexandre de Mendonça, Katrina M. Dick, James B. Rowe, Jean-Mathieu Beauregard, Jonathan D. Rohrer, and Elizabeth Finger

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2019

15. [IC‐P‐079]: MULTIPLE DISTINCT ATROPHY PATTERNS FOUND IN GENETIC FRONTOTEMPORAL DEMENTIA USING SUBTYPE AND STAGE INFERENCE (SUSTAIN)

Author

Robert Laforce, John C. van Swieten, Alexandre de Mendonça, Katrina M. Dick, Razvan V. Marinescu, Daniela Galimberti, Daniel C. Alexander, Fabrizio Tagliavini, Mario Masellis, Barbara Borroni, Sandro Sorbi, Neil P. Oxtoby, James B. Rowe, Maria Carmela Tartaglia, Jonathan M. Schott, Nick C. Fox, David L. Thomas, Jonathan D. Rohrer, Giovanni B. Frisoni, Elizabeth Finger, Sebastien Ourselin, Alexandra L. Young, David M. Cash, Martina Bocchetta, Caroline Graff, and M. Jorge Cardoso

Subjects
Epidemiology, Health Policy, Inference, Biology, medicine.disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Atrophy, Developmental Neuroscience, medicine, Neurology (clinical), Geriatrics and Gerontology, Stage (cooking), Neuroscience, Frontotemporal dementia
Published
2017

16. [IC‐03–04]: WHITE MATTER HYPERINTENSITIES IN GENETIC FRONTOTEMPORAL DEMENTIA: A GENFI STUDY

Author

Carole H. Sudre, Elizabeth Finger, David L. Thomas, Sebastien Ourselin, Jonathan D. Rohrer, Daniela Galimberti, Barbara Borroni, M. Jorge Cardoso, Martina Bocchetta, Robert Laforce, Fabrizio Tagliavini, Alexandre de Mendonça, Ione O.C. Woollacott, David M. Cash, Maria Carmela Tartaglia, James B. Rowe, Sandro Sorbi, Katrina M. Dick, Caroline Graff, Giovanni B. Frisoni, Mario Masellis, and John C. van Swieten

Subjects
medicine.medical_specialty, Epidemiology, Health Policy, medicine.disease, Hyperintensity, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, medicine, Neurology (clinical), Geriatrics and Gerontology, Psychiatry, Psychology, Frontotemporal dementia
Published
2017

17. [P1–029]: IN GENETIC FRONTOTEMPORAL DEMENTIA, FUNCTIONAL NETWORK EFFICIENCY IS MAINTAINED UNTIL THE ONSET OF SYMPTOMS: EVIDENCE FOR FUNCTIONAL RESILIENCE TO STRUCTURAL CHANGE

Author

Alexandre de Mendonça, Robin J Borchert, Sandro Sorbi, Jonathan D. Rohrer, James B. Rowe, P. Simon Jones, Robert Laforce, Fabrizio Tagliavini, Barbara Borroni, Elizabeth Finger, Daniela Galimberti, Giovanni B. Frisoni, Caroline Graff, Timothy Rittman, John C. van Swieten, and Mario Masellis

Subjects
Epidemiology, Health Policy, medicine.disease, Developmental psychology, Functional networks, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, medicine, Neurology (clinical), Geriatrics and Gerontology, Psychology, Resilience (network), Frontotemporal dementia
Published
2017

18. [P4–189]: SYMPTOM ONSET IN GENETIC FRONTOTEMPORAL DEMENTIA

Author

Alexandre de Mendonça, Maria Carmela Tartaglia, Edward D. Huey, Matthis Synofzik, Isabelle Le Ber, John C. van Swieten, Jennifer M. Nicholas, Johannes Levin, Ian R. A. Mackenzie, Erik D. Roberson, Robert Laforce, Florence Pasquier, Markus Otto, Philippe Couratier, Nupur Ghoshal, Sokratis G. Papageorgiou, Jonathan D. Rohrer, Mario Masellis, Caroline Graff, Raquel Sánchez-Valle, Christopher C Butler, Adam L. Boxer, Giovanni B. Frisoni, Adeline Su Lyn Ng, Katrina M. Dick, Bradley F. Boeve, Sandro Sorbi, John R. Hodges, Howard J. Rosen, Simon Ducharme, Emily Rogalski, Fabrizio Tagliavini, Barbara Borroni, Isabel Santana, Daniela Galimberti, Chiadi U. Onyike, Rik Vandenberghe, Amy Brodtmann, Elizabeth Finger, Fermin Moreno, Olivier Martinaud, Alexander Gerhard, James B. Rowe, Bradford C. Dickerson, and Murray Grossman

Subjects
Pediatrics, medicine.medical_specialty, Epidemiology, business.industry, Health Policy, 030204 cardiovascular system & hematology, medicine.disease, 03 medical and health sciences, Psychiatry and Mental health, Cellular and Molecular Neuroscience, 0302 clinical medicine, Developmental Neuroscience, medicine, Neurology (clinical), Symptom onset, Geriatrics and Gerontology, business, 030217 neurology & neurosurgery, Frontotemporal dementia
Published
2017

19. [P1–437]: PRESYMPTOMATIC WHITE MATTER INTEGRITY LOSS IN FAMILIAL FRONTOTEMPORAL DEMENTIA IN THE GENETIC FRONTOTEMPORAL DEMENTIA INITIATIVE (GENFI) COHORT: A MULTI‐CENTRE, CROSS‐SECTIONAL, DIFFUSION TENSOR IMAGING STUDY

Author

Alexandre de Mendonça, Robert Laforce, Caroline Graff, Giovanni B. Frisoni, Lize C. Jiskoot, James B. Rowe, Barbara Borroni, Fabrizio Tagliavini, Jennifer M. Nicholas, Maria Carmela Tartaglia, Daniela Galimberti, Jonathan D. Rohrer, Martina Bocchetta, John C. van Swieten, David M. Cash, Mario Masellis, Sandro Sorbi, Janne M. Papma, Elizabeth Finger, and Marc Modat

Subjects
medicine.medical_specialty, Epidemiology, business.industry, Health Policy, medicine.disease, White matter, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Physical medicine and rehabilitation, medicine.anatomical_structure, Developmental Neuroscience, Cohort, medicine, Neurology (clinical), Geriatrics and Gerontology, Multi centre, business, Diffusion MRI, Frontotemporal dementia
Published
2017

20. P2-183: ANALYSIS OF IL-33 AND ITS DECOY RECEPTOR SST2 IN ALZHEIMER'S DISEASE AND MILD COGNITIVE IMPAIRMENT PATIENTS

Author

Ivana Marventano, Mario Clerici, Federica Piancone, Chiara Fenoglio, Elio Scarpini, Francesca La Rosa, Marina Saresella, and Daniela Galimberti

Subjects
Epidemiology, business.industry, Health Policy, Disease, Interleukin 33, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Immunology, Medicine, Neurology (clinical), Geriatrics and Gerontology, Cognitive impairment, Decoy, Receptor, business
Published
2019

21. P2-182: DEFECTIVE MIRNA-223-MEDIATED REGULATION OF NLRP3 INFLAMMASOME ACTIVATION IN ALZHEIMER'S DISEASE

Author

Daniela Galimberti, Mario Clerici, Marina Saresella, Chiara Fenoglio, Elio Scarpini, Federica Piancone, Francesca La Rosa, Roberta Mancuso, Ambra Hernis, and Ivana Marventano

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, microRNA, Neurology (clinical), NLRP3 inflammasome activation, Disease, Geriatrics and Gerontology, Biology, Cell biology
Published
2019

22. O4-03-06: LONGITUDINAL ASSOCIATION BETWEEN APATHY AND COGNITIVE DECLINE IN PRE- AND POST-SYMPTOMATIC GENETIC FRONTOTEMPORAL DEMENTIA

Author

Johannes Levin, Matthis Synofzik, Rhian S Convery, Markus Otto, Alexandre de Mendonça, John C. van Swieten, Maura Malpetti, Fermin Moreno, Raquel Sánchez-Valle, Rogier A. Kievit, P. Simon Jones, Carolin Heller, Kamen A. Tsvetanov, Isabel Santana, Robert Laforce, Adrian Danek, Mario Masellis, Simon Ducharme, Elizabeth Finger, Jonathon D. Rohrer, Timothy Rittman, Christopher C Butler, Daniela Galimberti, Stefano F. Cappa, Rik Vandenberghe, Carmela Tartaglia, Fabrizio Tagliavini, James B. Rowe, Barbara Borroni, Alexander Gerhard, Katrina M. Dick, Caroline Graff, and Giovanni B. Frisoni

Subjects
medicine.medical_specialty, Epidemiology, business.industry, Health Policy, medicine.disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, medicine, Apathy, Neurology (clinical), Geriatrics and Gerontology, Cognitive decline, medicine.symptom, Psychiatry, business, Association (psychology), Pre and post, Frontotemporal dementia
Published
2019

23. S4‐01‐01: Cross‐Sectional Studies of Plasma Proteomic Biomarkers Relating to Pet Amyloid and CSF Amyloid and Tau

Author

Charlotte E. Teunissen, Daniela Galimberti, Abdul Hye, Alison L. Baird, Sarah Westwood, Cristina Tan Hehir, Keyur Desai, Benjamine Young Liu, Chantal Bazenet, Malcolm Ward, Steven J. Kiddle, David Baker, Ben Newton, John Frederick Graf, Simon Lovestone, Lucilla Parnetti, Nicholas J. Ashton, Alberto Lleó, Madhav Thambisetty, and Philip Scheltens

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Pathology, medicine.medical_specialty, Developmental Neuroscience, Amyloid, Epidemiology, business.industry, Health Policy, medicine, Neurology (clinical), Geriatrics and Gerontology, business
Published
2016

24. O5‐05‐03: Novel CSF Biomarkers Discriminating FTLD‐TDP from Non‐Demented Controls

Author

William T. Hu, Naura Elias, Charlotte E. Teunissen, Marleen J.A. Koel-Simmelink, Daniela Galimberti, Marta Del Campo, and Lynn Boonkamp

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Pathology, medicine.medical_specialty, Developmental Neuroscience, Epidemiology, Health Policy, Ftld tdp, Csf biomarkers, medicine, Neurology (clinical), Geriatrics and Gerontology
Published
2016

25. P1‐025: Cerebral Perfusion as an Imaging Biomarker of Presymptomatic Genetic Frontotemporal Dementia: Preliminary Results from the Genetic Frontotemporal Dementia Initiative (GENFI)

Author

Maria Carmela Tartaglia, Pietro Tiraboschi, Vesna Jelic, Christin Andersson, Miklos Espak, Håkan Thonberg, Ian Coyle-Gilchrist, Giorgio G. Fumagalli, Elise G.P. Dopper, Rosa Rademakers, Jennifer M. Nicholas, Christen Shoesmith, Joanne Knight, Enrico De Vita, Serge A.R.B. Rombouts, Caroline Graff, Daniela Galimberti, Ekaterina Rogaeva, Jason D. Warren, David M. Cash, Rick van Minkelen, Morris Freedman, Bradley J. MacIntosh, M. Jorge Cardoso, David F. Tang-Wai, Lena Lilius, Martina Bocchetta, Veronica Redaelli, Marina Grisoli, Fabrizio Tagliavini, Sara Prioni, Ron Keren, Martin N. Rossor, Marie Fallström, Elio Scarpini, Henri J.M.M. Mutsaerts, Linn Öijerstedt, Lize C. Jiskoot, James B. Rowe, Elizabeth Finger, Sebastien Ourselin, Andrea Arighi, Katrina M. Dick, Nick C. Fox, David L. Thomas, Jonathan D. Rohrer, Simon Mead, Robert Laforce, Sandra E. Black, Mario Masellis, and John C. van Swieten

Subjects
medicine.medical_specialty, Pathology, Neurology, Imaging biomarker, Epidemiology, Health Policy, Putamen, Caudate nucleus, Grey matter, medicine.disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, medicine.anatomical_structure, Developmental Neuroscience, Cerebral blood flow, Internal medicine, mental disorders, medicine, Cardiology, Biomarker (medicine), Neurology (clinical), Geriatrics and Gerontology, Psychology, Frontotemporal dementia
Abstract

Background Frontotemporal dementia (FTD) is a common cause of early onset dementia. While three genetic mutations are responsible for the majority of genetic FTD, imaging biomarkers that predict symptom onset are needed1. Recent work shows volumetric changes several years before the predicted age at disease onset2. Herein, we extend on this work by investigating whether perfusion patterns derived from non-invasive arterial spin labeling (ASL) MRI can be used as an early functional neuroimaging biomarker of presymptomatic genetic FTD. Methods Data were drawn from the GENetic Frontotemporal dementia Initiative (GENFI)2. From the first GENFI data freeze (n=220), 168 subjects had 3T ASL from which this analysis considers only the presymptomatic carriers and controls (n=144, Table 1). Cerebral blood flow (CBF)-maps were scaled to a mean grey matter (GM) CBF of 50 mL/100g/min per ASL sequence (four different ASL sequences were used) and registered to SPM12 3D T1 GM segmentations that were registered to MNI using DARTEL. In pre-selected ROIs associated with FTD, we investigated the effects of mutation status and years to expected age of disease onset on CBF, accounting for gender and family membership as fixed and random covariates. ROI CBF-values were corrected for partial volume fractions. Results Years to expected age of disease onset (p 0.1), there was an interaction effect between mutation carrier status and years to expected age of disease onset on CBF (Table 2). This interaction effect was significant for all ROIs except for the parietal and occipital cortices, anterior cingulate and putamen with the strongest effects being seen in the insula and the caudate nucleus (Figure 1). Conclusions CBF decreased as individuals approached the expected age of disease onset and this CBF decrease was accelerated in the presymptomatic mutation carriers compared to controls, in key regions implicated in FTD. These preliminary findings demonstrate the potential utility of non-invasive perfusion MRI as an early biomarker for genetic FTD. References 1. Montine et al., Neurology 2014 2. Rohrer et al., Lancet Neurol 2015

Published
2016

26. IC‐P‐054: Grey matter differences in genetic frontotemporal dementia: Results from the genfi study

Author

Giovanni B. Frisoni, Martin N. Rossor, James B. Rowe, Caroline Graff, Mario Masellis, Miklos Espak, Alexander D. Fellows, David M. Cash, Sandro Sorbi, Katrina M. Dick, Barbara Borroni, John C. van Swieten, Daniela Galimberti, Robert Laforce, Alexandre de Mendonça, Fabrizio Tagliavini, Jonathan D. Rohrer, Elizabeth Finger, and Sebastien Ourselin

Subjects
Epidemiology, Health Policy, Grey matter, medicine.disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, medicine.anatomical_structure, Developmental Neuroscience, medicine, Neurology (clinical), Geriatrics and Gerontology, Psychology, Clinical psychology, Frontotemporal dementia
Published
2015

27. F2‐03‐04: Genetic risk factors for posterior cortical atrophy

Author

Yolande A.L. Pijnenburg, Julie S. Snowden, Eulogio Gil-Néciga, Timothy J. Shakespeare, Aida Suarez Gonzalez, John Hardy, Bruno Dubois, John R. Hodges, Dennis W. Dickson, Douglas Galasko, Nick C. Fox, Stuart Pickering-Brown, Marie Sarazin, Stefano F. Cappa, Eva Louwersheimer, Glenda M. Halliday, Minerva M. Carrasquillo, David S. Knopman, Natalie S. Ryan, Sebastian J. Crutch, Jonathan M. Schott, Jenny Harris, Bradley F. Boeve, Nilufer Taner, Eloi Magnin, Martin N. Rossor, Gil D. Rabinovici, Lauren Bartley, Neil Graff-Radford, Melissa E. Murray, John Collinge, James Uphill, Ronald C. Petersen, Jose Bras, Manja Lehmann, Simon Mead, Philip Scheltens, Daniela Galimberti, Khan Qurat ul Ain, Wiesje M. van der Flier, and Elio Scarpini

Subjects
Pathology, medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Posterior cortical atrophy, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, medicine, Neurology (clinical), Geriatrics and Gerontology, Genetic risk, business
Published
2015

28. O2‐01‐01: Grey matter differences in genetic frontotemporal dementia: Results from the genfi study

Author

James B. Rowe, Sandro Sorbi, Elizabeth Finger, Martin N. Rossor, Alexandre de Mendonça, David M. Cash, Katrina M. Dick, John C. van Swieten, Robert Laforce, Mario Masellis, Giovanni B. Frisoni, Sebastien Ourselin, Miklos Espak, Daniela Galimberti, Alexander D. Fellows, Caroline Graff, Barbara Borroni, Jonathan D. Rohrer, and Fabrizio Tagliavini

Subjects
Pediatrics, medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Disease, medicine.disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Neuroimaging, medicine, Neurology (clinical), Geriatrics and Gerontology, business, Frontotemporal dementia
Published
2015

29. P4‐009: Frontotemporal dementia and parkinsonism linked to chromosome 17 granulin: Clinical and pathologic study of a patient from a new pedigree

Author

Adrian L. Oblak, Federico Rodriguez-Porcel, Bernardino Ghetti, Marwah M. Abdulkader, Albert Espay, Matthew C. Hagen, Chiara Fenoglio, Jill R. Murrell, Sara M G Cioffi, Daniela Galimberti, and Elio Scarpini

Subjects
Pathology, medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Granulin, medicine.disease, Frontotemporal dementia and parkinsonism linked to chromosome 17, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Medicine, Neurology (clinical), Geriatrics and Gerontology, business
Published
2015

30. P1‐115: Consensus guidelines to perform lumbar puncture for CSF sampling in patients with neurological conditions

Author

Gerwin Roks, José-Luis Molinuevo, Bernhard Hemmer, Hanne Struyfs, Sharmilee Gnanapavan, Alberto Lleó, Henrik Zetterberg, Jakub Hort, Guy Nagels, Martin Ingelsson, Manuel Comabella, Jens Kuhle, Michael Jonsson, Flora H. Duits, Anders Wall, Alexandre de Mendonça, Bengt Winblad, Charlotte E. Teunissen, Daniela Galimberti, Wiesje M. van der Flier, Ellis Niemantsverdriet, Sebastiaan Engelborghs, Philip Scheltens, Lucilla Parnetti, Kaj Blennow, Constance Skarsgard, Ellen Iacobaeus, Irena Dujmovic, Erik Stomrud, Hayrettin Tumani, Frank Jan de Jong, Michael Khalil, Pieter Jelle Visser, Erik Hoff, Claire Paquet, and Raf Brouns

Subjects
medicine.medical_specialty, medicine.diagnostic_test, Epidemiology, Lumbar puncture, business.industry, Health Policy, Surgery, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Anesthesia, medicine, In patient, Sampling (medicine), Neurology (clinical), Geriatrics and Gerontology, business
Published
2015

31. P1‐044: TREM2 GENETIC VARIABILITY IN PATIENTS WITH ALZHEIMER'S DISEASE AND FRONTOTEMPORAL LOBAR DEGENERATION

Author

Claudio Mariani, Giulia Grande, Laura Ghezzi, Laura Maggiore, Francesca Clerici, Chiara Fenoglio, Maria Serpente, Sara M G Cioffi, Daniela Galimberti, Andrea Arighi, and Elio Scarpini

Subjects
Pathology, medicine.medical_specialty, Epidemiology, TREM2, business.industry, Health Policy, Multiple sclerosis, Central nervous system, Frontotemporal lobar degeneration, Disease, medicine.disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Real-time polymerase chain reaction, medicine.anatomical_structure, Cerebrospinal fluid, Developmental Neuroscience, Cohort, medicine, Neurology (clinical), Geriatrics and Gerontology, business
Abstract

Background: Circulating micro (mi) RNAs have been reported as promising biomarkers with great accuracy for neurodegenerative disorders and processes affecting the central nervous system, particularly in aging, Parkinson’s disease and Multiple Sclerosis. Aim of this study is to identify specific circulating miRNAs in serum as possible biomarkers for Alzheimer’s disease (AD). Methods: A specific PCR array containing 84 common miRNAs was used to screen miRNA serum levels in 7 patients with AD and 6 Non-Inflammatory Neurological Controls (NINDCs). Best hits were first validated by real time PCR in an independent cohort consisting of 15 serum samples fromADpatients and 12NINDCs, comparing them also to 10 subjects affected by frontotemporal lobar degeneration (FTLD) and 8 Inflammatory Neurological Controls (INDCs). Finally, the same analysis was conducted also in samples of cerebrospinal fluid (CSF). Results: Statistically significant decreased levels of miR-125b, miR-223, miR-23a and miR-26b were observed in AD patients compared to NINDCs (-5.5, -4.5, -5.0 and -6.3 fold regulation over NINDCs respectively, p

Published
2014

32. P1‐043: CIRCULATING AND INTRATHECAL MIRNAS AS POTENTIAL BIOMARKERS FOR ALZHEIMER'S DISEASE

Author

Sara M G Cioffi, Rossana Bonsi, Carlotta Donelli, Antonio Callea, Andrea Arighi, Chiara Fenoglio, Laura Ghezzi, Maria Serpente, Daniela Galimberti, Paola Basilico, and Elio Scarpini

Subjects
Epidemiology, business.industry, Health Policy, Disease, Intrathecal, Bioinformatics, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Potential biomarkers, microRNA, Medicine, Neurology (clinical), Geriatrics and Gerontology, business
Published
2014

33. P4‐074: ITALIAN NETWORK FOR AUTOSOMAL DOMINANT ALZHEIMER'S DISEASE AND FRONTOTEMPORAL LOBAR DEGENERATION (ITALIANDIAFN)

Author

Alessandro Padovani, Giuseppe Di Fede, Elio Scarpini, Martina Bocchetta, Emilio Di Maria, Giacomina Rossi, Silvia Suardi, Giuliano Binetti, Massimo Gennarelli, Daniela Galimberti, Livia Bernardi, Fabrizio Vecchio, Barbara Borroni, Benedetta Nacmias, Luisa Benussi, Anna Mega, Claudio Babiloni, Fabrizio Tagliavini, Amalia C. Bruni, Irene Piaceri, Corinna Porteri, Michela Pievani, Giovanni B. Frisoni, Roberta Ghidoni, Sandro Sorbi, Nicola Marzano, and Silvia Fostinelli

Subjects
Epidemiology, Health Policy, media_common.quotation_subject, Frontotemporal lobar degeneration, Art, medicine.disease, Associative learning, Right frontal lobe, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, medicine, Neurology (clinical), Geriatrics and Gerontology, Right hemisphere, Humanities, media_common
Abstract

Diffusion datasets were corrected for motion and eddy current distortions (Smith et al., 2004) and then processed with a Spherical Deconvolution algorithm based on a damped version of the Richardson-Lucy algorithm (Dell’acqua et al., 2010, Dell’Acqua et al., 2013). Tractography was performed following the method described in (Catani et al., 2012). We dissected fiftyfive frontal tracts including U-shaped fibers. For each dissection FA (Basser and Pierpaoli, 1996) and hindrance modulated oriented anisotropy (HMOA) (Dell’Acqua et al., 2013) were extracted as an indirect measure of the tract integrity and correlated with the age of the participants regressing out the level of education. P values are presented after false discovery rate (FDR) correction for multiple comparisons (* p < 0.05 ; ** p < 0.01 ; *** p < 0.001). Results: Aging was significantly associated with a decrease of FA (r1⁄4 0.501*) and OA (r1⁄4 0.508**) in the frontal projections of the corpus callosum. Aging was also associated with a decrease of OA in the right frontal lobe including the SLF I (r 1⁄4 0.401**) and SLF III (r 1⁄4 0.576***) branches of the superior longitudinal fasciculus, inferior fronto-occipital fasciculus (r 1⁄4 0.331*), fronto-thalamic projections (r 1⁄4 0.515***). In the left hemisphere, OA measure also decreased with aging for the frontal inferior longitudinal fasciculus (r1⁄4 0.542***) and the frontal orbito-polar tract (r 1⁄4 0.542***). Results are summarized in Figure 1. Conclusions: We confirmed preliminary evidences reporting reduced integrity in the frontal portion of the corpus callosum associated with aging (Lebel et al., 2010). This commissural decline may explain the increased reaction times associated with aging reported in tasks requiring interhemispheric transfer (Reuter-Lorenz and Stanczak, 2000). Our results also suggest for the first time that aging alters significantly other tracts in the right hemisphere which brings up interesting pathophysiological hypotheses for ageing decline in visuospatial and verbal working memory, memory encoding and retrieval, reward-based associative learning that can be tested in the elderly (Cabeza and Dennis, 2012). IC-P-069 ITALIAN NETWORK FOR AUTOSOMAL DOMINANTALZHEIMER’S DISEASE AND FRONTOTEMPORAL LOBAR DEGENERATION (ITALIANDIAFN) Martina Bocchetta, Michela Pievani, Claudio Babiloni, Amalia C. Bruni, Elio Scarpini, Sandro Sorbi, Fabrizio Tagliavini, Alessandro Padovani, Luisa Benussi, Livia Bernardi, Giuliano Binetti, Barbara Borroni, Giuseppe Di Fede, Emilio Di Maria, Silvia Fostinelli, Daniela Galimberti, Massimo Gennarelli, Roberta Ghidoni, Nicola Marzano, Anna Mega, Benedetta Nacmias, Irene Piaceri, Corinna Porteri, Giacomina Rossi, Silvia Suardi, Fabrizio Vecchio, Giovanni B. Frisoni, IRCCS Centro S. Giovanni di Dio, Fatebenefratelli, Brescia, Italy; IRCCS Fatebenefratelli, Brescia, Italy; 3 University of Rome "La Sapienza", Rome, Italy; 4 Centro Regionale di Neurogenetica, Lamezia Terme (CZ), Italy; 5 Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy; University of Florence, Florence, Italy; IRCCS Foundation "Carlo Besta" Neurological Institute, Milano, Italy; 8 University of Brescia, Brescia, Italy; 9 IRCCS Instituto Centro S. Giovanni di Dio Fatebenefratelli, Brescia, Italy; 10 Centro Regionale di Neurogenetica, Lamezia Terme, Italy; IRCCS Foundation "Carlo Besta" Neurological Institute, Milan, Italy; University of Genova, Genova, Italy; 13 IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy; University of Milan, Ospedale Policlinico, Milan, Italy; IRCCS Centro San Giovanni di Dio, Fatebenefratelli, Brescia, Italy; 16 University of Florence, Florence, Italy; 17 IRCCS Fondazione Instituto Neurologico Carlo Besta, Milano, Italy; 18 IRCCS Fondazione Instituto Neurologico Carlo Besta, Milan, Italy; IRCCS Instituto San Giovanni di Dio Fatebenefratelli, Brecia, Italy. Contact e-mail: mbocchetta@ fatebenefratelli.it

Published
2014

34. IC‐P‐069: ITALIAN NETWORK FOR AUTOSOMAL DOMINANT ALZHEIMER'S DISEASE AND FRONTOTEMPORAL LOBAR DEGENERATION (ITALIANDIAFN)

Author

Martina Bocchetta, Michela Pievani, Claudio Babiloni, Amalia C. Bruni, Elio Scarpini, Sandro Sorbi, Fabrizio Tagliavini, Alessandro Padovani, Luisa Benussi, Livia Bernardi, Giuliano Binetti, Barbara Borroni, Giuseppe Di Fede, Emilio Di Maria, Silvia Fostinelli, Daniela Galimberti, Massimo Gennarelli, Roberta Ghidoni, Nicola Marzano, Anna Mega, Benedetta Nacmias, Irene Piaceri, Corinna Porteri, Giacomina Rossi, Silvia Suardi, Fabrizio Vecchio, and Giovanni B. Frisoni

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2014

35. P3‐104: A NOVEL MUTATION IN PROGRANULIN GENE IN BEHAVIOURAL VARIANT FRONTO‐TEMPORAL DEMENTIA

Author

Simona Gardini, Caterina Ghetti, Anna M. Pietroboni, Federica Barocco, Alberto Calvi, Paolo Caffarra, Elio Scarpini, Letizia Concari, Marco Spallazzi, Livia Ruffini, Sara M G Cioffi, Daniela Galimberti, and Chiara Fenoglio

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Fronto temporal dementia, Geriatrics and Gerontology, Biology, Gene, Novel mutation, Neuroscience
Published
2014

36. P1‐231: Role of OLR1 and Its Regulating hsa‐miR369‐3p in Alzheimer's Disease: Genetic and Expression Analysis

Author

Daniela Galimberti, Francesca Clerici, Giuliano Binetti, Chiara Villa, Elio Scarpini, Alessandra Marcone, Nereo Bresolin, Maria Teresa Giordana, Roberta Ghidoni, Claudio Mariani, Massimo Franceschi, Stefano F. Cappa, Innocenzo Rainero, Francesca Cortini, Maria Serpente, Salvatore Gallone, Chiara Fenoglio, Claudia Cantoni, Elisa Ridolfi, and Luisa Benussi

Subjects
Genetics, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Expression analysis, OLR1, Neurology (clinical), Disease, Geriatrics and Gerontology, Biology
Published
2011

37. P1‐282: Annamaria Confaloni PhD

Author

Giuseppina Talarico, Daniela Galimberti, Angelo Toto, Chiara Belli, Annamaria Confaloni, Saviana Barbati, Elio Scarpini, Anna Poleggi, Marina Gasparini, Paola Piscopo, Giuseppe Bruno, and Alessio Crestini

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2011

38. P1‐286: A novel MAPT mutation associated with the clinical phenotype of progressive nonfluent aphasia

Author

Elisa Ridolfi, Luisa Benussi, Andrea Arighi, Elio Scarpini, Alessandra Marcone, A. Mandelli, Chiara Fenoglio, Maria Serpente, Francesca Cortini, Stefano F. Cappa, Giuliano Binetti, Anna M. Pietroboni, Nereo Bresolin, Giorgio G. Fumagalli, Francesca Jacini, Chiara Villa, Roberta Ghidoni, Laura Ghezzi, Claudia Cantoni, and Daniela Galimberti

Subjects
Genetics, Epidemiology, business.industry, Health Policy, medicine.disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Progressive nonfluent aphasia, Mutation (genetic algorithm), medicine, Neurology (clinical), Geriatrics and Gerontology, Clinical phenotype, business
Published
2011

39. P1‐092: Chromosome 9 and sporadic Frontotemporal Lobar Degeneration: KIF24, but not UBAP1, is a risk factor in Italian population

Author

Salvatore Gallone, Maria Teresa Giordana, Roberta Ghidoni, Elio Scarpini, Alessandra Marcone, Nereo Bresolin, Innocenzo Rainero, Diego Scalabrini, Chiara Villa, Stefano F. Cappa, Francesca Cortini, Massimo Franceschi, Eliana Venturelli, Francesca Clerici, Giuliano Binetti, Luisa Benussi, Claudio Mariani, Daniela Galimberti, and Chiara Fenoglio

Subjects
Oncology, medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Chromosome 9, Frontotemporal lobar degeneration, medicine.disease, Italian population, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Internal medicine, Medicine, Neurology (clinical), Geriatrics and Gerontology, Risk factor, business
Published
2010

40. P4‐101: Urea cycle and Alzheimer's disease

Author

Geoffroy Laumet, Franck Hansmannel, Philippe Amouyel, Didier Hannequin, Claudine Berr, Jean-Charles Lambert, Florence Pasquier, Steven T. DeKosky, Julien Chapuis, Anne Marie Ayral, Ilyas Kamboh, David G. Mann, Jean Jacques Hauw, Dominique Campion, Elio Scarpini, Daniela Galimberti, and Corinne Lendon

Subjects
medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Endocrinology, Developmental Neuroscience, Urea cycle, Internal medicine, Medicine, Neurology (clinical), Geriatrics and Gerontology, business
Published
2009

41. P4‐107: Association study of the ADAM12 and SH3MD1 genes with the risk of developing Alzheimer's disease

Author

Geoffroy Laumet, Anne-Marie Ayral, Daniela Galimberti, Franck Hansmanel, Jean-Charles Lambert, Didier Hannequin, Philippe Amouyel, Florence Pasquier, Elio Scarpini, Corinne Lendon, Dominique Campion, Julien Chapuis, and Vincent Petitprez

Subjects
Epidemiology, business.industry, Health Policy, Association (object-oriented programming), ADAM12, Disease, Bioinformatics, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Medicine, Neurology (clinical), Geriatrics and Gerontology, business, Gene
Published
2009

42. O2‐06–06: SNPS in MAPT are associated with cerebrospinal fluid Tau levels, MAPT mRNA levels, and age at onset of late‐onset Alzheimer's disease

Author

Daniela Galimberti, Elio Scarpini, Carlos Cruchaga, Sarah Bertelsen, David M. Holtzman, Anne M. Fagan, John S. K. Kauwe, John C. Morris, Alison Goate, Aarti R. Shah, Kevin Mayo, Chiara Fenoglio, and Petra Nowotny

Subjects
medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Single-nucleotide polymorphism, Late onset, Disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Cerebrospinal fluid, Endocrinology, Developmental Neuroscience, Mrna level, Internal medicine, medicine, Neurology (clinical), Geriatrics and Gerontology, business
Published
2008

43. P1‐207: APOE alleles distribution in different forms of mild cognitive impairment

Author

Giuliana Cislaghi, Silvia Rosa, Massimo Suardelli, Claudio Mariani, Daniela Galimberti, Elio Scarpini, and Carlo Lovati

Subjects
Apolipoprotein E, Genetics, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Distribution (pharmacology), Neurology (clinical), Geriatrics and Gerontology, Allele, Biology, Cognitive impairment
Published
2008

44. P1–444: Low doses of memantine are effective in reducing behavioral symptoms in AD patients

Author

Marco Tiriticco, Daniela Galimberti, Laura Perego, Elio Scarpini, Nereo Bresolin, Barbara Corra, Andreea Dobrea, and Ilaria Guidi

Subjects
Epidemiology, business.industry, Health Policy, Low dose, Memantine, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Anesthesia, medicine, Neurology (clinical), Geriatrics and Gerontology, business, medicine.drug
Published
2006

45. P1–177: Total folate levels in Alzheimer disease and other forms of degenerative cognitive decline

Author

Silvia Rosa, Massimo Suardelli, Carlo Lovati, E. Capiluppi, Pierluigi Bertora, Enrico Mailland, Daniela Galimberti, Alessandra Vanotti, Claudio Mariani, and Simone Pomati

Subjects
Epidemiology, business.industry, Health Policy, Physiology, medicine.disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, medicine, Neurology (clinical), Geriatrics and Gerontology, Cognitive decline, Alzheimer's disease, business
Published
2006

46. P1–221: Association between dementia and cancer

Author

Barbara Corra, Andreea Dobreea, Daniela Galimberti, Ferruccio Bonino, Marco Tiriticco, Laura Perego, Elio Scarpini, Ilaria Guidi, and Nereo Bresolin

Subjects
Oncology, medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Cancer, medicine.disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Internal medicine, medicine, Dementia, Neurology (clinical), Geriatrics and Gerontology, Association (psychology), business
Published
2006

47. P3–167: Absence of mutations in TREM–2 coding region in early onset dementia

Author

Claudio Mariani, Daniela Galimberti, Carlo Lovati, Paola Panina, Laura Piccio, Pierluigi Baron, Elio Scarpini, Eliana Venturelli, Gianluigi Forloni, Nereo Bresolin, Diego Scalabrini, Cecilia Buonsanti, and Chiara Fenoglio

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, business.industry, Health Policy, Immunology, Medicine, Coding region, Neurology (clinical), Geriatrics and Gerontology, business, Early onset dementia
Published
2006

48. P1–329: Presenilin–1 mutation E318G in Italian population: Genetic screening and effect on beta amyloid metabolism in human fibroblasts

Author

Vladimiro Artuso, Elio Scarpini, Ignazio Roiter, Marzia Pesaresi, Diego Albani, Amalia C. Bruni, Massimo Franceschi, Gianluigi Forloni, Sara Batelli, Francesca Prati, Francesca Prato, and Daniela Galimberti

Subjects
Genetics, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Presenilin 1 mutation, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology, Biology, Beta-amyloid metabolism, Italian population
Published
2006

49. P2–138: Chemokine serum levels in mild cognitive impairment as Alzheimer's disease early biomarkers

Author

Daniela Galimberti, Elio Scarpini, Francesca Clerici, Chiara Fenoglio, Claudio Mariani, Diego Scalabrini, Ilaria Guidi, Nereo Bresolin, Eliana Venturelli, Barbara Corra, and Carlo Lovati

Subjects
Chemokine, biology, Epidemiology, business.industry, Health Policy, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Immunology, biology.protein, Disease early, Medicine, Neurology (clinical), Geriatrics and Gerontology, Cognitive impairment, business
Published
2006

50. P3-217: Genetic and functional analysis of progranulin gene variants in patients with Alzheimer's disease

Author

Carlo Lovati, Elisabetta Dalla Valle, Claudio Mariani, Kevin Mayo, Francesca Cortini, Daniela Galimberti, Diego Scalabrini, Eliana Venturelli, Ilaria Guidi, Chiara Fenoglio, Elio Scarpini, John S. K. Kauwe, Chiara Villa, Nereo Bresolin, and Alison Goate

Subjects
Genetics, Epidemiology, business.industry, Health Policy, Disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Medicine, In patient, Neurology (clinical), Geriatrics and Gerontology, business, Gene, Functional analysis (psychology)
Published
2008

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