1. Cardiovascular health and cognitive outcomes: Findings from a biracial population‐based study in the United States
- Author
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Dhana, Anisa, DeCarli, Charles S, Dhana, Klodian, Desai, Pankaja, Holland, Thomas M, Evans, Denis A, and Rajan, Kumar B
- Subjects
Biomedical and Clinical Sciences ,Biological Psychology ,Clinical Sciences ,Neurosciences ,Psychology ,Brain Disorders ,Neurodegenerative ,Prevention ,Vascular Cognitive Impairment/Dementia ,Alzheimer's Disease Related Dementias (ADRD) ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Acquired Cognitive Impairment ,Clinical Research ,Aging ,Cardiovascular ,Social Determinants of Health ,Alzheimer's Disease ,Behavioral and Social Science ,Cerebrovascular ,Nutrition ,Dementia ,Neurological ,Good Health and Well Being ,Aged ,Aged ,80 and over ,Female ,Humans ,Male ,Middle Aged ,Alzheimer Disease ,Black or African American ,Cardiovascular Diseases ,Chicago ,Cognitive Dysfunction ,Cohort Studies ,Risk Factors ,United States ,White ,Alzheimer's disease ,cardiovascular health ,cognition ,dementia ,epidemiology ,incidence ,MRI ,white matter hyperintensities ,Geriatrics ,Clinical sciences ,Biological psychology - Abstract
IntroductionThe aim of this study was to evaluate the association of cardiovascular health (CVH) with cognitive outcomes, including incident Alzheimer's dementia, rate of cognitive decline, and measures of brain injury and structure.MethodsThis study consisted of 1702 Black or African American and White participants living in the south side of Chicago, Illinois, and enrolled in the Chicago Health and Aging Project, a population-based cohort since 1993. CVH was based on seven risk factors, including diet, physical activity, body mass index, smoking, dyslipidemia, hypertension, and diabetes.ResultsIn a multivariable-adjusted model, CVH was associated with a lower risk of Alzheimer's dementia. The hazard ratio per 1 additional point in CVH score was 0.84 (95% CI 0.76, 0.94). CVH was also associated with a slower rate of cognitive decline and less volume (injury) in white matter hyperintensities.DiscussionPromoting CVH in communities with Black residents may lower the future risk of Alzheimer's dementia.
- Published
- 2023