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Start Over Author "Dominic M. Walsh" Journal alzheimer's & dementia
21 results on '"Dominic M. Walsh"'

1. Transcriptomic correlates of neurite degeneration due to human brain‐derived Aβ and protection by clinical anti‐Aβ antibodies

Author

Andrew M. Stern, Wen Liu, Dennis J. Selkoe, Ming Jin, and Dominic M. Walsh

Subjects
Neurite, Amyloid, biology, Epidemiology, Health Policy, Human brain, Degeneration (medical), Cell biology, Transcriptome, Psychiatry and Mental health, Cellular and Molecular Neuroscience, medicine.anatomical_structure, Developmental Neuroscience, biology.protein, medicine, Neurology (clinical), Geriatrics and Gerontology, Antibody
Published
2020
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2. Baseline characteristics from TANGO: Phase 2 study to evaluate gosuranemab (BIIB092) in patients with early Alzheimer’s disease

Author

Annie M. Racine, Melanie B Shulman, Louis Viollet, Philipp von Rosenstiel, John O'Gorman, Tracy Mirabile, Elena Ratti, Dominic M. Walsh, Raj Rajagovindan, Danielle Graham, Jessica Kong, Stephanie Jones, and Daniela Ramirez Schrempp

Subjects
medicine.medical_specialty, Epidemiology, business.industry, Health Policy, Phases of clinical research, Disease, Clinical trial, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Baseline characteristics, Internal medicine, Medicine, In patient, Neurology (clinical), Geriatrics and Gerontology, business
Published
2020
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3. P1‐106: A HEAD‐TO‐HEAD COMPARISON OF LEAD CLINICAL ANTI‐Aβ ANTIBODIES

Author

Tracy L. Young-Pearse, Wen Liu, Weeden Timothy E, Laurent Pradier, Dominic M. Walsh, David Reczek, Valentina N. Lagomarsino, Ming Jin, Dennis J. Selkoe, and Zemin Wang

Subjects
Pathology, medicine.medical_specialty, biology, Epidemiology, business.industry, Head to head, Health Policy, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, biology.protein, Medicine, Neurology (clinical), Geriatrics and Gerontology, Antibody, business, Lead (electronics)
Published
2018
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4. P1‐301: CERTAIN PLASMA N‐TERMINAL TAU FRAGMENTS ARE ELEVATED IN AD AND AD‐MCI COMPARED TO CONTROLS

Author

Robert A. Rissman, Jonathan M. Schott, Aaron P. Schultz, Doug R. Galasko, David Mengel, Reisa A. Sperling, Keith A. Johnson, Michael J. Properzi, Andy Billinton, Zhicheng Chen, Dominic M. Walsh, Ashvini Keshavan, Henrik Zetterberg, Michael S. Perkinton, Jennifer L. Percival-Alwyn, and Purvish P. Patel

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, medicine.medical_specialty, Endocrinology, Developmental Neuroscience, Terminal (electronics), Epidemiology, Chemistry, Health Policy, Internal medicine, medicine, Neurology (clinical), Geriatrics and Gerontology
Published
2018
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5. DT‐02‐03: TARGET ENGAGEMENT IN AN AD TRIAL: CRENEZUMAB LOWERS Aβ OLIGOMER LEVELS IN CSF

Author

Tobias Bittner, Verena Steffen, Christina Rabe, Dominic M. Walsh, David Mengel, Beth L. Ostaszewski, Yifan Dang, Dennis J. Selkoe, and Ting Yang

Subjects
0301 basic medicine, Epidemiology, business.industry, Health Policy, Target engagement, Pharmacology, Oligomer, 03 medical and health sciences, Psychiatry and Mental health, Cellular and Molecular Neuroscience, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, Developmental Neuroscience, chemistry, Crenezumab, Medicine, Neurology (clinical), Geriatrics and Gerontology, business, 030217 neurology & neurosurgery
Published
2018
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6. The aqueous phase of Alzheimer's disease brain contains assemblies built from ∼4 and ∼7 kDa Aβ species

Author

Tiernan T. O'Malley, William M. Wittbold, Jessica M. Mc Donald, Gunnar Brinkmalm, Dominic M. Walsh, Alexandra J. Mably, Matthew P. Frosch, Erik Portelius, and Wen Liu

Subjects
Male, Epidemiology, Immunoprecipitation, Blotting, Western, Enzyme-Linked Immunosorbent Assay, Article, Mass Spectrometry, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Developmental Neuroscience, Alzheimer Disease, medicine, Humans, Denaturation (biochemistry), Aged, Aged, 80 and over, Amyloid beta-Peptides, biology, Health Policy, Aqueous two-phase system, Water, Human brain, Middle Aged, medicine.disease, Temporal Lobe, Frontal Lobe, Molecular Weight, Psychiatry and Mental health, Chaotropic agent, Monomer, medicine.anatomical_structure, chemistry, Biochemistry, biology.protein, Electrophoresis, Polyacrylamide Gel, Female, Neurology (clinical), Protein Multimerization, Geriatrics and Gerontology, Antibody, Alzheimer's disease
Abstract

Introduction Much knowledge about amyloid β (Aβ) aggregation and toxicity has been acquired using synthetic peptides and mouse models, whereas less is known about soluble Aβ in human brain. Methods We analyzed aqueous extracts from multiple AD brains using an array of techniques. Results Brains can contain at least four different Aβ assembly forms including: (i) monomers, (ii) a ∼7kDa Aβ species, and larger species (iii) from ∼30-150 kDa, and (iv) >160 kDa. High molecular weight species are by far the most prevalent and appear to be built from ∼7 kDa Aβ species. The ∼7 kDa Aβ species resist denaturation by chaotropic agents and have a higher Aβ42/Aβ40 ratio than monomers, and are unreactive with antibodies to Asp1 of Ab or APP residues N-terminal of Asp1. Discussion Further analysis of brain-derived ∼7 kDa Aβ species, the mechanism by which they assemble and the structures they form should reveal therapeutic and diagnostic opportunities.

Published
2015
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7. [P3–036]: MEDI1814, A HIGH‐AFFINITY ANTIBODY DIRECTED TO THE C‐TERMINUS OF AβX‐42, ABROGATES SYNAPTIC PLASTICITY DISRUPTION CAUSED BY SYNTHETIC OR AD BRAIN‐DERIVED Aβ SOLUBLE ASSEMBLIES IN VIVO

Author

Tomas Ondrejcak, Andy Billinton, Dominic M. Walsh, Maria Groves, Michael S. Perkinton, Tiernan T. O'Malley, Iain P. Chessell, Michael J. Rowan, and Amanda Dudley

Subjects
biology, Epidemiology, Chemistry, Health Policy, C-terminus, Cell biology, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Biochemistry, In vivo, Synaptic plasticity, biology.protein, Neurology (clinical), Geriatrics and Gerontology, Antibody
Published
2017
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8. P4‐058: A Novel Paradigm for the Identification and Targeting of Bioactive Abeta Species from Alzheimer Brain

Author

Wen Liu, Dennis J. Selkoe, Ming Jin, Justin D. Boyd, Matthew P. Frosch, Tiernan T. O'Malley, and Dominic M. Walsh

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Identification (biology), Neurology (clinical), Computational biology, Geriatrics and Gerontology, Biology
Published
2016
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10. P4‐264: ARE ANTI‐ABETA AGGREGATE‐PREFERRING ANTIBODIES THE FUTURE FOR AD IMMUNOTHERAPY?

Author

Brian O'Nuallain, Cynthia A. Lemere, Veronika Blinder, Charles R. Vanderburgh, Daniel Kanmert, Dominic M. Walsh, Alexandra Mably, Jeffrey Frost, and Tiernan T. O'Malley

Subjects
Aggregate (composite), biology, Epidemiology, Chemistry, Health Policy, medicine.medical_treatment, Immunotherapy, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Immunology, medicine, biology.protein, Neurology (clinical), Geriatrics and Gerontology, Antibody
Published
2014
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11. P4‐034: Alzheimer's disease human brain beta‐amyloid‐containing extracts inhibit hippocampal long‐term potentiation in rats in vivo : Relationship between soluble and insoluble preparations

Author

Neng-Wei Hu, Aedín M. Minogue, Igor Klyubin, Michael Farrell, Alexandra Mably, Dominic M. Walsh, and Michael J. Rowan

Subjects
Amyloid, Epidemiology, Chemistry, Health Policy, Long-term potentiation, Human brain, Disease, Hippocampal formation, Pharmacology, Psychiatry and Mental health, Cellular and Molecular Neuroscience, medicine.anatomical_structure, Developmental Neuroscience, In vivo, medicine, Neurology (clinical), Geriatrics and Gerontology, Beta (finance)
Published
2012
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12. P1‐238: Soluble Aβ from PSAPP mice is different to that extracted from Alzheimer patients

Author

Warren D. Hirst, Elie Needle, Roland G.W. Staal, Robert Crozier, Nathalie Breysse, Reka Nagy, Amy Sung, Michael Monaghan, David R. Riddell, Jeannie Chin, Dominic M. Walsh, Menelas N. Pangalos, Peter H. Reinhart, and J.S. Jacobsen

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2010
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13. P2‐461: Selective modulation of gamma‐secretase cleavage of the amyloid precursor family of proteins

Author

Carlo Sala Frigerio, Michael S. Wolfe, Pamela Osenkowski, Todd E. Golde, Dominic M. Walsh, Thomas Kukar, and Paul C. Engel

Subjects
biology, Epidemiology, Chemistry, Health Policy, P3 peptide, Cleavage (embryo), Selective modulation, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Biochemistry, biology.protein, Amyloid precursor protein, Neurology (clinical), Geriatrics and Gerontology, Amyloid precursor protein secretase, Gamma secretase
Published
2008
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14. P3‐415: The presence of Abeta dimers in soluble brain extract is associated with dementia

Author

George M. Savva, Carol Brayne, Dennis J. Selkoe, Ganesh M. Shankar, Fiona E. Mattews, Alfred T. Welzel, Jessica M. McDonald, Paul G. Ince, and Dominic M. Walsh

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Chemistry, Health Policy, medicine, Dementia, Neurology (clinical), Geriatrics and Gerontology, Pharmacology, medicine.disease
Published
2008
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15. P2‐338: Substrate‐targeting gamma‐secretase modulators

Author

Barbara A. Cottrell, Brenda D. Moore, Edward H. Koo, Michael S. Wolfe, Vijayaraghavan Rangachari, Wenjuan Ye, Ghulam M. Maharvi, Terrone L. Rosenberry, Thomas B. Ladd, Thomas Kukar, Boris Schmidt, Abdul H. Fauq, Patrick C. Fraering, Dominic M. Walsh, Todd E. Golde, Sarah A. Sagi, Maralyssa Bann, Alfred T. Welzel, and Justin W. Torpey

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Chemistry, Health Policy, Biophysics, Substrate (chemistry), Neurology (clinical), Geriatrics and Gerontology, Gamma secretase
Published
2008
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17. O2‐02–02: Soluble amyloid β‐protein dimers isolated directly from Alzheimer's disease patients potently impair synaptic plasticity and memory

Author

Nina E. Shepardson, Tapan Mehta, Ciaran M. Regan, Dennis J. Selkoe, Imelda M. Smith, Amaya Garcia-Munoz, Michael J. Rowan, Francesca Brett, Dominic M. Walsh, Bernardo L. Sabatini, Shaomin Li, Michael A. Farrell, Ganesh M. Shankar, and Cynthia A. Lemere

Subjects
Amyloid β, Epidemiology, Chemistry, Health Policy, Long-term potentiation, Disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Synaptic fatigue, Developmental Neuroscience, Synaptic plasticity, Neurology (clinical), Geriatrics and Gerontology, Neuroscience
Published
2008
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18. P2‐422: Co‐polymeric nanoparticles inhibit Abeta fibrillogenesis

Author

Sara Linse, Iseult Lynch, Kenneth A. Dawson, Dominic M. Walsh, Celia Cabaleiro-Lago, Aedín M. Minogue, and Fiona Quinlan-Pluck

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Chemistry, Health Policy, Biophysics, Fibrillogenesis, Neurology (clinical), Geriatrics and Gerontology, Polymeric nanoparticles
Published
2008
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20. P1–391: Monomeric Aβ peptides bearing the Flemish A21G mutation are less readily degraded by neprilysin than wild type Aβ

Author

Dominic M. Walsh, Dennis J. Selkoe, Malcolm A. Leissring, and Vicki Betts

Subjects
Epidemiology, Health Policy, Wild type, Biology, Psychiatry and Mental health, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Monomer, Developmental Neuroscience, chemistry, Biochemistry, Mutation (genetic algorithm), Neurology (clinical), Geriatrics and Gerontology, Neprilysin
Published
2006
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21. S1–02–04: Role of AB oligomers in AD

Author

Dennis J. Selkoe, Matthew Townsend, Dominic M. Walsh, Tapan Mehta, Marcia B. Podlisny, and Ganesh M. Shankar

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2006
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