1. Inflammatory markers and the risk of dementia and Alzheimer's disease: A meta-analysis
- Author
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Frank J. Wolters, Albert Hofman, Frank de Wolf, Sirwan K.L. Darweesh, Daniel Bos, M. Arfan Ikram, Epidemiology, Neurology, and Radiology & Nuclear Medicine
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Oncology ,medicine.medical_specialty ,Epidemiology ,Population ,Disease ,030204 cardiovascular system & hematology ,Cochrane Library ,Fibrinogen ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,0302 clinical medicine ,Developmental Neuroscience ,Internal medicine ,Medicine ,Dementia ,Humans ,education ,Inflammation ,education.field_of_study ,business.industry ,Health Policy ,Hazard ratio ,medicine.disease ,Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3] ,Confidence interval ,Psychiatry and Mental health ,Meta-analysis ,Neurology (clinical) ,Geriatrics and Gerontology ,business ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Item does not contain fulltext INTRODUCTION: Inflammatory markers are often elevated in patients with dementia, including Alzheimer's disease (AD). However, it remains unclear whether inflammatory markers are associated with the risk of developing dementia. METHODS: We searched PubMed, Embase, and Cochrane library for prospective population-based studies reporting associations between inflammatory markers and all-cause dementia or AD. We used random effects meta-analyses to obtain pooled hazard ratios (HRs) and 95% confidence intervals of inflammatory markers (highest vs. lowest quantile) for all-cause dementia and AD. RESULTS: Fifteen articles from 13 studies in six countries reported data that could be meta-analyzed. C-reactive protein (HR = 1.37 [1.05; 1.78]), interleukin-6 (HR = 1.40 [1.13; 1.73]), alpha1-antichymotrypsin (HR = 1.54 [1.14; 2.80]), lipoprotein-associated phospholipase A2 activity (HR = 1.40 [1.03; 1.90]), and fibrinogen were each associated with all-cause dementia, but neither was significantly associated with AD. DISCUSSION: Several inflammatory markers are associated with an increased risk of all-cause dementia; however, these markers are not specific for AD. Whether inflammatory markers closely involved in AD pathology are associated with the risk of AD remains to be elucidated.
- Published
- 2018
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