10 results on '"Kenneth S. Kosik"'
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2. Effect of APOE4 on Plasma Phospho‐tau 217 and Neurofilament Light in the PSEN1 E280A Autosomal Dominant Alzheimer’s Disease Colombian Kindred
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Jeremy J. Pruzin, Yi Su, Yinghua Chen, Kewei Chen, Hugo Lopez, Juliana Acosta‐Uribe, Diana Alzate, David Aguillon, Gloria Garcia, Jennifer Craig‐Mueller, Geidy E Serrano, Jessica B. Langbaum, Silvia Ríos‐Romenets, Yakeel T. Quiroz, Jeffrey L. Dage, Oskar Hansson, Kaj Blennow, Henrik Zetterberg, Kenneth S. Kosik, Francisco Lopera, Pierre N. Tariot, and Eric M. Reiman
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Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Epidemiology ,Health Policy ,Neurology (clinical) ,Geriatrics and Gerontology - Published
- 2022
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3. APOE ε4 and global cognitive functioning in individuals with autosomal dominant Alzheimer’s disease due to the PSEN1 E280A variant
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Daniel Vasquez, David Aguillon, Yinghua Chen, Yi Su, Juan Felipe Quintero, Natalia Acosta‐Baena, Juliana Acosta‐Uribe, Ana Y. Baena, Gloria Garcia, Claudia F Guzman, Margarita Giraldo‐Chica, Victoria Tirado, Claudia Muñoz, Silvia Ríos‐Romenets, Gabriel Oliveira, Stephanie Langella, Hyun‐Sik Yang, Clara Vila‐Castelar, Jeremy J. Pruzin, Valentina Ghisays, Pierre N. Tariot, Joseph F Arboleda‐Velasquez, Kenneth S. Kosik, Eric M. Reiman, Francisco Lopera, and Yakeel T. Quiroz
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Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Epidemiology ,Health Policy ,Neurology (clinical) ,Geriatrics and Gerontology - Published
- 2022
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4. APOE3 Christchurch mutation carriers from the Colombian kindred with autosomal dominant Alzheimer’s disease due to PSEN1 E280A
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David Aguillon, Francisco Lopera, Daniel Vasquez, Ana Y. Baena, Liliana Hincapie, Yesica Zuluaga‐Castaño, Clara Vila‐Castelar, Liliana A. Ramirez‐Gomez, Paula Aduen, Juliana Acosta‐Uribe, Kenneth S. Kosik, Eric M. Reiman, Joseph F Arboleda‐Velasquez, and Yakeel T. Quiroz
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Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Epidemiology ,Health Policy ,Neurology (clinical) ,Geriatrics and Gerontology - Published
- 2022
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5. Dementia in Latin America: Paving the way toward a regional action plan
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Raffaele Ferrari, Oscar L. Lopez, Leonel T. Takada, José Alberto Avila-Funes, Katherine L. Possin, Marcio Luiz Figueredo Balthazar, Carlos Cano-Gutierrez, Fábio Henrique de Gobbi Porto, David Orozco, Letícia Lessa Mansur, Jeronimo Martin Ramirez, André Luiz Rodrigues Palmeira, Adolfo M. García, Juan de Jesús Llibre, Henry Engler, Elisa de Paula França Resende, Silvia Kochen, Sebastian Moguilner, Lingani Mbakile-Mahlanza, Renata Kochhann, Antônio Lúcio Teixeira, Dominic Trépel, Maritza Pintado Caipa, Patricia Cogram, Yakeel T. Quiroz, Agustín Ibáñez, Ronnielly Melo Tavares, Maira Tonidandel Barbosa, Andrea Slachevsky, Roberta Diehl Rodriguez, Gonzalo A. Farías, Laís Fajersztajn, Bárbara Costa Beber, Maira Okada de Oliveira, Norberto Anizio Ferreira Frota, David Lira, Patricio Fuentes, Laura Morelli, Patricia Lillo, Paulo Caramelli, Renata Eloah de Lucena Ferretti-Rebustini, Stefanie Danielle Piña Escudero, Cecilia Serrano, Sonia Maria Dozzi Brucki, Heather M. Snyder, Sandra Baez, Ana Luisa Sosa, Alejandra Guerrero Barragan, Adelina Comas, Rosa Montesinos, Paulo Henrique Ferreira Bertolucci, Juan F. Cardona, Ioannis Tarnanas, Jerusa Smid, Lea T. Grinberg, Fernanda G. De Felice, Mario A. Parra, Christian Gonzalez-Billault, Cecilia Gonzalez Campo, Eliane Correa Miotto, David Huepe, Jose Manuel Santacruz-Escudero, Maria Aparecida Camargos Bicalho, Bruce L. Miller, P. Solis, Claudia K. Suemoto, Lissette Duque Peñailillo, Patricia J. Garcia, Marcia Lorena Fagundes Chaves, Lucas Porcello Schilling, Rodrigo B. Serafim, Claudia Ramos, Hernando Santamaría-García, Fabricio Joao Pio, Alyne Mendonca Marques Ton, Ignacio F. Mata, Irene Maier, Leonardo Cruz de Souza, Felipe A. Court, Lucas Sedeño, Myriam de la Cruz, Mônica Sanches Yassuda, Jenifer Yokoyama, Jorge J. Llibre Guerra, Fabricio Ferreira de Oliveira, Serggio Lanata, Nilton Custodio, Ricardo Nitrini, Andres Damian, Kenneth S. Kosik, Julián Bustin, Graciela Muniz-Terrera, Ceres Ferretti, Ivan Aprahamian, Diana Matallana, Olivier Piguet, Marcio Soto-Añari, Fiona Kumfor, Sergio T. Ferreira, Francisco Lopera, Mirna Lie Hosogi, and Luis Arnoldo Muñoz-Nevárez
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0301 basic medicine ,MEDICINA BASEADA EM EVIDÊNCIAS ,Latin Americans ,purl.org/pe-repo/ocde/ford#3.02.25 [https] ,NONPHARMACOLOGICAL INTERVENTIONS ,0302 clinical medicine ,purl.org/becyt/ford/3.2 [https] ,EPIDEMIOLOGY ,genetics ,NETWORKING AND TRANSLATIONAL RESEARCH ,media_common ,KNOWLEDGE TO ACTION FRAMEWORK ,Health Policy ,DEMENTIA ,Public relations ,networking and translational research ,Psychiatry and Mental health ,Action plan ,Evidence-Based Practice ,Perspective ,purl.org/becyt/ford/3 [https] ,epidemiology ,CLINICAL TRIALS ,evidence‐based recommendations ,GENETICS ,media_common.quotation_subject ,BIOMARKERS ,Translational research ,LATIN AMERICA ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,knowledge to action framework ,Political science ,nonpharmacological interventions ,medicine ,Dementia ,Humans ,EVIDENCE-BASED RECOMMENDATIONS ,Socioeconomic status ,clinical trials ,business.industry ,biomarkers ,Global strategy ,medicine.disease ,030104 developmental biology ,Transformative learning ,Latin America ,Socioeconomic Factors ,RC0321 ,Neurology (clinical) ,Geriatrics and Gerontology ,business ,030217 neurology & neurosurgery ,Diversity (politics) - Abstract
Across Latin American and Caribbean countries (LACs), the fight against dementia faces pressing challenges, such as heterogeneity, diversity, political instability, and socioeconomic disparities. These can be addressed more effectively in a collaborative setting that fosters open exchange of knowledge. In this work, the Latin American and Caribbean Consortium on Dementia (LAC-CD) proposes an agenda for integration to deliver a Knowledge to Action Framework (KtAF). First, we summarize evidence-based strategies (epidemiology, genetics, biomarkers, clinical trials, nonpharmacological interventions, networking, and translational research) and align them to current global strategies to translate regional knowledge into transformative actions. Then we characterize key sources of complexity (genetic isolates, admixture in populations, environmental factors, and barriers to effective interventions), map them to the above challenges, and provide the basic mosaics of knowledge toward a KtAF. Finally, we describe strategies supporting the knowledge creation stage that underpins the translational impact of KtAF. Fil: Parra, Mario Alfredo. Universidad Autónoma del Caribe; Colombia Fil: Baez, Sandra. Universidad de los Andes; Colombia Fil: Sedeño, Lucas. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Gonzalez Campo, Cecilia. Universidad de San Andrés; Argentina Fil: Santamaría García, Hernando. Pontificia Universidad Javeriana; Colombia Fil: Aprahamian, Ivan. No especifíca; Fil: Bertolucci, Paulo. Universidade Federal de Sao Paulo; Brasil Fil: Bustin, Julian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina Fil: Camargos Bicalho, Maria Aparecida. Universidade Federal de Minas Gerais; Brasil Fil: Cano Gutierrez, Carlos. Hospital Universitario San Ignacio; Colombia Fil: Caramelli, Paulo. Universidade Federal de Minas Gerais; Brasil Fil: Chaves, Marcia L. F.. Universidade Federal do Rio Grande do Sul; Brasil Fil: Perez Cogram, Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina Fil: Beber, Bárbara Costa. Universidade Federal do Rio Grande do Sul; Brasil Fil: Court, Felipe A.. Universidad Mayor; Chile Fil: de Souza, Leonardo Cruz. Universidade Federal de Minas Gerais; Brasil Fil: Custodio, Nilton. Peruvian Institute of Neurosciences; Perú Fil: Damian, Andres. Universidad de la República; Uruguay Fil: de la Cruz, Myriam. University of California; Estados Unidos Fil: Diehl Rodriguez, Roberta. Universidade de Sao Paulo; Brasil Fil: Dozzi Brucki, Sonia Maria. Universidade de Sao Paulo; Brasil Fil: Fajersztajn, Lais. Universidade de Sao Paulo; Brasil Fil: Farías, Gonzalo A.. Universidad de Chile; Chile Fil: De Felice, Fernanda G.. Universidade Federal do Rio de Janeiro; Brasil Fil: Ferrari, Raffaele. Colegio Universitario de Londres; Reino Unido Fil: Ferreira de Oliveira, Fabricio. Universidade de Sao Paulo; Brasil Fil: Ferreira, Sergio Teixeira. Universidade Federal do Rio de Janeiro; Brasil Fil: Ferretti, Ceres. Universidade de Sao Paulo; Brasil Fil: Figueredo Balthazar, Marcio Luiz. Universidade Estadual de Campinas; Brasil Fil: Ferreira Frota, Norberto Anizio. Universidade de Fortaleza; Brasil Fil: Fuentes, Patricio. No especifíca; Fil: García, Adolfo Martín. Universidad Nacional de Cuyo; Argentina. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Garcia, Patricia J.. Cayetano Heredia University; Perú Fil: de Gobbi Porto, Fábio Henrique. Universidade de Sao Paulo; Brasil Fil: Duque Peñailillo, Lissette. Ecuadorian Dementia Association; Ecuador Fil: Engler, Henry Willy. Universidad de la República; Uruguay Fil: Maier, Irene. Universidad de Chile; Chile Fil: Mata, Ignacio F.. University of Pittsburgh; Estados Unidos Fil: González Billault, Christian. Universidad de Chile; Chile Fil: Lopez, Oscar L.. University of Pittsburgh; Estados Unidos Fil: Morelli, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina Fil: Nitrini, Ricardo. Universidade de Sao Paulo; Brasil Fil: Quiroz, Yakeel T.. Harvard Medical School; Estados Unidos Fil: Guerrero Barragan, Alejandra. Universidad de la Sabana; Colombia Fil: Huepe, David. Universidad Adolfo Ibañez; Chile Fil: Pio, Fabricio Joao. Hospital Governador Celso Ramos; Brasil Fil: Suemoto, Claudia Kimie. Universidade de Sao Paulo; Brasil Fil: Kochhann, Renata. Pontificia Universidade Católica do Rio Grande do Sul; Brasil Fil: Kochen, Sara Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina Fil: Kumfor, Fiona. University of Western Sydney; Australia Fil: Lanata, Serggio. University of California; Estados Unidos Fil: Miller, Bruce. University of California; Estados Unidos Fil: Lessa Mansur, Leticia. Universidade de Sao Paulo; Brasil Fil: Lie Hosogi, Mirna. Universidade de Sao Paulo; Brasil Fil: Lillo, Patricia. Universidad de Chile; Chile Fil: Llibre Guerra, Jorge. University of California; Estados Unidos Fil: Lira, David. Peruvian Institute of Neurosciences; Perú Fil: Lopera, Francisco. Universidad de Antioquia; Colombia Fil: Comas, Adelina. No especifíca; Fil: Avila Funes, José Alberto. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán; México Fil: Sosa, Ana Luisa. Instituto Nacional de Neurología y Neurocirugía; México Fil: Ramos, Claudia. University of California; Estados Unidos Fil: de Paula França Resende, Elisa. University of California; Estados Unidos Fil: Snyder, Heather M.. No especifíca; Fil: Tarnanas, Ioannis. University of California; Estados Unidos Fil: Yokoyama, Jenifer. University of California; Estados Unidos Fil: Llibre, Juan. Centro de Estudios de Alzheimer; Cuba Fil: Cardona Londoño, Juan Felipe. Universidad del Valle; Colombia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Possin, Kate. University of California; Estados Unidos Fil: Kosik, Kenneth. University of California; Estados Unidos Fil: Montesinos, Rosa. Peruvian Institute of Neurosciences; Perú Fil: Moguilner, Sebastian Gabriel. University of California; Estados Unidos Fil: Solis, Patricia Cristina Lourdes. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic; Argentina. Universidad Nacional Arturo Jauretche; Argentina. Universidad de Buenos Aires; Argentina Fil: de Lucena Ferretti Rebustini, Renata Eloah. Universidade de Sao Paulo; Brasil Fil: Ramirez, Jeronimo Martin. No especifíca; Fil: Matallana, Diana. Pontificia Universidad Javeriana; Colombia Fil: Mbakile Mahlanza, Lingani. University of California; Estados Unidos Fil: Mendonça Marques Ton, Alyne. Universidade Federal do Rio de Janeiro; Brasil Fil: Melo Tavares, Ronnielly. Centro Universitario de Belo Horizonte.; Brasil Fil: Miotto, Eliane C.. Universidade de Sao Paulo; Brasil Fil: Muniz-Terrera, Graciela. University of Edinburgh; Reino Unido Fil: MuñozN evárez, Luis Arnoldo. University of California; Estados Unidos Fil: Orozco, David. Universidad Nacional del Sur; Argentina Fil: Okada de Oliveira, Maira. University of California; Estados Unidos Fil: Piguet, Olivier. University of Western Sydney; Australia Fil: Pintado Caipa, Maritza. University of California; Estados Unidos Fil: Piña Escudero, Stefanie Danielle. University of California; Estados Unidos Fil: Porcello Schilling, Lucas. Pontificia Universidade Católica do Rio Grande do Sul; Brasil Fil: Rodrigues Palmeira, André Luiz. Hospital Ernesto Dornelles; Brasil Fil: Sanches Yassuda, Mônica. Universidade de Sao Paulo; Brasil Fil: Santacruz Escudero, Jose Manuel. Pontificia Universidad Javeriana; Colombia Fil: Serafim, Rodrigo Bernardo. Universidade Federal do Rio de Janeiro; Brasil Fil: Smid, Jerusa. Universidade de Sao Paulo; Brasil Fil: Slachevsky, Andrea. Universidad de Chile; Chile Fil: Serrano, Cecilia Mariela. No especifíca; Fil: Soto Añari, Marcio. Universidad Católica San Pablo; Perú Fil: Takada, Leonel Tadao. Universidade de Sao Paulo; Brasil Fil: Tenenholz Grinberg, Lea. Universidade de Sao Paulo; Brasil Fil: Teixeira, Antonio Lucio. Universidade Federal de Minas Gerais; Brasil Fil: Tonidandel Barbosa, Maira. Universidade Federal de Minas Gerais; Brasil Fil: Trépel, Dominic. Trinity College; Estados Unidos Fil: Ibañez, Agustin Mariano. Universidad Autónoma del Caribe; Colombia. Universidad Adolfo Ibañez; Chile. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
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- 2020
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6. Genetic origin of a large family with a novel PSEN1 mutation (Ile416Thr)
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Lucia Madrigal, Margarita Giraldo, Ana Baena, Kenneth S. Kosik, J. Nicholas Cochran, Yakeel T. Quiroz, G. Garcia, Amanda Saldarriaga, Richard M. Myers, Daniel Camilo Aguirre-Acevedo, Ethan G. Geier, David Aguillon, Juliana Acosta-Uribe, Laura Ramirez Aguilar, Francisco Lopera, Jennifer S. Yokoyama, Rosario Cuastumal, Alexander Navarro, Sonia Moreno, and Diana Alzate
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Male ,0301 basic medicine ,Aging ,Epidemiology ,Neurodegenerative ,Alzheimer's Disease ,Genetic analysis ,Admixture in Latin America ,0302 clinical medicine ,PSEN1 ,2.1 Biological and endogenous factors ,Missense mutation ,Aetiology ,Age of Onset ,Autosomal dominant Alzheimer's disease ,Genetics ,education.field_of_study ,Presenilin 1 ,Health Policy ,Founder effect ,Genetic Bottleneck ,Middle Aged ,Psychiatry and Mental health ,Phenotype ,Neurological ,Mutation (genetic algorithm) ,Female ,Adult ,Clinical Sciences ,Population ,Mutation, Missense ,Colombia ,Biology ,Article ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Genetic drift ,Alzheimer Disease ,Acquired Cognitive Impairment ,Presenilin-1 ,Humans ,education ,Whole Genome Sequencing ,Human Genome ,Haplotype ,Neurosciences ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Brain Disorders ,030104 developmental biology ,Phenotype genotype correlation ,Geriatrics ,Mutation ,Dementia ,Neurology (clinical) ,Missense ,Geriatrics and Gerontology ,030217 neurology & neurosurgery - Abstract
Introduction A small percentage of Alzheimer's disease (AD) cases are caused by genetic mutations with autosomal dominant inheritance. We report a family with a novel variant in PSEN1. Methods We performed clinical and genetic evaluation of 93 related individuals from a Colombian admixed population. 31 individuals had whole-genome sequencing. Results Genetic analysis revealed a missense variant in PSEN1 (NM_000021.3: c.1247T>C p.Ile416Thr), which originated on an African haplotype and segregated with AD logarithm of the odds score of 6. Their clinical phenotype is similar to sporadic AD except for earlier age at onset: the mean age at onset for mild cognitive impairment was 47.6 years (standard deviation 5.83) and for dementia 51.6 years (standard deviation 5.03). Discussion Ile416Thr is a novel pathogenic variant that causes AD in the sixth decade of life. The history of the region that included slave importation and admixtures within a confined geographic locale represents a "mini-population bottleneck" and subsequent emergence of a rare dominant mutation.
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- 2019
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7. [P4–565]: CAREGIVING, EMPATHY, AND ALZHEIMER's DISEASE
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Kenneth S. Kosik and Bianca P. Aceved
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Psychotherapist ,Epidemiology ,Health Policy ,media_common.quotation_subject ,Empathy ,Disease ,Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Neurology (clinical) ,Geriatrics and Gerontology ,Psychology ,Clinical psychology ,media_common - Published
- 2017
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8. P2-126: LOSS-OF-FUNCTION CODING AND NON-CODING VARIANTS IN TET2 ARE ASSOCIATED WITH NEURODEGENERATIVE DISEASES
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Kenneth S. Kosik, Richard M. Myers, Michelle L. Thompson, Luke W. Bonham, Brittany N. Lasseigne, Francisco Lopera, James M.J. Lawlor, Anna Karydas, Bruce L. Miller, Ethan G. Geier, Jennifer S. Yokoyama, Erik D. Roberson, J. Scott Newberry, Gil D. Rabinovici, Gregory M. Cooper, Michelle D. Amaral, Meagan Cochran, Juliana Acosta-Uribe, and J. Nicholas Cochran
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Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Epidemiology ,Health Policy ,Philosophy ,Neurology (clinical) ,Geriatrics and Gerontology ,Theology - Abstract
Author(s): Cochran, J Nicholas; Geier, Ethan G; Acosta-Uribe, Juliana; Thompson, Michelle L; Amaral, Michelle D; Newberry, J Scott; Lawlor, James MJ; Lasseigne, Brittany N; Cochran, Meagan E; Bonham, Luke W; Karydas, Anna M; Roberson, Erik D; Lopera, Francisco; Kosik, Kenneth S; Cooper, Gregory M; Rabinovici, Gil D; Miller, Bruce L; Myers, Richard M; Yokoyama, Jennifer S
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- 2019
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9. O1‐04‐06: Elevated cerebrospinal fluid amyloid‐Beta42 levels in young adults at genetic risk for early‐onset alzheimer's disease
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Anne M. Fagan, Jessica B. Langbaum, Pierre N. Tariot, Kenneth S. Kosik, Yakeel T. Quiroz, Natalia Acosta-Baena, Margarita Giraldo, Marelene Jimenez del Rio, Kewei Chen, Francisco Lopera, Aarti R. Shah, Carlos Velez-Pardo, Adam S. Fleisher, and Eric M. Reiman
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Amyloid ,Epidemiology ,business.industry ,Health Policy ,medicine.disease ,Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Cerebrospinal fluid ,Developmental Neuroscience ,Immunology ,Medicine ,Early-onset Alzheimer's disease ,Neurology (clinical) ,Geriatrics and Gerontology ,Genetic risk ,Young adult ,business - Published
- 2011
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10. S4–03–05: Signal transduction
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Kenneth S. Kosik
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Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Epidemiology ,Health Policy ,Neurology (clinical) ,Geriatrics and Gerontology - Published
- 2006
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