1. Asian Cohort for Alzheimer's Disease (ACAD) pilot study on genetic and non‐genetic risk factors for Alzheimer's disease among Asian Americans and Canadians
- Author
-
Ho, Pei‐Chuan, Yu, Wai Haung, Tee, Boon Lead, Lee, Wan‐Ping, Li, Clara, Gu, Yian, Yokoyama, Jennifer S, Reyes‐Dumeyer, Dolly, Choi, Yun‐Beom, Yang, Hyun‐Sik, Vardarajan, Badri N, Tzuang, Marian, Lieu, Kevin, Lu, Anna, Faber, Kelley M, Potter, Zoë D, Revta, Carolyn, Kirsch, Maureen, McCallum, Jake, Mei, Diana, Booth, Briana, Cantwell, Laura B, Chen, Fangcong, Chou, Sephera, Clark, Dewi, Deng, Michelle, Hong, Ting Hei, Hwang, Ling‐Jen, Jiang, Lilly, Joo, Yoonmee, Kang, Younhee, Kim, Ellen S, Kim, Hoowon, Kim, Kyungmin, Kuzma, Amanda B, Lam, Eleanor, Lanata, Serggio C, Lee, Kunho, Li, Donghe, Li, Mingyao, Li, Xiang, Liu, Chia‐Lun, Liu, Collin, Liu, Linghsi, Lupo, Jody‐Lynn, Nguyen, Khai, Pfleuger, Shannon E, Qian, James, Qian, Winnie, Ramirez, Veronica, Russ, Kristen A, Seo, Eun Hyun, Song, Yeunjoo E, Tartaglia, Maria Carmela, Tian, Lu, Torres, Mina, Vo, Namkhue, Wong, Ellen C, Xie, Yuan, Yau, Eugene B, Yi, Isabelle, Yu, Victoria, Zeng, Xiaoyi, St George‐Hyslop, Peter, Au, Rhoda, Schellenberg, Gerard D, Dage, Jeffrey L, Varma, Rohit, Hsiung, Ging‐Yuek R, Rosen, Howard, Henderson, Victor W, Foroud, Tatiana, Kukull, Walter A, Peavy, Guerry M, Lee, Haeok, Feldman, Howard H, Mayeux, Richard, Chui, Helena, Jun, Gyungah R, Park, Van M Ta, Chow, Tiffany W, and Wang, Li‐San
- Subjects
Biomedical and Clinical Sciences ,Biological Psychology ,Clinical Sciences ,Neurosciences ,Psychology ,Clinical Trials and Supportive Activities ,Clinical Research ,Acquired Cognitive Impairment ,Minority Health ,Brain Disorders ,Dementia ,Alzheimer's Disease ,Aging ,Neurodegenerative ,Prevention ,Genetics ,Health Disparities ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,2.4 Surveillance and distribution ,Neurological ,Humans ,Alzheimer Disease ,Pilot Projects ,Asian ,Canada ,Risk Factors ,North American People ,Alzheimer's disease ,biosamples ,community-based participatory research ,dementia ,environmental ,genetics ,Geriatrics ,Clinical sciences ,Biological psychology - Abstract
IntroductionClinical research in Alzheimer's disease (AD) lacks cohort diversity despite being a global health crisis. The Asian Cohort for Alzheimer's Disease (ACAD) was formed to address underrepresentation of Asians in research, and limited understanding of how genetics and non-genetic/lifestyle factors impact this multi-ethnic population.MethodsThe ACAD started fully recruiting in October 2021 with one central coordination site, eight recruitment sites, and two analysis sites. We developed a comprehensive study protocol for outreach and recruitment, an extensive data collection packet, and a centralized data management system, in English, Chinese, Korean, and Vietnamese.ResultsACAD has recruited 606 participants with an additional 900 expressing interest in enrollment since program inception.DiscussionACAD's traction indicates the feasibility of recruiting Asians for clinical research to enhance understanding of AD risk factors. ACAD will recruit > 5000 participants to identify genetic and non-genetic/lifestyle AD risk factors, establish blood biomarker levels for AD diagnosis, and facilitate clinical trial readiness.HighlightsThe Asian Cohort for Alzheimer's Disease (ACAD) promotes awareness of under-investment in clinical research for Asians. We are recruiting Asian Americans and Canadians for novel insights into Alzheimer's disease. We describe culturally appropriate recruitment strategies and data collection protocol. ACAD addresses challenges of recruitment from heterogeneous Asian subcommunities. We aim to implement a successful recruitment program that enrolls across three Asian subcommunities.
- Published
- 2024