The challenges posed by climate change, biodiversity loss, and land-use are deeply interconnected and integrated solutions are needed. This paper presents results from 11 contributions to a special issue covering topics of integrated modeling and spatial prioritization, mass-balance studies, Earth Observation techniques, research infrastructure developments, and evaluation of policy measures and economic compensation schemes. The spatial scale of the studies ranges from detailed site-specific to a European scale. This paper briefly summarizes the main findings of these studies, makes some general overall conclusions, and identifies topics for further research and methods developments. [ABSTRACT FROM AUTHOR]