1. APOE Genotype in the Diagnosis of Alzheimer’s Disease in Patients With Cognitive Impairment
- Author
-
Aljoeson Walker, Xiaoyan Sun, Mark T. Wagner, Joyce S. Nicholas, and David Bachman
- Subjects
Male ,Apolipoprotein E ,medicine.medical_specialty ,Pathology ,Genotype ,Apolipoprotein E4 ,Disease ,Sensitivity and Specificity ,Apolipoproteins E ,Gene Frequency ,Alzheimer Disease ,Predictive Value of Tests ,Internal medicine ,medicine ,Humans ,Dementia ,Genetic Predisposition to Disease ,Age of Onset ,Family history ,Allele frequency ,Aged ,Retrospective Studies ,General Neuroscience ,Middle Aged ,medicine.disease ,Psychiatry and Mental health ,Clinical Psychology ,Predictive value of tests ,Female ,Geriatrics and Gerontology ,Alzheimer's disease ,Age of onset ,Cognition Disorders ,Psychology - Abstract
Background: Although an association between the apolipoprotein E ( APOE) ∊4 allele and increased risk of Alzheimer’s disease (AD) is established, the utility of APOE genotyping in the clinical diagnosis of AD is still under investigation. Methods: Medical records of 89 patients with cognitive impairment and APOE genotype data underwent a retrospective review. Results: Comparison of age, age at onset, education, Mini-Mental State Examination, months of follow-up, and family history of dementia did not reveal statistical difference among the patients with different APOE genotypes. The APOE ∊4 carriers had a higher percentage of AD diagnoses after a median 16 months follow-up than non- APOE ∊4 carriers. The APOE ∊4 designation had a high sensitivity and high positive predictive value for the diagnosis of AD but a low negative predictive value and specificity. Conclusions: The APOE genotyping may be helpful in diagnosing AD especially in patients presenting with atypical features or early age of onset of dementia.
- Published
- 2012