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Your search keyword '"Raij, Leopoldo"' showing total 3 results
Start Over Author "Raij, Leopoldo" Search Limiters Peer Reviewed Journal american journal of cardiology
3 results on '"Raij, Leopoldo"'

1. Lack of contribution of nitric oxide to basal vasomotor tone in heart failure

Author

Kubo, Spencer H., Rector, Thomas S., Bank, Alan J., Raij, Leopoldo, Kraemer, Mark D., Tadros, Peter, Beardslee, Michael, and Garr, Michael D.

Subjects
Congestive heart failure -- Physiological aspects, Nitric oxide -- Physiological aspects, Blood vessels -- Dilatation, Health
Abstract

Patients with heart failure have reduced forearm vasodilator responses when endothelial cell nitric oxide production is stimulated by muscarinic agonists. The aim of this study was to determine if activity of the nitric oxide pathway was also abnormal under basal conditions. Forearm blood flow (FBF) was measured with strain-gauge plethysmography in response to the intraarterial infusion of a subsystemic dose range of L-N-monomethylarginine (L-NMMA), a competitive inhibitor of nitric oxide synthase. In 18 normal subjects, the baseline FBF of 3.6 [+ or -] 1.4 was decreased by 0.3 [+ or -] 0.5 (p >0.01), 1.0 [+ or -] 0.7 (p (Am J Cardiol 1994; 74:1133--1136)

Published
1994

2. Effects of cardiac transplantation on endothelium-dependent dilation of the peripheral vasculature in congestive heart failure

Author

Kubo, Spencer H., Rector, Thomas S., Bank, Alan J., Tschumperlin, Linda K., Raij, Leopoldo, Brunsvold, Nancy, and Kraemer, Mark D.

Subjects
Heart -- Transplantation, Congestive heart failure -- Complications, Endothelium-derived relaxing factors -- Physiological aspects, Health
Abstract

Patients with congestive heart failure demonstrate attenuated endothelium-dependent vasodilation of the peripheral vasculature, but there are no data regarding the effect of therapies on this abnormality or whether this abnormality is reversible. This study was performed to address the hypothesis that abnormalities in endothelium-dependent vasodilation in heart failure are improved by heart transplantation. Forearm blood flow responses to the intraarterial administration of a dose range of methacholine, an endothelium-dependent vasodilator, and nitroprusside, an endothelium-independent vasodilator, were examined in 2 separate protocols. In protocol 1, forearm blood flow responses to methacholine in 14 heart transplant recipients were 5.02 [+ or -] 3.11, 11.55 [+ or -] 7.20 and 11.61 * 10.24 ml/min/100 ml forearm volume. These responses were sigaificantly greater then those in 10 patients with heart failure (2.23 [+ or -] 1.22, 4.60 [+ or -] 3.43 and 6.70 [+ or -] 4.91 ml/min/100 ml forearm volume; p (Am J Cardiol 1993;71:88-93)

Published
1993

3. Major and Minor Electrocardiographic Abnormalities and Their Association With Underlying Cardiovascular Disease and Risk Factors in Hispanics/Latinos (from the Hispanic Community Health Study/Study of Latinos).

Author

Denes, Pablo, Garside, Daniel B., Lloyd-Jones, Donald, Gouskova, Natalia, Soliman, Elsayed Z., Ostfeld, Robert, Zhu-Ming Zhang, Camacho, Alvaro, Prineas, Ronald, Raij, Leopoldo, and Daviglus, Martha L.

Subjects
*ELECTROCARDIOGRAPHY, *CARDIOVASCULAR diseases risk factors, *HEALTH of Hispanic Americans, *PUERTO Ricans, *LONGITUDINAL method, *COHORT analysis, *COMPARATIVE studies
Abstract

The association of electrocardiographic (ECG) abnormalities with cardiovascular disease and risk factors has been extensively studied in whites and African-Americans. Comparable data have not been reported in Hispanics/Latinos. The Hispanic Community Health Study/ Study of Latinos (HCHS/SOL) is a multicenter, community-based, prospective cohort study of men and women of diverse backgrounds aged 18 to 74 years who self-identified as Hispanic/Latinos. Participants (n = 16,415) enrolled from March 2008 to June 2011. We describe the prevalence of minor and major ECG abnormalities and examined their cross-sectional associations with cardiovascular disease and risk factors. The Minnesota code criteria were used to define minor and major ECG abnormalities. Previous cardiovascular disease and risk factors were based on data obtained at baseline examination. Significant differences in prevalent ECG findings were found between men and women. Major ECG abnormalities were present in 9.2% (95% confidence interval 8.3 to 10.1) of men and 6.6% (95% confidence interval 5.8 to 7.3) of women (p <0.0001). The odds of having major ECG abnormalities significantly increased with age, presence of ≥3 cardiovascular risk factors, and prevalent cardiovascular disease, in both men and women. Significant differences in major ECG abnormalities were found among the varying groups; Puerto Ricans and Dominicans had more major abnormalities compared with Mexican men and women. In conclusion, in a large cohort of Hispanic/Latino men and women, prevalence of major abnormalities was low, yet strong associations of major ECG abnormalities with cardiovascular disease and risk factors were observed in both men and women. [ABSTRACT FROM AUTHOR]

Published
2013
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