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Your search keyword '"Troen, Aron M."' showing total 4 results
Start Over Author "Troen, Aron M." Journal american journal of clinical nutrition
4 results on '"Troen, Aron M."'

1. MATIA variants are associated with hypertension, stroke, and markers of DNA damage and are modulated by plasma vitamin B-6 and folate

Author

Lai, Chao-Qiang, Parnell, Laurence D., Troen, Aron M., Shen, Jian, Caouette, Heather, Warodomwichit, Daruneewan, Lee, Yu-Chi, Crott, Jimmy W., Qiu, Wei Qiao, Rosenberg, Irwin H., Tucker, Katherine L., and Ordovas, Jose M.

Subjects
Cardiovascular diseases -- Risk factors, Cardiovascular diseases -- Genetic aspects, Cardiovascular diseases -- Prevention, Cardiovascular diseases -- Research, DNA damage -- Physiological aspects, DNA damage -- Research, Genetic variation -- Research, Vitamin B6 -- Health aspects, Vitamin B6 -- Research, Food/cooking/nutrition, Health
Abstract

Background: The S-adenosylmethionine synthetase type 1 (MAT1A) gene encodes a key enzyme in one-carbon nutrient metabolism. Objective: This study aimed to determine the association of MATIA variants with homocysteine, DNA damage, and cardiovascular disease (CVD). Design: Eight variants of MATIA were examined for associations with hypertension, stroke, CVD, homocysteine, and DNA damage in 1006 participants of the Boston Puerto Rican Health Study. Two variants were replicated in 1147 participants of the Nutrition, Aging, and Memory in Elders Study. Results: Two variants and haplotypes were strongly associated with hypertension and stroke, independent of methylenetetrahydrofolate reductase (MTHFR) variants. Homozygotes of the MATIA d18777A (rs3851059) allele had a significantly greater likelihood of stroke (odds ratio: 4.30; 95% CI: 1.34, 12.19; P = 0.006), whereas 3UI510A (rs7087728) homozygotes had a lower likelihood of hypertension (odds ratio: 0.67; 95% CI: 0.48, 0.95; P = 0.022) and stroke (odds ratio: 0.35; 95% CI: 0.15, 0.82; P = 0.015). A similar trend of association was observed in a second elderly population. Furthermore, strong interactions between MAT1A genotypes and vitamin B-6 status were found. Carriers of the nonrisk allele 3UI510A had a lower 8-hydroxydeoxyguanosine concentration--a biomarker of oxidative DNA damage--when plasma vitamin B-6 was high, whereas homozygotes for the risk-allele 3U1510G had higher 8-hydroxydeoxyguanosine concentrations, regardless of vitamin B-6 status. Conclusions: MAT1A variants were strongly associated with hypertension and stroke. Improving folate and vitamin B-6 status might decrease the CVD risk of only a subset of the population, depending on genotype. These findings suggest that impairments in methylation activity, independent of homocysteine, have an effect on CVD risk. doi: 10.3945/ajcn.2009.28923.

Published
2010

2. Circulating folic acid in plasma: relation to folic acid fortification

Author

Kalmbach, Renee D., Choumenkovitch, Silvina F., Troen, Aron M., D'Agostino, Ralph, Jacques, Paul F., and Selhub, Jacob

Subjects
Blood plasma -- Health aspects, Blood plasma -- Research, Folic acid -- Physiological aspects, Folic acid -- Health aspects, Folic acid -- Research, Food/cooking/nutrition, Health
Abstract

Background: The implementation of folic acid fortification in the United States has resulted in unprecedented amounts of this synthetic form of folate in the American diet. Folic acid in circulation may be a useful measure of physiologic exposure to synthetic folic acid, and there is a potential for elevated concentrations after fortification and the possibility of adverse effects. Objective: We assessed the effect of folic acid fortification on circulating concentrations of folic acid and 5-methyltetrahydrofolate in the Framingham Offspring Cohort. Design: This is a cross-sectional study that used plasma samples from fasting subjects before and after fortification. Samples were measured for folate distribution with the use of an affinity-HPLC method with electrochemical detection. Results: Among nonsupplement users, the median concentration of folic acid in plasma increased from 0.25 to 0.50 nmol/L (P < 0.001) after fortification, and among supplement users the median increased from 0.54 to 0.68 nmol/L (P = 0.001). Among nonsupplement users, the prevalence of high circulating folic acid ([great than or equal to] 85th percentile) increased from 9.4% to 19.1% (P = 0.002) after fortification. Among supplement users, the prevalence of high circulating folic acid increased from 15.9% to 24.3% (P = 0.02). Folic acid intake and total plasma folate were positively and significantly related to high circulating folic acid after adjustment for potential confounding factors (P for trend < 0.001). Conclusions: Folic acid fortification has resulted in increased exposure to circulating folic acid. The biochemical and physiologic consequences of this are unknown, but these findings highlight the need to understand the effects of chronic exposure to circulating folic acid. Am J Clin Nutr 2008;88:763-8.

Published
2008

3. Dihydrofolate reductase 19-bp deletion polymorphism modifies the association of folate status with memory in a cross-sectional multiethnic study of adults.

Author

Philip, Dana, Buch, Assaf, Moorthy, Denish, Scott, Tammy M., Parnell, Laurence D., Chao-Qiang Lai, Ordovás, José M., Selhub, Jacob, Rosenberg, Irwin H., Tucker, Katherine L., and Troen, Aron M.

Subjects
ANALYSIS of variance, COGNITION, DIETARY supplements, FACTOR analysis, FOLIC acid, GENETIC polymorphisms, LONGITUDINAL method, NEUROPSYCHOLOGICAL tests, MEMORY, META-analysis, MULTIVARIATE analysis, NUTRITION, PROBABILITY theory, PSYCHOLOGICAL tests, REGRESSION analysis, RESEARCH funding, STATISTICAL hypothesis testing, STATISTICS, T-test (Statistics), EVIDENCE-based medicine, GENOMICS, PROFESSIONAL practice, DATA analysis, INDEPENDENT living, CROSS-sectional method, EXECUTIVE function, DATA analysis software, DESCRIPTIVE statistics, NUTRITIONAL status, GENOTYPES
Abstract

Background: Folate status has been positively associated with cognitive function in many studies; however, some studies have observed associations of poor cognitive outcomes with high folate. In search of an explanation, we hypothesized that the association of folate with cognition would be modified by the interaction of high-folate status with a common 19-bp deletion polymorphism in the dihydrofolate reductase (DHFR) gene. To our knowledge, the cognitive effects of this gene have not been studied previously. Objective: We examined the association between cognitive outcomes with the 19-bp deletion DHFR polymorphism, folate status, and their interaction with high or normal plasma folate. Design: This was a pooled cross-sectional study of the following 2 Boston-based cohorts of community living adults: the Boston Puerto Rican Health Study and the Nutrition, Aging, and Memory in Elders study. Individuals were genotyped for the DHFR 19-bp deletion genotype, and plasma folate status was determined. Cognitive outcomes included the Mini-Mental State Examination, Center for Epidemiologic Studies Depression Scale, and factor scores for the domains of memory, executive function, and attention from a set of cognitive tests. Results: The prevalence of the homozygous deletion (del/del) genotype was 23%. In a multivariable analysis, high folate status (>17.8 ng/mL) was associated with better memory scores than was normal-folate status (fourth-fifth quintiles compared with first-third quintiles: β ± SE = 20.22 ± 0.06, P < 0.01). Carriers of the DHFR del/del genotype had worse memory scores (β± SE = 20.246 0.10, P< 0.05) and worse executive scores (β = 20.19, P< 0.05) than did those with the del/ins and ins/ins genotypes. Finally, we observed an interaction such that carriers of the del/del genotype with high folate had significantly worse memory scores than those of both noncarriers with high-folate and del/del carriers with normal-folate (β-interaction = 0.26 ± 0.13, P < 0.05). Conclusions: This study identifies a putative gene-nutrient interaction that, if confirmed, would predict that a sizable minority carrying the del/del genotype might not benefit from high-folate status and could see a worsening of memory. An understanding of how genetic variation affects responses to high-folate exposure will help weigh risks and benefits of folate supplementation for individuals and public health. [ABSTRACT FROM AUTHOR]

Published
2015
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4. Dihydrofolate reductase 19-bp deletion polymorphism modifies the association of folate status with memory in a cross-sectional multi-ethnic study of adults.

Author

Philip D, Buch A, Moorthy D, Scott TM, Parnell LD, Lai CQ, Ordovás JM, Selhub J, Rosenberg IH, Tucker KL, and Troen AM

Subjects
Black or African American, Aged, Aged, 80 and over, Boston epidemiology, Cohort Studies, Cross-Sectional Studies, Female, Folic Acid poisoning, Folic Acid Deficiency enzymology, Folic Acid Deficiency physiopathology, Genetic Association Studies, Hispanic or Latino, Humans, Male, Memory Disorders epidemiology, Middle Aged, Nutrigenomics methods, Prevalence, Puerto Rico ethnology, Tetrahydrofolate Dehydrogenase metabolism, White People, Folic Acid Deficiency genetics, Gene Deletion, Memory Disorders etiology, Nutritional Status, Polymorphism, Genetic, Tetrahydrofolate Dehydrogenase genetics
Abstract

Background: Folate status has been positively associated with cognitive function in many studies; however, some studies have observed associations of poor cognitive outcomes with high folate. In search of an explanation, we hypothesized that the association of folate with cognition would be modified by the interaction of high-folate status with a common 19-bp deletion polymorphism in the dihydrofolate reductase (DHFR) gene. To our knowledge, the cognitive effects of this gene have not been studied previously., Objective: We examined the association between cognitive outcomes with the 19-bp deletion DHFR polymorphism, folate status, and their interaction with high or normal plasma folate., Design: This was a pooled cross-sectional study of the following 2 Boston-based cohorts of community living adults: the Boston Puerto Rican Health Study and the Nutrition, Aging, and Memory in Elders study. Individuals were genotyped for the DHFR 19-bp deletion genotype, and plasma folate status was determined. Cognitive outcomes included the Mini-Mental State Examination, Center for Epidemiologic Studies Depression Scale, and factor scores for the domains of memory, executive function, and attention from a set of cognitive tests., Results: The prevalence of the homozygous deletion (del/del) genotype was 23%. In a multivariable analysis, high folate status (>17.8 ng/mL) was associated with better memory scores than was normal-folate status (fourth-fifth quintiles compared with first-third quintiles: β ± SE = -0.22 ± 0.06, P < 0.01). Carriers of the DHFR del/del genotype had worse memory scores (β ± SE = -0.24 ± 0.10, P < 0.05) and worse executive scores (β = -0.19, P < 0.05) than did those with the del/ins and ins/ins genotypes. Finally, we observed an interaction such that carriers of the del/del genotype with high folate had significantly worse memory scores than those of both noncarriers with high-folate and del/del carriers with normal-folate (β-interaction = 0.26 ± 0.13, P < 0.05)., Conclusions: This study identifies a putative gene-nutrient interaction that, if confirmed, would predict that a sizable minority carrying the del/del genotype might not benefit from high-folate status and could see a worsening of memory. An understanding of how genetic variation affects responses to high-folate exposure will help weigh risks and benefits of folate supplementation for individuals and public health., (© 2015 American Society for Nutrition.)

Published
2015
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