1. Shape Is Not Associated With the Origin of Pericolonic Tumor Deposits
- Author
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Bruno Märkl, Jenny Müller, Katharina Wünsch, Robert A. Herrmann, Hans Arnholdt, and Hendrik Jähnig
- Subjects
Male ,medicine.medical_specialty ,Pathology ,Adverse outcomes ,Colorectal cancer ,Nerve sheath ,medicine ,Lymphatic vessel ,Humans ,Neoplasm Invasiveness ,Lymphocytes ,Aged ,Neoplasm Staging ,Aged, 80 and over ,business.industry ,Carcinoma ,Cancer ,Anatomical pathology ,General Medicine ,Middle Aged ,medicine.disease ,medicine.anatomical_structure ,Lymphatic system ,Female ,Colorectal Neoplasms ,business ,Rectal disease - Abstract
Pericolonic tumor deposits (PTDs) are associated with an adverse outcome in colorectal cancer. According to the International Union Against Cancer they are classified as N1 or V1/V2 depending on their shape. This recommendation, however, is not well supported by the literature. To elucidate the origin of PTDs, we performed a histomorphologic study of 69 PTDs, which were found in 7 of 21 colorectal specimens using the whole-mount step-section technique. Depending on the origin, the nodules were classified as venous invasions, lymphatic invasions, nerve sheath infiltrations, free PTDs, and continuous growth in 18 (26%), 3 (4%), 6 (9%), 34 (49%), and 8 (12%) of 69 PTDs, respectively. Polycyclic and oval-round shapes were identified in all categories. Continuous growth was found only within the inner third of the adhering fat, whereas the other morphologic features were found in all regions. The data of this study do not support PTD classification on the basis of their shape.
- Published
- 2010
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