1. Rete Testis Invasion Is Consistent With Pathologic Stage T1 in Germ Cell Tumors
- Author
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Nicola Pavan, Elizabeth E. Whittington, Joy Liu, Lian Zhang, Beth L Braunhut, Tegan Miller, Aniko Szabo, Samarpit Rai, Kenneth A. Iczkowski, Oleksandr N. Kryvenko, Merce Jorda, Kristýna Procházková, Ayesha Farooq, Farooq, A., Jorda, M., Whittington, E., Kryvenko, O. N., Braunhut, B. L., Pavan, N., Prochazkova, K., Zhang, L., Rai, S., Miller, T., Liu, J., Szabo, A., and Iczkowski, K. A.
- Subjects
Male ,endocrine system ,Pathology ,medicine.medical_specialty ,Nonseminomatous germ cell tumor ,Pathologic stage ,Spermatic cord ,03 medical and health sciences ,0302 clinical medicine ,Testicular Neoplasms ,Rete testis ,Neoplasms ,Testis ,medicine ,Humans ,Neoplasm Invasiveness ,Stage (cooking) ,Neoplasm Staging ,Epididymis ,Neoplasm Invasivene ,Rete Testis ,business.industry ,General Medicine ,Seminoma ,Neoplasms, Germ Cell and Embryonal ,medicine.disease ,Rete Testi ,Rete ,Lymphovascular ,medicine.anatomical_structure ,Testi ,030220 oncology & carcinogenesis ,Pagetoid ,Concomitant ,Germ Cell and Embryonal ,Epididymi ,Germ cell tumors ,business ,Human ,030215 immunology - Abstract
Objectives Rete testis invasion by germ cell tumors is frequently concomitant with lymphovascular or spermatic cord invasion (LVI/SCI); independent implications for staging are uncertain. Methods In total, 171 seminomas and 178 nonseminomatous germ cell tumors (NSGCTs; 46 had 1%-60% seminoma component) came from five institutions. Metastatic status at presentation, as a proxy for severity, was available for all; relapse data were unavailable for 152. Rete direct invasion (ReteD) and rete pagetoid spread (ReteP) were assessed. Results ReteP and ReteD were more frequent in seminoma than NSGCT. In seminoma, tumor size bifurcated at 3 cm or more or less than 3 cm predicted metastatic status. Tumors with ReteP or ReteD did not differ in size from those without invasions but were less than with LVI/SCI; metastatic status or relapse did not show differences. In NSGCT, ReteP/ReteD did not correlate with size, metastatic status, or relapse. Conclusions Findings support retaining American Joint Committee for Cancer pathologic T1 stage designation for rete testis invasion and pT1a/pT1b substaging of seminoma.
- Published
- 2018
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