1. Comparative Study of the Clinical Pathology, Immunophenotype, Epstein-Barr Virus Infection Status, and Gene Rearrangements in Adult and Child Patients With Hydroa Vacciniforme-Like Lymphoproliferative Disorder.
- Author
-
Wen PF, Zhang M, Wang TT, Liu HJ, Zhang WY, Liu WP, and Wang L
- Subjects
- Adolescent, Adult, Age Factors, Child, Epstein-Barr Virus Infections genetics, Epstein-Barr Virus Infections immunology, Epstein-Barr Virus Infections virology, Facial Dermatoses genetics, Facial Dermatoses immunology, Facial Dermatoses virology, Female, Genetic Markers, Genetic Predisposition to Disease, Humans, Hydroa Vacciniforme genetics, Hydroa Vacciniforme immunology, Hydroa Vacciniforme virology, Immunohistochemistry, Immunophenotyping methods, In Situ Hybridization, Fluorescence, Lymphoma genetics, Lymphoma immunology, Lymphoma virology, Male, Mast Cells immunology, Mast Cells pathology, Mast Cells virology, Middle Aged, Phenotype, Polymerase Chain Reaction, Retrospective Studies, Risk Factors, Young Adult, Epstein-Barr Virus Infections diagnosis, Facial Dermatoses diagnosis, Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor, Genes, T-Cell Receptor gamma, Herpesvirus 4, Human isolation & purification, Hydroa Vacciniforme diagnosis, Lymphoma diagnosis, Skin immunology, Skin pathology, Skin virology
- Abstract
Background: Hydroa vacciniforme-like lymphoproliferative disorder (HVLPD) is a rare Epstein-Barr virus (EBV)-associated lymphoma that mainly affects children., Objectives: To examine the similarities and differences in the clinical pathological features, EBV infection status, and gene rearrangements in adults and children patients with HVLPD., Methods: We compared the clinical manifestations, histopathology, immunophenotypical features, EBV infection status, and T-cell receptor gene rearrangements in the adult and children HVLPD groups., Results: Clinical manifestations differed between children and adults groups. The children were characterized by blisters and severe facial swelling, whereas the adults were characterized by mild facial swelling and papules. Mosquito bite was significantly related to morbidity in the children group. Histologically, the number of mast cells in the adult group was greater than in the children group (P < 0.05). There were no significant differences in EBV infection status or TCR-γ gene rearrangements between 2 groups., Conclusions: There were differences in clinical pathology and prognosis between the 2 groups. A higher mast cell count and T-cell phenotype might be associated with a poor prognosis.
- Published
- 2019
- Full Text
- View/download PDF