1. Down syndrome and 3,3',5'-triiodothyronine
- Author
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Jérôme Lejeune, Marie Odile Rethoré, Jean Pierre Devaux, Marie Christine de Blois, and M Peeters
- Subjects
medicine.medical_specialty ,Pediatrics ,Down syndrome ,Triiodothyronine ,Adolescent ,Triiodothyronine, Reverse ,business.industry ,Infant ,medicine.disease ,Endocrinology ,Internal medicine ,Free triiodothyronine ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Genetics clinic ,medicine ,Humans ,Prospective Studies ,Down Syndrome ,business ,Trisomy ,Prospective cohort study ,Child ,Prospective survey - Abstract
Sir .—Since publications cross geographic but only rarely linguistic boundaries, we wish to bring to your attention our recent publication on elevated thyrotropin (TSH) levels and Down syndrome (DS). 1 Our findings are in accordance with those observed by Sharav et al. 2 A prospective survey was carried out on 78 patients with DS (age range, 6 months to 16 years; mean, 9.08±6.99 years) followed up at our genetics clinic, Hopital des Enfants Malades, Paris, France. The TSH levels were significantly elevated ( t = 9.5; P 4 ) levels between both groups (trisomy 21, 20.55±3.81 pmol/L; controls, 21.12±3.19 pmol/L). Free triiodothyronine (T 3 ) levels, however, tended to be lower in the DS group (7.09±1.68 pmol/L) vs controls (7.92±1.39 pmol/L) ( t =2.4; P =.05). We observed a
- Published
- 1990