1. Coffee, Tea, and Fatal Oral/Pharyngeal Cancer in a Large Prospective US Cohort.
- Author
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Hildebrand, Janet S., Patel, Alpa V., Mccullough, Marjorie L., Gaudet, Mia M., Chen, Amy Y., Hayes, Richard B., and Gapstur, Susan M.
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CAFFEINE , *COFFEE , *CONFIDENCE intervals , *STATISTICAL correlation , *DOSE-response relationship in biochemistry , *DRINKING (Physiology) , *LONGITUDINAL method , *MOUTH tumors , *QUESTIONNAIRES , *RESEARCH funding , *TEA , *DEATH certificates , *SECONDARY analysis , *RELATIVE medical risk , *PROPORTIONAL hazards models , *DESCRIPTIVE statistics ,PHARYNX tumors - Abstract
Epidemiologic studies suggest that coffee intake is associated with reduced risk of oral/pharyngeal cancer. The authors examined associations of caffeinated coffee, decaffeinated coffee, and tea intake with fatal oral/pharyngeal cancer in the Cancer Prevention Study II, a prospective US cohort study begun in 1982 by the American Cancer Society. Among 968,432 men and women who were cancer free at enrollment, 868 deaths due to oral/pharyngeal cancer occurred during 26 years of follow-up. Cox proportional hazards regression was used to estimate multivariable-adjusted relative risk. Intake of >4 cups/day of caffeinated coffee was associated with a 49% lower risk of oral/pharyngeal cancer death relative to no/occasional coffee intake (relative risk = 0.51, 95% confidence interval: 0.40, 0.64) (1 cup/day = 237 ml). A dose-related decline in relative risk was observed with each single cup/day consumed (Ptrend < 0.001). The association was not modified by sex, smoking status, or alcohol use. An inverse association for >2 cups/day of decaffeinated coffee intake was suggested (relative risk = 0.61, 95% confidence interval: 0.37, 1.01). No association was found for tea drinking. In this large prospective study, caffeinated coffee intake was inversely associated with oral/pharyngeal cancer mortality. Research is needed to elucidate biologic mechanisms whereby coffee might help to protect against these often fatal cancers. [ABSTRACT FROM PUBLISHER]
- Published
- 2013
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