1. Welding and Lung Cancer in a Pooled Analysis of Case-Control Studies
- Author
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Hans Kromhout, Paul A. Demers, Dario Mirabelli, Kurt Straif, Roel Vermeulen, Andrea 't Mannetje, Irene Brüske, Neil Pearce, Lorenzo Richiardi, Thomas Behrens, Jolanta Lissowska, Neonila Szeszenia-Dabrowska, Beate Pesch, Karl-Heinz Jöckel, Dario Consonni, Maria Teresa Landi, Ignatius Tak-sun Yu, Eleonora Fabianova, Benjamin Kendzia, Jack Siemiatycki, H.-Erich Wichmann, Neil E. Caporaso, David Zaridze, Ann Olsson, Thomas Brüning, Wolfgang Ahrens, Isabelle Stücker, Florence Guida, Adonina Tardón, Hermann Pohlabeln, Dana Mates, Michael W. Marcus, Lap Ah Tse, Peter Rudnai, Franco Merletti, Per Gustavsson, Francesco Forastiere, Bas Bueno-de-Mesquita, Paolo Boffetta, Vladimir Janout, Joachim Schüz, Vladimir Bencko, John R. McLaughlin, Susan Peters, Lenka Foretova, Rainer Van Gelder, Kendzia, B., Behrens, T., Jöckel, K.-H., Siemiatycki, J., Kromhout, H., Vermeulen, R., Peters, S., Gelder, R.V., Olsson, A., Brüske, I., Wichmann, H.-E., Stücker, I., Guida, F., Tardón, A., Merletti, F., Mirabelli, D., Richiardi, L., Pohlabeln, H., Ahrens, W., Landi, M.T., Caporaso, N., Consonni, D., Zaridze, D., Szeszenia-Dabrowska, N., Lissowska, J., Gustavsson, P., Marcus, M., Fabianova, E., Mannetje, A., Pearce, N., Tse, L.A., Yu, I.T.-S., Rudnai, P., Bencko, V., Janout, V., Mates, D., Foretova, L., Forastiere, F., McLaughlin, J., Demers, P., Bueno-De-Mesquita, B., Boffetta, P., Schüz, J., Straif, K., Pesch, B., and Brüning, T.
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Male ,medicine.medical_specialty ,Lung Neoplasms ,Time Factors ,Epidemiology ,Medizin ,Air Pollutants, Occupational ,Welding ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,law ,Internal medicine ,Odds Ratio ,medicine ,Humans ,Risk factor ,Lung cancer ,welding ,Lung ,business.industry ,Smoking ,Case-control study ,occupational exposure ,Odds ratio ,respiratory system ,medicine.disease ,030210 environmental & occupational health ,Confidence interval ,Surgery ,Occupational Diseases ,lung cancer ,medicine.anatomical_structure ,Case-Control Studies ,030220 oncology & carcinogenesis ,Adenocarcinoma ,case-control studie ,business ,Systematic Reviews and Meta- and Pooled Analyses - Abstract
Several epidemiologic studies have indicated an increased risk of lung cancer among welders. We used the SYNERGY project database to assess welding as a risk factor for developing lung cancer. The database includes data on 15,483 male lung cancer cases and 18,388 male controls from 16 studies in Europe, Canada, China, and New Zealand conducted between 1985 and 2010. Odds ratios and 95% confidence intervals between regular or occasional welding and lung cancer were estimated, with adjustment for smoking, age, study center, and employment in other occupations associated with lung cancer risk. Overall, 568 cases and 427 controls had ever worked as welders and had an odds ratio of developing lung cancer of 1.44 (95% confidence interval: 1.25, 1.67) with the odds ratio increasing for longer duration of welding. In never and light smokers, the odds ratio was 1.96 (95% confidence interval: 1.37, 2.79). The odds ratios were somewhat higher for squamous and small cell lung cancers than for adenocarcinoma. Another 1,994 cases and 1,930 controls had ever worked in occupations with occasional welding. Work in any of these occupations was associated with some elevation of risk, though not as much as observed in regular welders. Our findings lend further support to the hypothesis that welding is associated with an increased risk of lung cancer. © The Author 2013.
- Published
- 2013
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