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Your search keyword '"Dreger, Peter"' showing total 7 results
Start Over Author "Dreger, Peter" Journal american journal of hematology
7 results on '"Dreger, Peter"'

1. Impact of comorbidities and body mass index on the outcomes of allogeneic hematopoietic cell transplantation in myelofibrosis: A study on behalf of the Chronic Malignancies Working Party of EBMT

Author

Polverelli, Nicola, primary, Bonneville, Edouard F., additional, de Wreede, Liesbeth C., additional, Koster, Linda, additional, Kröger, Nicolaus Martin, additional, Schroeder, Thomas, additional, Peffault de Latour, Régis, additional, Passweg, Jakob, additional, Sockel, Katja, additional, Broers, Annoek E. C., additional, Clark, Andrew, additional, Dreger, Peter, additional, Blaise, Didier, additional, Yakoub‐Agha, Ibrahim, additional, Petersen, Soeren Lykke, additional, Finke, Jürgen, additional, Chevallier, Patrice, additional, Helbig, Grzegorz, additional, Rabitsch, Werner, additional, Sammassimo, Simona, additional, Arcaini, Luca, additional, Russo, Domenico, additional, Drozd‐Sokolowska, Joanna, additional, Raj, Kavita, additional, Robin, Marie, additional, Battipaglia, Giorgia, additional, Czerw, Tomasz, additional, Hernández‐Boluda, Juan Carlos, additional, and McLornan, Donal P., additional

Published
2024
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2. Treosulfan compared with <scp>reduced‐intensity</scp> busulfan improves allogeneic hematopoietic cell transplantation outcomes of older acute myeloid leukemia and myelodysplastic syndrome patients: Final analysis of a prospective randomized trial

Author

Beelen, Dietrich, Stelljes, Matthias, Reményi, Péter, Wagner‐Drouet, Eva‐Maria, Dreger, Peter, Bethge, Wolfgang, Ciceri, Fabio, Stölzel, Friedrich, Junghanß, Christian, Labussiere‐Wallet, Hélène, Schaefer‐Eckart, Kerstin, Grigoleit, Goetz U., Scheid, Christof, Patriarca, Francesca, Rambaldi, Alessandro, Niederwieser, Dietger, Hilgendorf, Inken, Russo, Domenico, Socié, Gérard, Holler, Ernst, Glass, Bertram, Casper, Jochen, Wulf, Gerald, Basara, Nadezda, Bieniaszewska, Maria, Stuhler, Gernot, Verbeek, Mareike, La Rocca, Ursula, Finke, Jürgen, Benedetti, Fabio, Pichlmeier, Uwe, Klein, Anja, Baumgart, Joachim, Markiewicz, Miroslaw, and Rocca, Ursula La

Subjects
Leukemia, Myeloid, Acute, Transplantation Conditioning, Myelodysplastic Syndromes, Medizin, Hematopoietic Stem Cell Transplantation, Graft vs Host Disease, Humans, Prospective Studies, Hematology, Middle Aged, Busulfan, Vidarabine, Aged
Abstract

The phase III study was designed to compare event-free survival (EFS) after treosulfan-based conditioning with a widely applied reduced-intensity conditioning (RIC) busulfan regimen in older or comorbid patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) undergoing allogeneic hematopoietic cell transplantation (HCT). A previously reported confirmatory interim analysis of the randomized clinical study including 476 patients demonstrated statistically significant noninferiority for treosulfan with clinically meaningful improvement in EFS. Here, the final study results and pre-specified subgroup analyses of all 570 randomized patients with completed longer-term follow-up are presented. Patients presenting HCT-specific comorbidity index >2 or aged >= 50 years were randomly assigned (1:1) to intravenous (IV) fludarabine with either treosulfan (30 g/m(2) IV) or busulfan (6.4 mg/kg IV) after stratification by disease risk group, donor type, and participating institution. The primary endpoint was EFS with disease recurrence, graft failure, or death from any cause as events. EFS of patients (median age 60 years) was superior after treosulfan compared to RIC busulfan: 36-months-EFS rate 59.5% (95% CI, 52.2-66.1) vs. 49.7% (95% CI, 43.3-55.7) with a hazard ratio (HR) of 0.64 (95% CI, 0.49-0.84), p = 0.0006. Likewise, overall survival (OS) with treosulfan was superior compared to busulfan: 36-month-OS rate 66.8% vs. 56.3%; HR 0.64 (95% CI, 0.48-0.87), p = 0.0037. Post hoc analyses revealed that these differences were consistent with the confirmatory interim analysis, and thereby the treosulfan regimen appears particularly suitable for older AML and MDS patients.

Published
2022

3. High dose chemotherapy and autologous stem cell transplantation in nodular lymphocyte‐predominant Hodgkin lymphoma: A retrospective study by the European society for blood and marrow transplantation‐lymphoma working party

Author

Akhtar, Saad, Montoto, Silvia, Boumendil, Ariane, Finel, Herve, Masszi, Tamas, Jindra, Pavel, Nemet, Damir, Fuhrmann, Stephan, Beguin, Yves, Castagna, Luca, Ferrara, Felicetto, Capria, Saveria, Malladi, Ram, Moraleda, Jose Maria, Bloor, Adrian, Ghesquières, Hervé, Meissner, Julia, Sureda, Anna, and Dreger, Peter

Published
2018
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4. Treosulfan compared with reduced‐intensity busulfan improves allogeneic hematopoietic cell transplantation outcomes of older acute myeloid leukemia and myelodysplastic syndrome patients: Final analysis of a prospective randomized trial

Author

Beelen, Dietrich W., primary, Stelljes, Matthias, additional, Reményi, Péter, additional, Wagner‐Drouet, Eva‐Maria, additional, Dreger, Peter, additional, Bethge, Wolfgang, additional, Ciceri, Fabio, additional, Stölzel, Friedrich, additional, Junghanß, Christian, additional, Labussiere‐Wallet, Hélène, additional, Schaefer‐Eckart, Kerstin, additional, Grigoleit, Goetz U., additional, Scheid, Christof, additional, Patriarca, Francesca, additional, Rambaldi, Alessandro, additional, Niederwieser, Dietger, additional, Hilgendorf, Inken, additional, Russo, Domenico, additional, Socié, Gérard, additional, Holler, Ernst, additional, Glass, Bertram, additional, Casper, Jochen, additional, Wulf, Gerald, additional, Basara, Nadezda, additional, Bieniaszewska, Maria, additional, Stuhler, Gernot, additional, Verbeek, Mareike, additional, La Rocca, Ursula, additional, Finke, Jürgen, additional, Benedetti, Fabio, additional, Pichlmeier, Uwe, additional, Klein, Anja, additional, Baumgart, Joachim, additional, and Markiewicz, Miroslaw, additional

Published
2022
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5. Improved relapse-free survival after autologous stem cell transplantation does not translate into better quality of life in chronic lymphocytic leukemia: Lessons from the randomized European Society for Blood and Marrow Transplantation-Intergroup study

Author

de Wreede, Liesbeth C., Watson, Maggie, van Os, Marleen, Milligan, Donald, van Gelder, Michel, Michallet, Mauricette, Dreger, Peter, Dearden, Claire E., Homewood, Janis, Dupuis, Jehan, Leporrier, Michel, Karas, Michal, Corront, Bernadette, Baerlocher, Gabriela M., Herr, Wolfgang, Choquet, Sylvain, Niederwieser, Dietger W., Sutton, Laurent, Kröger, Nicolaus, de Witte, Theo M., and Schetelig, Johannes

Published
2014
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6. High dose chemotherapy and autologous stem cell transplantation in nodular lymphocyte‐predominant Hodgkin lymphoma: A retrospective study by the European society for blood and marrow transplantation‐lymphoma working party

Author

Akhtar, Saad, primary, Montoto, Silvia, additional, Boumendil, Ariane, additional, Finel, Herve, additional, Masszi, Tamas, additional, Jindra, Pavel, additional, Nemet, Damir, additional, Fuhrmann, Stephan, additional, Beguin, Yves, additional, Castagna, Luca, additional, Ferrara, Felicetto, additional, Capria, Saveria, additional, Malladi, Ram, additional, Moraleda, Jose Maria, additional, Bloor, Adrian, additional, Ghesquières, Hervé, additional, Meissner, Julia, additional, Sureda, Anna, additional, and Dreger, Peter, additional

Published
2017
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7. Improved relapse-free survival after autologous stem cell transplantation does not translate into better quality of life in chronic lymphocytic leukemia: Lessons from the randomized European Society for Blood and Marrow Transplantation-Intergroup study.

Author

Wreede, Liesbeth C., Watson, Maggie, Os, Marleen, Milligan, Donald, Gelder, Michel, Michallet, Mauricette, Dreger, Peter, Dearden, Claire E., Homewood, Janis, Dupuis, Jehan, Leporrier, Michel, Karas, Michal, Corront, Bernadette, Baerlocher, Gabriela M., Herr, Wolfgang, Choquet, Sylvain, Niederwieser, Dietger W., Sutton, Laurent, Kröger, Nicolaus, and Witte, Theo M.

Published
2014
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