1. Stability of fluorouracil in plastic containers used for continuous infusion at home.
- Author
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Quebbeman EJ, Hamid AA, Hoffman NE, and Ausman RK
- Subjects
- Bromouracil analysis, Chromatography, High Pressure Liquid, Drug Packaging, Drug Stability, Home Care Services, Hot Temperature, Infusions, Parenteral, Plastics, Spectrophotometry, Ultraviolet, Time Factors, Fluorouracil administration & dosage, Fluorouracil analysis
- Abstract
The stability of fluorouracil when prepared and stored in plastic containers used for continuous infusion in home therapy was studied. Fluorouracil was diluted with 5% dextrose injection. Samples were stored for 16 weeks at 5 degrees C and room temperature in polyvinyl chloride drug reservoirs and at 5 degrees C in elastomeric balloons used in a disposable drug pump. Periodically, samples were tested by a stability-indicating high-performance liquid chromatography (HPLC) assay. At 5 degrees C, there was no significant degradation. At room temperature, there was a progressive increase in fluorouracil concentration, presumably because of evaporation of water. A 10% change in the fluorouracil concentration over 55 days was predicted. Fluorouracil is stable in 5% dextrose injection for at least 16 weeks when stored at 5 degrees C in the two types of containers studied.
- Published
- 1984