1. Identification of IL18RAP/IL18R1 and IL12B as Leprosy Risk Genes Demonstrates Shared Pathogenesis between Inflammation and Infectious Diseases
- Author
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Liu, Hong, Irwanto, Astrid, Tian, Hongqing, Fu, Xi'an, Yu, Yongxiang, Yu, Gongqi, Low, Huiqi, Chu, Tongsheng, Li, Yi, Shi, Benqing, Chen, Mingfei, Sun, Yonghu, Yuan, Chunying, Lu, Nan, You, Jiabao, Bao, Fangfang, Li, Jinghui, Liu, Jian, Liu, Huaxu, and Liu, Dianchang
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HANSEN'S disease , *HUMAN genes , *INTERLEUKINS , *INFLAMMATION , *COMMUNICABLE diseases , *LOCUS (Genetics) , *DISEASE risk factors - Abstract
Of eight leprosy susceptibility loci identified by genome-wide association studies, five have been implicated in Crohn disease, suggesting a common genetic fingerprint between leprosy and inflammatory bowel disease (IBD). Here, we conducted a multiple-stage genetic association study of 133 IBD susceptibility loci in multiple leprosy samples (totaling 4,971 leprosy cases and 5,503 controls) from a Chinese population and discovered two associations at rs2058660 on 2q12.1 (p = 4.57 × 10−19; odds ratio [OR] = 1.30) and rs6871626 on 5q33.3 (p = 3.95 × 10−18; OR = 0.75), implicating IL18RAP/IL18R1 and IL12B as susceptibility genes for leprosy. Our study reveals the important role of IL12/IL18-mediated transcriptional regulation of IFN-γ production in leprosy, and together with previous findings, it demonstrates the shared genetic susceptibility between infectious and inflammatory diseases. [Copyright &y& Elsevier]
- Published
- 2012
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