1. A Differential Response to Antihypertensive Therapy in African Men and Women: Insights From the CREOLE Trial
- Author
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Dike B Ojji, Gabriel L Shedul, Mahmoud Sani, Okechukwu S Ogah, Anastase Dzudie, Felix Barasa, Charles Mondo, Prossie M Ingabire, Erika S W Jones, Brian Rayner, Damasceno Albertino, Elijah Ogola, Wynand Smythe, Nicky Hickman, Veronica Francis, Pandie Shahiemah, Grace Shedul, Akinyemi Aje, Karen Sliwa, and Simon Stewart
- Subjects
Male ,Black People ,Blood Pressure ,Drug Combinations ,Hydrochlorothiazide ,Treatment Outcome ,Double-Blind Method ,Hypertension ,Perindopril ,Internal Medicine ,Humans ,Drug Therapy, Combination ,Female ,Amlodipine ,Antihypertensive Agents - Abstract
Background We sought to address the paucity of data to support the evidence-based management of hypertension to achieve optimal blood pressure (BP) control on a sex-specific basis in Africa. Methods We undertook a post hoc analysis of the multicenter, randomized CREOLE (Comparison of Three Combination Therapies in Lowering Blood Pressure in Black Africans) Trial to test the hypothesis that there would be clinically important differences in office BP control between African men and women. We compared the BP levels of 397 and 238 hypertensive women (63%, 50.9 ± 10.5 years) and men (51.2 ± 11.3 years) from 10 sites across sub-Saharan Africa who completed baseline and 6-month profiling according to their randomly allocated antihypertensive treatment. Results Overall, 442/635 (69.6%) participants achieved an office BP target of Conclusions These data suggest clinically important differences in the therapeutic response to antihypertensive combination therapy among African women compared with African men.
- Published
- 2022
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