1. Prenatal diagnosis of tetraploidy: a case report.
- Author
-
Coe SJ, Kapur R, Luthardt F, Rabinovitch P, and Kramer D
- Subjects
- Abnormalities, Multiple diagnosis, Abnormalities, Multiple diagnostic imaging, Adult, Female, Fetal Diseases diagnosis, Fetal Diseases diagnostic imaging, Humans, Karyotyping, Male, Phenotype, Pregnancy, Prenatal Diagnosis, Ultrasonography, Prenatal, Abnormalities, Multiple genetics, Fetal Diseases genetics, Polyploidy
- Abstract
We report on the second trimester prenatal diagnosis of an apparently nonmosaic tetraploid fetus, 92,XXYY. Indications for cytogenetic studies of the fetus included abnormal ultrasound findings and abnormal maternal serum levels of alpha-fetoprotein (AFP)/estriol. Chromosome analysis of amniocytes documented tetraploidy, a finding confirmed by flow cytometry of several fetal tissues. Autopsy findings in the fetus are compared with those of other cases of tetraploidy. To our knowledge this is the first reported prenatal diagnosis of a tetraploid fetus. Additionally, it illustrates the value of flow cytometric analysis of products of conception in which polyploidy is suspected.
- Published
- 1993
- Full Text
- View/download PDF