1. Cyclopia and congenital cytomegalovirus infection
- Author
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Paul J. Byrne, Meredith M. Silver, Joseph M. Gilbert, Werner Cadera, A. Keith Tanswell, and James F. Reynolds
- Subjects
Cerebral Cortex ,Male ,Pregnancy ,Skull ,Congenital cytomegalovirus infection ,Infant, Newborn ,virus diseases ,Transplacental ,Brain ,Cyclopia ,Biology ,medicine.disease ,Eye abnormality ,Holoprosencephaly ,Face ,Immunology ,Cytomegalovirus Infections ,medicine ,Humans ,Abnormalities, Multiple ,Female ,Eye Abnormalities ,Pregnancy Complications, Infectious ,Genetics (clinical) - Abstract
We describe the first documented association of congenital cytomegalovirus (CMV) infection and cyclopia. A previous report has suggested that any infant with congenital ocular defects should be investigated for CMV infection [Frenkel et al, 1980]. Our case underlines this suggestion and questions a teratogenic role for CMV in cyclopiaholoprosencephaly. More documented cases may help clarify the relationship of transplacental CMV infection to the holoprosencephaly developmental field defect, including cyclopia.
- Published
- 1987