1. Polygenic transmission and complex neuro developmental network for attention deficit hyperactivity disorder: Genome-wide association study of both common and rare variants
- Author
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Yang, Li, Neale, Benjamin M., Liu, Lu, Lee, S. Hong, Wray, Naomi R., Ji, Ning, Li, Haimei, Qian, Qiujin, Wang, Dongliang, Li, Jun, Faraone, Stephen V., Wang, Yufeng, Doyle, Alysa, Reif, Andreas, Rothenberger, Aribert, Franke, Barbara, Sonuga-Barke, Edmund J.S., Steinhausen, Hans-Christoph, Buitelaar, Jan K, Kuntsi, Jonna, Biederman, Joseph, Lesch, Klaus Peter, Kent, Lindsey, Asherson, Philip, Oades, Robert D., Loo, Sandra K., Nelson, Stanley F., Smalley, Susan L., Banaschewski, Tobias, Vasquez, Alejandro Arias, Todorov, Alexandre, Charach, A., Miranda, Ana, Warnke, Andreas, Thapar, Anita, Cormand, B., Freitag, Christine, Mick, Eric, Mulas, Fernando, Middleton, Frank, Hakonarson, Hakon, Pálmason, Haukur, Schäfer, Helmut, Roeyers, Herbert, McGough, James J., Romanos, Jasmin, Crosbie, J., Meyer, Jobst, Ramos-Qiroga, J.A., Sergeant, Joseph A, Elia, Josephine, Langely, Kate, Nisenbaum, Laura, Romanos, Marcel, Daly, Mark, Ribases, M., Gill, Michael, O’Donovan, Michael, Owen, Michael, Casas, M., Bayes, M., Lambregts-Rommelse, Nanda, Williams, Nigel, Holmans, Peter, Anney, Richard J.L., Ebstein, Richard, Schachar, R., Medland, Sarah E., Ripke, Stephan, Walitza, Susanne, Nguyen, Thuy Trang, Renner, Tobias J., Hu, Xiaolan, Psychiatrie & Neuropsychologie, Farmacologie en Toxicologie, RS: MHeNs School for Mental Health and Neuroscience, Yang, Li, Neale, Benjamin M, Liu, Lu, Lee, S Hong, Wray, Naomi R, Ji, Ning, Li, Haimei, Qian, Qiujin, Wang, Dongliang, Li, Jun, Faraone, Stephen V, Wang, Yufeng, and Psychiatric GWAS Consortium: ADHD Subgroup
- Subjects
Male ,Adolescent ,DCN MP - Plasticity and memory ,Medizin ,SNP ,Single-nucleotide polymorphism ,Genome-wide association study ,DCN PAC - Perception action and control ,Biology ,Polymorphism, Single Nucleotide ,Article ,Genomic disorders and inherited multi-system disorders DCN MP - Plasticity and memory [IGMD 3] ,Correlation ,single nucleotide polymorphisms ,Cellular and Molecular Neuroscience ,Polymorphism (computer science) ,attention-deficit hyperactivity disorder ,mental disorders ,medicine ,ddc:61 ,Humans ,ADHD ,GWAS ,Attention deficit hyperactivity disorder ,Genetic Predisposition to Disease ,DCN PAC - Perception action and control NCEBP 9 - Mental health ,ddc:610 ,Medizinische Fakultät » Universitätsklinikum Essen » LVR-Klinikum Essen » Klinik für Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters ,Copy-number variation ,Child ,Genetics (clinical) ,Genetics & Heredity ,Psychiatry ,Genetics ,neurodevelopment ,pathway ,Case-control study ,Genomic disorders and inherited multi-system disorders [DCN PAC - Perception action and control IGMD 3] ,medicine.disease ,genetic architecture ,Genetic architecture ,Psychiatry and Mental health ,polygenic disorders ,Attention Deficit Disorder with Hyperactivity ,Case-Control Studies ,Female ,Genome-Wide Association Study - Abstract
Attention-deficit hyperactivity disorder (ADHD) is a complex polygenic disorder. This study aimed to discover common and rare DNA variants associated with ADHD in a large homogeneous Han Chinese ADHD case-control sample. The sample comprised 1,040 cases and 963 controls. All cases met DSM-IV ADHD diagnostic criteria. We used the Affymetrix6.0 array to assay both single nucleotide polymorphisms (SNPs) and copy number variants (CNVs). Genome-wide association analyses were performed using PLINK. SNP-heritability and SNP-genetic correlations with ADHD in Caucasians were estimated with genome-wide complex trait analysis (GCTA). Pathway analyses were performed using the Interval enRICHment Test (INRICH), the Disease Association Protein-Protein Link Evaluator (DAPPLE), and the Genomic Regions Enrichment of Annotations Tool (GREAT). We did not find genome-wide significance for single SNPs but did find an increased burden of large, rare CNVs in the ADHD sample (P=0.038). SNP-heritability was estimated to be 0.42 (standard error, 0.13, P=0.0017) and the SNP-genetic correlation with European Ancestry ADHD samples was 0.39 (SE 0.15, P=0.0072). The INRICH, DAPPLE, and GREAT analyses implicated several gene ontology cellular components, including neuron projections and synaptic components, which are consistent with a neurodevelopmental pathophysiology for ADHD. This study suggested the genetic architecture of ADHD comprises both common and rare variants. Some common causal variants are likely to be shared between Han Chinese and Caucasians. Complex neurodevelopmental networks may underlie ADHD's etiology. (c) 2013 Wiley Periodicals, Inc. Refereed/Peer-reviewed
- Published
- 2013
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