1. Infectious mononucleosis mimicking a B cell immunoblastic lymphoma associated with an abnormality in regulatory T cells.
- Author
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Otteman LA, Greipp PR, Ruiz-Argüelles GJ, Banks PM, Li CY, and Katzmann JA
- Subjects
- Aged, B-Lymphocytes pathology, Bone Marrow pathology, Diagnosis, Differential, Female, Humans, Infectious Mononucleosis pathology, Leukocyte Count, Liver pathology, Lymph Nodes pathology, Lymphoma, Non-Hodgkin pathology, Infectious Mononucleosis diagnosis, Lymphoma, Non-Hodgkin diagnosis, T-Lymphocytes pathology
- Abstract
An elderly woman is described with infectious mononucleosis in whom cervical node biopsy was interpreted as showing immunoblastic lymphoma. Concomitant reactive lymphocytosis, Epstein-Barr virus serologic results consistent with an acute infection, and demonstration of polyclonal B cell infiltration of other tissues argued against intervention. Defective in vitro T cell responses were demonstrated during the acute phase of Epstein-Barr virus infection. Infectious mononucleosis has rarely been reported as mimicking a non-Hodgkin's lymphoma. At 18 months, our patient's course has been typical for infectious mononucleosis with no evidence of disseminated malignancy.
- Published
- 1985
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