1. Endothelial microparticles and the antiangiogenic state in preeclampsia and the postpartum period
- Author
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Mala Mahendroo, Loren Petrozella, Brenda C. Timmons, Donald D. McIntire, James M. Alexander, and Scott W. Roberts
- Subjects
Placental growth factor ,CD31 ,Adult ,medicine.medical_specialty ,Receptors, Cell Surface ,Pregnancy Proteins ,Article ,Preeclampsia ,Pre-Eclampsia ,Antigens, CD ,Cell-Derived Microparticles ,Pregnancy ,Internal medicine ,medicine ,Humans ,Prospective Studies ,Receptor ,Prospective cohort study ,reproductive and urinary physiology ,Placenta Growth Factor ,Vascular Endothelial Growth Factor Receptor-1 ,business.industry ,Postpartum Period ,Case-control study ,Endoglin ,Obstetrics and Gynecology ,Endothelial Cells ,medicine.disease ,Flow Cytometry ,Platelet Endothelial Cell Adhesion Molecule-1 ,Endocrinology ,Case-Control Studies ,Female ,business ,Postpartum period - Abstract
Objective We sought to determine if endothelial microparticles (EMPs), markers of endothelial damage, are associated with soluble fms-like tyrosine kinase 1 (sFlt1), soluble endoglin, and placental growth factor (PlGF) in women with preeclampsia. Study Design A prospective cohort study was conducted on 20 preeclamptic women and 20 controls. EMPs by flow cytometry, sFlt1, soluble endoglin, and PlGF were measured at time of enrollment, 48-hours postpartum, and 1-week postpartum. Results Preeclamptic CD31 + /42 − , CD62E + , and CD105 + EMP levels were significantly elevated in preeclamptics vs controls at time of enrollment. The sFlt1:PlGF ratio was correlated with CD31 + /42 − and CD105 + EMPs (r = 0.69 and r=0.51, respectively) in preeclampsia. Levels of CD31 + /42 − EMPs remained elevated 1-week postpartum ( P = .026). Conclusion EMPs are elevated in preeclampsia. The correlation of EMPs and the sFlt1:PlGF ratio suggests that antiangiogenesis is related to apoptosis of the endothelia. Endothelial damage persists 1 week after delivery.
- Published
- 2012