1. Unique case of malignant transformation of a vestibular schwannoma after fractionated radiotherapy
- Author
-
Dominique Liguoro, Vincent Darrouzet, Valérie Franco-Vidal, Sandrine Eimer, Clotilde Perret, Aymeri Huchet, John Goudakos, Konstantinos Markou, and J.-P. Maire
- Subjects
Adult ,medicine.medical_specialty ,Fractionated radiotherapy ,medicine.medical_treatment ,Schwannoma ,Malignant transformation ,Risk Factors ,otorhinolaryngologic diseases ,medicine ,Humans ,Clinical Oncology ,Vestibular system ,business.industry ,Dose fractionation ,Secondary Malignancy ,Neuroma, Acoustic ,medicine.disease ,Combined Modality Therapy ,Magnetic Resonance Imaging ,Surgery ,Radiation therapy ,Cell Transformation, Neoplastic ,Otorhinolaryngology ,Female ,Neoplasm Recurrence, Local ,Tomography, X-Ray Computed ,business - Abstract
Objective Malignant transformation of vestibular schwannoma is considered a rare clinical entity. Radiotherapy, as a treatment option for vestibular schwannoma, is regarded as a potential risk factor for secondary malignancy. Recently, radiotherapy with dose fractionation has been proposed, intended to diminish the risk of radiation-induced neuropathy. Case Presentation The aim of the present study is to report the first case, to the best of our knowledge, of malignant transformation of a residual vestibular schwannoma 19 years after fractionated radiotherapy, describing its characteristics with regard to those previously reported in the literature. Conclusions The main purpose of the present work is to state that the knowledge of the iatrogenic potential pitfalls of any technique of radiotherapy in clinical oncology is becoming a necessity. Finally, our report demonstrates that the irradiated patients must be monitored for life because a secondary malignancy may appear after a very long delay.
- Published
- 2012
- Full Text
- View/download PDF