1. Hair Cortisol Concentrations in Opioid-Exposed versus Nonexposed Mother-Infant Dyads.
- Author
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Morrison TM, Schiff DM, Olson A, Hunter RG, Agarwal J, Work EC, Muftu S, Shrestha H, Boateng J, Werler MM, Carter G, Jones HE, and Wachman EM
- Subjects
- Humans, Female, Pregnancy, Prospective Studies, Adult, Pilot Projects, Infant, Newborn, Infant, Pregnancy Complications, Prenatal Exposure Delayed Effects, Case-Control Studies, Young Adult, Male, Analgesics, Opioid adverse effects, Hydrocortisone analysis, Hydrocortisone metabolism, Hair chemistry, Opioid-Related Disorders, Biomarkers analysis, Biomarkers metabolism, Stress, Psychological metabolism
- Abstract
Objective: To pilot measurement of hair cortisol concentration (HCC) in pregnant women with opioid use disorder and their infants over time and study the potential utility of hair cortisol as a biomarker of chronic stress in this population., Study Design: In this pilot prospective cohort study of mother-infant dyads with and without prenatal opioid exposure, we obtained mother-infant HCCs at delivery and again within 1 to 3 months' postpartum. HCCs were compared between the opioid and control groups and between the two time points., Results: There were no significant differences between opioid and control group maternal or infant HCCs at either time point. However, within the opioid-exposed group, there was a significant increase in infant HCCs across the two time points., Conclusion: This pilot study describes our experience with the measurement of HCCs in opioid-exposed mother-infant dyads., Key Points: · Maternal stress impacts fetal and child health.. · Many stressors in pregnant women with opioid use disorder.. · Hair cortisol may be a useful stress biomarker.., Competing Interests: None declared., (Thieme. All rights reserved.)
- Published
- 2024
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