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Objectives: A decline in functional status is common during acute care hospitalization and may make patients vulnerable to further complications. This decline can be mitigated through hospital-based early activity and mobility programs. An important component of successful activity and mobility programs is systematic documentation of patient function, which can be an important barrier to program implementation in the acute care setting. Herein, we present a new nursing-based documentation system created as part of an early activity and mobility quality improvement (QI) project. Design: This project was undertaken, using a structured QI process, on two 24-bed general medicine units in an academic hospital. Our performance measure was based on a mobility scale currently-used in the ICU setting, known as "highest level of mobility" (HLM). HLM served as a daily "vital sign" and is an ordinal scale ranging from 1 to 8 (example scores: 1 = bed rest, 6 = ambulating >10 steps, 8 = ambulating >250 feet). We present prospective data on 440 consecutive patients with a length of stay (LOS) >2 days, admitted between 3/1/2013 and 6/7/2013. We analyzed the association between the average HLM during the first 2 days of admission for each patient and our two primary outcomes, hospital LOS and discharge to home. After logarithmic transformation, LOS was analyzed using linear regression. Discharge to home was analyzed using logistic regression. These models were adjusted for 7 relevant variables (age, gender, race, marital status, payer, expected LOS, and the AHRQ comorbidity index). Results: Mean (T standard deviation) LOS was 6.9 (±5.1), with 385 (88%) patients discharged home. Compared to non-ambulatory patients (HLM <6), patients who were able to ambulate >10 steps or more (HLM ≥6) during their first two days on admission had significantly shorter mean hospital LOS (6.4 (±5.3) versus 7.4 (±4.9) days, p=0.03), and higher rates of discharge home (98% versus 77%, p<0.001). In our adjusted analysis, a 1 point increase in HML was associated with a significantly shorter LOS by 0.6 (95% CI 0.3-0.8, p<0.001) days and an increased odds of discharge to home (OR 1.8, 95% CI 1.5-2.2, p<0.001). Conclusions: When implemented within a structured QI project, nursing-based documentation of patients' physical function shortly after acute care hospital admission may be helpful in identifying general medicine patients requiring a longer length of stay and institutionalization at discharge. [ABSTRACT FROM AUTHOR]