Search

Your search keyword '"Zhongwei Xu"' showing total 2 results
Start Over Author "Zhongwei Xu" Journal american journal of physical medicine & rehabilitation
2 results on '"Zhongwei Xu"'

1. Efficacy of Platelet-Rich Plasma in Pain and Self-Report Function in Knee Osteoarthritis

Author

Xiao Huang, Jiao Luo, Zhongwei Xu, Jian Zhang, Aiguo Zhou, and Bin Wang

Subjects
Male, medicine.medical_specialty, Knee Joint, Treatment outcome, Physical Therapy, Sports Therapy and Rehabilitation, Osteoarthritis, Injections, Intra-Articular, law.invention, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Adjuvants, Immunologic, Double-Blind Method, Randomized controlled trial, law, Hyaluronic acid, Humans, Pain Management, Medicine, Hyaluronic Acid, Self report, Pain Measurement, Randomized Controlled Trials as Topic, 030203 arthritis & rheumatology, 030222 orthopedics, Platelet-Rich Plasma, business.industry, Rehabilitation, Middle Aged, Osteoarthritis, Knee, medicine.disease, Arthralgia, Treatment Outcome, chemistry, Platelet-rich plasma, Meta-analysis, Physical therapy, Female, Self Report, Best evidence, business
Abstract

The aim of this study was to assess the efficacy of platelet-rich plasma (PRP) in pain and self-report function of patients with knee osteoarthritis on the basis of comparisons with hyaluronic acid or placebo.Best-evidence synthesis of randomized controlled trials (RCTs) was conducted. Literature retrieval was limited to RCTs assessing the efficacy of PRP in knee osteoarthritis. Methodology evaluation and data extraction were based on Cochrane Collaboration guidelines. Meta-analyses were performed using mean difference or standardized mean difference as effect size.Ten RCTs were included and analyzed. Meta-analysis showed significant superiority of PRP in outcome scores when compared with hyaluronic acid (standardized mean difference = -0.85, P = 0.004, I = 93%), but no statistical difference was found in well-designed double-blind trials (standardized mean difference = -0.09, P = 0.38, I = 0%). Pooled standardized mean difference of trials comparing PRP with placebo directly was -2.13 (95% confidence interval = -3.29 to -0.98), and that of indirect comparison was -0.22 (95% confidence interval = -0.45 to -0.01).In relieving pain and improving self-report function, PRP showed no superiority over hyaluronic acid in well-designed double-blind trials, and beneficial effects of PRP in most trials probably resulted from insufficient blinding methods. However, PRP is still considered more effective than placebo on the basis of present evidence.

Published
2017

2. Efficacy of Platelet-Rich Plasma in Pain and Self-Report Function in Knee Osteoarthritis: A Best-Evidence Synthesis.

Author

Zhongwei Xu, Jiao Luo, Xiao Huang, Bin Wang, Jian Zhang, and Aiguo Zhou

Subjects
*OSTEOARTHRITIS treatment, *CONFIDENCE intervals, *HYALURONIC acid, *IMMUNOLOGICAL adjuvants, *MEDICAL databases, *INFORMATION storage & retrieval systems, *MEDICAL information storage & retrieval systems, *INTRA-articular injections, *KNEE, *KNEE diseases, *MEDLINE, *META-analysis, *OSTEOARTHRITIS, *PROBABILITY theory, *QUESTIONNAIRES, *SELF-evaluation, *PAIN management, *SYSTEMATIC reviews, *EVIDENCE-based medicine, *EFFECT sizes (Statistics), *PAIN measurement, *VISUAL analog scale, *TREATMENT effectiveness, *DATA analysis software, *FUNCTIONAL assessment, *JOINT pain, *PLATELET-rich plasma, *DISEASE complications, *THERAPEUTICS
Abstract

Objective: The aim of this study was to assess the efficacy of platelet-rich plasma (PRP) in pain and self-report function of patients with knee osteoarthritis on the basis of comparisons with hyaluronic acid or placebo. Design: Best-evidence synthesis of randomized controlled trials (RCTs) was conducted. Literature retrieval was limited to RCTs assessing the efficacy of PRP in knee osteoarthritis. Methodology evaluation and data extraction were based on Cochrane Collaboration guidelines. Meta-analyses were performed using mean difference or standardized mean difference as effect size. Results: Ten RCTs were included and analyzed. Meta-analysis showed significant superiority of PRP in outcome scores when compared with hyaluronic acid (standardized mean difference = -0.85, P= 0.004, I² = 93%), but no statistical difference was found in well-designed double-blind trials (standardized mean difference = -0.09, P= 0.38, I² = 0%). Pooled standardized mean difference of trials comparing PRP with placebo directly was -2.13 (95% confidence interval = -3.29 to -0.98), and that of indirect comparison was -0.22 (95% confidence interval = -0.45 to -0.01). Conclusions: In relieving pain and improving self-report function, PRP showed no superiority over hyaluronic acid in well-designed double-blind trials, and beneficial effects of PRP in most trials probably resulted from insufficient blinding methods. However, PRP is still considered more effective than placebo on the basis of present evidence. [ABSTRACT FROM AUTHOR]

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results