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Studies A[sub2A] adenosine receptor-mediated inhibition of renal injury and neutrophil adhesion. Reduction of neutrophil density in outer medulla of rats with A[sub2A] adenosine receptor activation; Influence of A[sub2A] adenosine receptors on renal tissue injury when administered to animals subjected to ischemia/reperfusion.

Investigates whether selective alpha2A adenosine receptor activation reduces ischemia-reperfusion injury in the rat kidney. Effect of adenosine on neutrophils and endothelial cells; Reduction in tubular injury and ischemic necrosis after ischemia-reperfusion injury following treatment with the adenosine analog DWH-146e.

Examines the influence of polarization of receptor expression on the activity of their effector molecule, adenylyl cyclase. What immunohistochemistry and Western blot analysis confirmed; Assessment of adenylyl cyclase activity; Concluding remarks.