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Studies A[sub2A] adenosine receptor-mediated inhibition of renal injury and neutrophil adhesion. Reduction of neutrophil density in outer medulla of rats with A[sub2A] adenosine receptor activation; Influence of A[sub2A] adenosine receptors on renal tissue injury when administered to animals subjected to ischemia/reperfusion.

Investigates whether selective alpha2A adenosine receptor activation reduces ischemia-reperfusion injury in the rat kidney. Effect of adenosine on neutrophils and endothelial cells; Reduction in tubular injury and ischemic necrosis after ischemia-reperfusion injury following treatment with the adenosine analog DWH-146e.

Investigates apical membrane and intracellular distribution of endogenous alpha2A-adrenergic receptors in Madin-Darby canine kidney (MDCK) cells. Analysis of saturation binding; Specific binding of [3H]MK-912 to soluble apical and basolateral surface proteins.

Examines the influence of polarization of receptor expression on the activity of their effector molecule, adenylyl cyclase. What immunohistochemistry and Western blot analysis confirmed; Assessment of adenylyl cyclase activity; Concluding remarks.