1. Activation of the CRF 2 receptor modulates skeletal muscle mass under physiological and pathological conditions
- Author
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Jana S. Lange, Richard T. Hinkle, Elizabeth Donnelly, Eric Tobar, Russell James Sheldon, Sarah C. Coste, Steven Samuelsson, Robert J. Isfort, Mark A. Tarnopolsky, Mary Beth Bauer, David B. Cody, and Mary P. Stenzel-Poore
- Subjects
Male ,medicine.medical_specialty ,Physiology ,Peptide Hormones ,Endocrinology, Diabetes and Metabolism ,Biology ,Receptors, Corticotropin-Releasing Hormone ,Amphibian Proteins ,Dexamethasone ,Muscle hypertrophy ,Rats, Sprague-Dawley ,Mice ,Atrophy ,Physiology (medical) ,Internal medicine ,medicine ,Animals ,Muscle, Skeletal ,Receptor ,Insulin-like growth factor 1 receptor ,Denervation ,Skeletal muscle ,Organ Size ,medicine.disease ,Sciatic Nerve ,Muscular Disorders, Atrophic ,Hindlimb ,Rats ,Mice, Inbred C57BL ,Muscular Atrophy ,medicine.anatomical_structure ,Endocrinology ,Female ,Stress, Mechanical ,medicine.symptom ,Peptides ,ITGA7 ,hormones, hormone substitutes, and hormone antagonists ,Muscle Contraction ,Muscle contraction - Abstract
Two receptors activated by the corticotropin-releasing factor (CRF) family of peptides have been identified, the CRF 1 receptor (CRF1R) and the CRF 2 receptor (CRF2R). Of these, the CRF2R is expressed in skeletal muscle. To understand the role of the CRF2R in skeletal muscle, we utilized CRFR knockout mice and CRF2R-selective agonists to modulate nerve damage and corticosteroid- and disuse-induced skeletal muscle atrophy in mice. These analyses demonstrated that activation of the CRF2R decreased nerve damage and corticosteroid- and disuse-induced skeletal muscle mass and function loss. In addition, selective activation of the CRF2R increased nonatrophy skeletal muscle mass. Thus we describe for the first time a novel activity of the CRF2R, modulation of skeletal muscle mass.
- Published
- 2003
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