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Start Over Author "Fumika Ochiai" Journal american journal of physiology-renal physiology
1 results on '"Fumika Ochiai"'

1. A novel I551F variant of the Na+/HCO3− cotransporter NBCe1-A shows reduced cell surface expression, resulting in diminished transport activity

Author

Shigeru Shibata, Taiji Furukawa, Maho Yamashita, Matsuhiko Hayashi, Junichi Hirahashi, Yoshihide Fujigaki, Jinping Li, Osamu Yamazaki, George Seki, Tadashi Yoshida, Fumika Ochiai-Homma, and Ken Kozuma

Subjects
Glycosylation, biology, Physiology, Transport activity, Cell, medicine.disease, Molecular biology, chemistry.chemical_compound, medicine.anatomical_structure, chemistry, Na hco3 cotransporter, medicine, biology.protein, Surface expression, Cotransporter, SLC4A4, Proximal renal tubular acidosis
Abstract

Electrogenic Na+/[Formula: see text] cotransporter 1-A (NBCe1-A) in the proximal tubule regulates the acid/base balance and fluid volume homeostasis. From the National Center for Biotechnology Information dbSNP database, we identified the I551F variant of NBCe1-A, which showed reduced glycosylation, cell surface expression, and transport activity. We also found that the I551F variant can exert a dominant negative effect on wild-type NBCe1-A, suggesting its physiological significance.

Published
2021

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