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Start Over Author "Joshua Carty" Journal american journal of physiology-renal physiology
1 results on '"Joshua Carty"'

1. Insulin-regulated aminopeptidase is required for water excretion in response to acute hypotonic stress

Author

Yvonne Zuchowski, Joshua Carty, Andrew S. Terker, Fabian Bock, Jonathan B. Trapani, Gautam Bhave, Jason A. Watts, Susanna Keller, Mingzhi Zhang, Roy Zent, Raymond C. Harris, and Juan Pablo Arroyo

Subjects
Physiology
Abstract

Insulin-regulated aminopeptidase (IRAP) degrades vasopressin, but its role in urinary concentration and dilution is unknown. Here, we show that IRAP-deficient mice have a high urinary osmolality at baseline and are unable to excrete free water in response to water loading. These results reveal a novel regulatory role for IRAP in urine concentration and dilution.

Published
2023

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