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Your search keyword '"Cognition disorders in old age -- Physiological aspects"' showing total 3 results
Start Over Descriptor "Cognition disorders in old age -- Physiological aspects" Journal american journal of psychiatry
3 results on '"Cognition disorders in old age -- Physiological aspects"'

1. Association between decline in brain dopamine activity with age and cognitive and motor impairment in healthy individuals

Author

Volkow, Nora D., Gur, Ruben C., Wang, Gene-Jack, Fowler, Joanna S., Moberg, Paul J., Ding, Yu-Shin, Hitzemann, Robert, Smith, Gwenn, and Logan, Jean

Subjects
Brain -- Physiological aspects, Dopamine -- Physiological aspects, Age -- Physiological aspects, Cognition disorders in old age -- Physiological aspects, Motor ability -- Physiological aspects, Health, Psychology and mental health
Published
1998

2. Combined analysis of CSF tau levels and [[sup.123]I]Iodoamphetamine SPECT in mild cognitive impairment: implications for a novel predictor of Alzheimer's disease. (Brief Report)

Author

Okamura, Nobuyuki, Arai, Hiroyuki, Maruyama, Masahiro, Higuchi, Makoto, Matsui, Toshifumi, Tanji, Haruko, Seki, Takashi, Hirai, Hisao, Chiba, Hiroshi, Itoh, Masatoshi, and Sasaki, Hidetada

Subjects
Cognition disorders in old age -- Physiological aspects, Alzheimer's disease -- Research, Cerebral circulation -- Testing, Cerebrospinal fluid -- Analysis, Health, Psychology and mental health
Abstract

Objective: The aim of this study was to establish an objective and reliable index to predict the development of Alzheimer's disease in a large pool of elderly patients with mild cognitive impairment. Method: Twenty-three patients with probable Alzheimer's disease, 22 patients with mild cognitive impairment who eventually developed Alzheimer's disease, eight patients with mild cognitive impairment who did not develop dementia, and 19 cognitively normal subjects were included in the study. The authors constructed a new diagnostic index, the CSF-CBF index, based on CSF tau levels divided by regional cerebral blood flow (CBF) in the posterior cingulate cortex. Results: Receiver operating characteristic analysis showed that applying a cutoff value for the CSF-CBF index of 296.0 achieved a sensitivity of 88.5% and a specificity of 90.0% in discriminating mild cognitive impairment that progressed to Alzheimer's disease from mild cognitive impairment that did not progress to Alzheimer's disease. Conclusions: The CSF-CBF index is useful in predicting Alzheimer's disease in subjects with mild cognitive impairment.

Published
2002

3. Age-Related Cognitive Deficits Mediated by Changes in the Striatal Dopamine System

Author

Backman, Lars, Ginovart, Nathalie, Dixon, Roger A., Wahlin, Tarja-Brita Robins, Wahlin, Ake, Halidin, Christer, and Farde, Lars

Subjects
Aging -- Physiological aspects, Cognition disorders in old age -- Physiological aspects, Dopaminergic mechanisms -- Psychological aspects, Health, Psychology and mental health
Abstract

Objective: The study examined the influence of losses in dopaminergic function on age-related cognitive deficits. Method: Eleven healthy subjects (21-68 years of age) completed a set of cognitive tasks used to assess perceptual speed and episodic memory. D(sub 2) receptor binding was measured in the caudate and the putamen by using positron emission tomography. Results: A gradual age-related deterioration was found for all cognitive tasks and for D(sub 2) binding in both striatal structures. Statistical control of D(sub 2) binding eliminated the age-related cognitive variation, whereas residual effects of D(sub 2) binding were seen after the analysis controlled for age. Conclusions: D(sub 2) receptor binding is a more important factor than chronological age in accounting for variation in cognitive performance across the adult life-span. Changes in dopaminergic neurotransmission play an important role in aging-related cognitive decline.

Published
2000

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