1. Persistent choreoathetosis in a fatal olanzapine overdose: drug kinetics, neuroimaging, and neuropathology.
- Author
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Davis, Larry E., Becher, Mark W., Thomak, Wieslawa, Benson, Blame E., Lee, Roland R., Fisher, Ellen C., Tlomak, Wieslawa, and Benson, Blaine E
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OLANZAPINE , *ANTIPSYCHOTIC agents , *TOXICOLOGICAL emergencies , *POISON control centers , *AFFECTIVE disorders , *NEUROLOGICAL disorders - Abstract
The article presents information on the consequences of overdoses of olanzapine. It reports that typical antipsychotics are a relatively new group of medications for the management of psychosis. Currently approved medications of this category include clozapine, risperidone, quetiapine, and olanzapine. Overdoses can lead to deaths. The American Association of Poison Control Centers Toxic Exposure Surveillance System reported the number of deaths associated with olanzapine to be six in 2000, 10 in 2001, and 10 in 2002. The article presents a case history of a 62-year-old married man who had a long and clear history of bipolar affective disorder with features of obsessive compulsion, and was treated by psychiatrists for more than 10 years.
- Published
- 2005
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